Synthesis and Characterization of Pullulan Acetate Coated Magnetic Nanoparticle for Hyperthermic Therapy

Saranya, D.; Rajan, R. Sundara; Suganthan, V.; Murugeswari, A.; Raj, N. Arunai Nambi

doi:10.1016/j.mspro.2015.06.017

Cited by 15 publications

(5 citation statements)

References 13 publications

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“…They are also environmentally friendly, sustainable and naturally renewable [ 13 ]. Previous studies have been successfully achieved by introducing various polymers such as biodegradable chitosan nanofibers [ 14 ], gelatin [ 15 ], amino-functionalized [ 5 ], dextran [ 16 , 17 ], pullulan [ 18 ] and starch [ 19 ]. Kloster et al reported of a magnetic composite film based on alginate as convenient and efficient natural polymer-based adsorbents [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Development of Nanocomposite Film Comprising of Polyvinyl Alcohol (PVA) Incorporated with Bacterial Cellulose Nanocrystals and Magnetite Nanoparticles

et al. 2021

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Nanocomposite film of poly(vinyl alcohol) (PVA) incorporated with bacterial cellulose nanocrystals (BCNCs) and magnetite nanoparticles (Fe3O4) is reported in this study. The BCNC-Fe3O4 nanoparticles and PVA film was prepared by in situ synthesis technique using chemical co-precipitation. Different concentrations of BCNC-Fe3O4 (20%, 40% and 60% w/w) were mechanically dispersed in PVA solution to form the nanocomposite film. Transmission electron microscopy (TEM) analysis of BCNC-Fe3O4 nanoparticles showed irregular particle sizes ranging from 4.93 to 30.44 nm with an average size distribution of 22.94 nm. The presence of characteristic functional groups of PVA, BCNC and Fe3O4 were confirmed by Fourier transform infrared (FTIR) spectroscopy and X-ray diffraction (XRD) analysis. Scanning electron microscope (SEM) attached energy dispersive spectroscopy (EDS) and vibrating sample magnetometer (VSM) analysis revealed that, the iron content and magnetic property increased with increasing BCNC-Fe3O4 content. The saturation magnetizations (MS) value increased from 5.14 to 11.56 emu/g. The PVA/ BCNC-Fe3O4 at 60% showed the highest Young’s modulus value of 2.35 ± 0.16 GPa. The prepared film could be a promising polymeric nanomaterial for various magnetic-based applications and for the design of smart electronic devices.

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Section: Introductionmentioning

confidence: 99%

Development of Nanocomposite Film Comprising of Polyvinyl Alcohol (PVA) Incorporated with Bacterial Cellulose Nanocrystals and Magnetite Nanoparticles

et al. 2021

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“…Great therapeutic efficacy has been demonstrated on KB cells, in which temperatures of 45 • C and 47 • C resulted in proliferation reduction of 56% and 78%, respectively. 85 Baker et al 86 demonstrated biocompatible nanocomposite iron oxide/phospholipid core/shell oxide particles in the magnetic hyperthermia therapy. This combination of nanoparticles placed in various environments, such as air and aqueous solution, presents great stability and biocompatibility of the surface.…”

Section: Hyperthermiamentioning

confidence: 99%

Superparamagnetic iron oxide nanoparticles (SPIONs) as a multifunctional tool in various cancer therapies

Musielak

Piotrowski

Suchorska

2019

Reports of Practical Oncology & Radiotherapy

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Over the past two decades nanotechnology has become an important part of novel medical research. Researchers have made great progress in developing nanotechnology applications used for detecting and treating oncological diseases. Recently, many research groups have focused on the use of superparamagnetic iron oxide nanoparticles (SPIONs) in cancer treatment. Due to the range of therapeutic properties and possibilities of various modifications, SPIONs are a promising and multifunctional tool in various cancer therapies and may help to overcome the limitations of conventional therapies. Moreover, it is still necessary to develop new methods of treatment with expected properties, such as lower toxicity, long-lasting effectiveness and higher selectivity. Analyzing the literature data, we found that currently SPIONs are used in the transport of drugs, immunotherapy and hyperthermia. The main aim of this review is to present various cancer treatment therapies utilizing SPIONs, the importance of the experiments carried out by research groups and further perspectives in the nanotechnological use of SPIONs.

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“…Magnetic nanoparticles (MNPs) are attracting much scientific attention due to their application in the fields of theranostic imaging, cell tracking, MRI, hyperthermia, drug delivery, giant magnetoresistance-based biosensors, and the separation of biomolecules such as DNA and proteins [ 1 , 2 , 3 , 4 ]. Uniquely, MNPs possess inverse spinel structures in the form of MFe 2 O 4 , where M corresponds to Co +2 , Fe +2 , Ni +2 , Mn +2 , etc., and inhabits either tetrahedral or octahedral interstitial sites.…”

Section: Introductionmentioning

confidence: 99%

“…Cobalt ferrites have a slower magnetic moment relaxation when compared to magnetite. Moreover, when such ferrites are altered by different biocompatible surface modifiers such as pullulan [ 3 ], chitosan [ 4 , 31 , 32 , 33 ], polyethylene glycol [ 2 , 4 , 34 , 35 , 36 ], dextran [ 36 ], etc., then their biocompatibility is further enhanced.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and Magnetic Hyperthermia of Monodispersed Cobalt Ferrite Nanoparticles for Cancer Therapeutics

et al. 2020

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Magnetic nanoparticles such as cobalt ferrite are investigated under clinical hyperthermia conditions for the treatment of cancer. Cobalt ferrite nanoparticles (CFNPs) synthesized by the thermal decomposition method, using nonionic surfactant Triton-X100, possess hydrophilic polyethylene oxide chains acting as reducing agents for the cobalt and iron precursors. The monodispersed nanoparticles were of 10 nm size, as confirmed by high-resolution transmission electron microscopy (HR-TEM). The X-ray diffraction patterns of CFNPs prove the existence of cubic spinel cobalt ferrites. Cs-corrected scanning transmission electron microscopy–high-angle annular dark-field imaging (STEM–HAADF) of CFNPs confirmed their multi-twinned crystallinity due to the presence of atomic columns and defects in the nanostructure. Magnetic measurements proved that the CFNPs possess reduced remnant magnetization (MR/MS) (0.86), which justifies cubic anisotropy in the system. Microwave-based hyperthermia studies performed at 2.45 GHz under clinical conditions in physiological saline increased the temperature of the CFNP samples due to the transformation of radiation energy to heat. The specific absorption rate of CFNPs in physiological saline was 68.28 W/g. Furthermore, when triple-negative breast cancer cells (TNBC) in the presence of increasing CFNP concentration (5 mg/mL to 40 mg/mL) were exposed to microwaves, the cell cytotoxicity was enhanced compared to CFNPs alone.

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Synthesis and Characterization of Pullulan Acetate Coated Magnetic Nanoparticle for Hyperthermic Therapy

Cited by 15 publications

References 13 publications

Development of Nanocomposite Film Comprising of Polyvinyl Alcohol (PVA) Incorporated with Bacterial Cellulose Nanocrystals and Magnetite Nanoparticles

Development of Nanocomposite Film Comprising of Polyvinyl Alcohol (PVA) Incorporated with Bacterial Cellulose Nanocrystals and Magnetite Nanoparticles

Superparamagnetic iron oxide nanoparticles (SPIONs) as a multifunctional tool in various cancer therapies

Synthesis, Characterization and Magnetic Hyperthermia of Monodispersed Cobalt Ferrite Nanoparticles for Cancer Therapeutics

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