Synthesis and characterization of polyhedral oligomeric silsesquioxane hybrid co‐crosslinked poly(N‐isopropylacrylamide‐co‐dimethylaminoethyl methacrylate) hydrogels

Abstract

Polyhedral oligomeric silsesquioxane hybrid temperature and pH double‐responsive hydrogels with organic–inorganic co‐crosslinked networks are synthesized by in situ, free‐radical polymerization of N‐isopropylacrylamide and dimethylaminoethyl methacrylate in the presence of both organic crosslinker N,N′‐methylenebis(acrylamide) (BIS) and inorganic crosslinker octavinyl polyhedral oligomeric silsesquioxane (OvPOSS) in tetrahydrofuran media. The resulting hydrogels (OR‐OvP gels) display obvious temperature and pH double responsiveness, OvPOSS particles dispersed in polymer make a dominant effect on the properties of gels. With the increase of OvPOSS, the aggregation of particles on nano‐ or microscale happens and causes a considerable change on the properties of gels, such as the lower critical solution temperature and better compression strength. Specially, the interconnected microporous structure of gels ascribed to the microphase separation results in faster deswelling rate, which makes the gel become attractive. Besides, the crosslink by BIS intensifies the heterogeneity of gels significantly, which could also be used to adjust the properties of gels. © 2013 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2013, 51, 1494–1504

Synthesis of polyhedral oligomeric silsesquioxane nano‐crosslinked poly(ethylene glycol)‐based hybrid hydrogels for drug delivery and antibacterial activity

“…(a)) crosslinked with glycerol shows a uniform microstructure with collapsed pores. The images for G1 and G2 with different OA‐POSS contents (Figs (b) and (c)) clearly show an increase in porosity with increasing POSS content from 1.5 to 3 wt%, which can be attributed to microphase separation and the formation of hydrophobic nanodomains around OA‐POSS . The formation of hydrophobic nanodomains around OA‐POSS can also affect the equilibrium water uptake of the hybrid hydrogels.…”

Donut-like hybrid latex comprising discrete thermoplastic lobe and thermosetting shell

“…In spite of this, a previous study proposed the copolymerization of OVPOSS with styrene in the presence of substantial amount of the latter [20]. Most often, the free-radical polymerization of OVPOSS and a vinyl monomer in a homogeneous system results in composites, such as methyl [21][22], acetoxystyrene [23], vinylpyrrolidone [24], N-isopropylacrylamide and N,N-dimethylaminoethyl methacrylate [25] and etc. In contrast, OVPOSS has seldom been used to prepare latex particles, except that Wang et al [26] has reported a synthesis of an OVPOSS-PS latex composite with a POSS enriched core.…”

Multi-stimuli-responsive semi-IPN cryogels with native and anionic potato starch entrapped in poly(N,N-dimethylaminoethyl methacrylate) matrix and their potential in drug delivery

“…Due to the reversible swelling/shrinkage capacity, these materials have been explored in the last decade for various technological and biomedical applications, such as sensors, separations, drug delivery systems, cartilage, artificial muscles, and actuators. The interest in finding novel biocompatible polymers, which could respond to two or more external stimuli, is growing and therefore various types of such polymers have been prepared in the last decade [7][8][9][10][11][12]. As reported in literature, poly(N,N-dimethylaminoethyl methacrylate) (PDMAEM) is a polycation endowed with antibacterial, hemostatic and anticancer properties [13,14], which has been used in the preparation of new drug or gene delivery systems [15].…”