Synthesis and characterization of poly (l-lactide/ε-caprolactone) statistical copolymers with well resolved chain microstructures

Fernández, Jorge Sobral; Meaurio, Emilio; Chaos, Ana; Etxeberria, Agustín; Alonso‐Varona, Ana; Sarasua, Jose‐Ramon

doi:10.1016/j.polymer.2013.03.009

Cited by 62 publications

(50 citation statements)

References 37 publications

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“…The PLCL consisted of a statistical polymer containing 50 wt% of l ‐lactide, 35 wt% of d, l ‐lactide (>99.5%, Purac Biochem BV, Gorinchem, The Netherlands) and 15 wt% of ϵ‐caprolactone (>98%, Merck KGaA, Damstadt, Germany) while PLLA was a classical linear chain of l ‐lactide conformers. Both polymers were synthetized through ring‐opening polymerization process, as described elsewhere . The reaction was catalyzed by bismuth (III) subsalicylate (BiSS, 99.9% trace metals basis, Sigma–Aldrich, 1500: 1 comonomers: catalyst molar ratio) during 24 h at 130 °C.…”

Section: Methodsmentioning

confidence: 99%

Design, Degradation Mechanism and Long‐Term Cytotoxicity of Poly(l‐lactide) and Poly(Lactide‐co‐ϵ‐Caprolactone) Terpolymer Film and Air‐Spun Nanofiber Scaffold

Sabbatier

Larrañaga

Guay‐Bégin

et al. 2015

Macromolecular Bioscience

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Degradable nanofiber scaffold is known to provide a suitable, versatile and temporary structure for tissue regeneration. However, synthetic nanofiber scaffold must be properly designed to display appropriate tissue response during the degradation process. In this context, this publication focuses on the design of a finely-tuned poly(lactide-co-ϵ-caprolactone) terpolymer (PLCL) that may be appropriate for vascular biomaterials applications and its comparison with well-known semi-crystalline poly(l-lactide) (PLLA). The degradation mechanism of polymer film and nanofiber scaffold and endothelial cells behavior cultured with degradation products is elucidated. The results highlights benefits of using PLCL terpolymer as vascular biomaterial compared to PLLA.

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Section: Methodsmentioning

confidence: 99%

Design, Degradation Mechanism and Long‐Term Cytotoxicity of Poly(l‐lactide) and Poly(Lactide‐co‐ϵ‐Caprolactone) Terpolymer Film and Air‐Spun Nanofiber Scaffold

Sabbatier

Larrañaga

Guay‐Bégin

et al. 2015

Macromolecular Bioscience

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“…The number-average sequence lengths of L-LA (L LA ) and e-CL (L CL ) and the degree of randomness in the multiarmed star-shaped poly(L-lactide-co-e-caprolactone) copolymers were determined by 1 H-NMR and 13 C-NMR with a method reported in the literature. [24][25][26][27] All of the copolymers were found to be truly random (Table III, entries 1-6). The absolute molecular weights of the multiarmed star random copolymers of L-LA and e-CL were determined with a GPC multidetector.…”

Section: Synthesis Of the Multiarmed Star Poly(l-lactide-co-ecaprolacmentioning

confidence: 98%

Synthesis and characterization of well‐defined random and block copolymers of ε‐caprolactone with l‐lactide as an additive for toughening polylactide: Influence of the molecular architecture

Deokar

Idage

et al. 2015

J of Applied Polymer Sci

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Well-defined multiarmed star random and block copolymers of e-caprolactone with L-lactide with controlled molecular weights, low polydispersities, and precise numbers of arms were synthesized by the ring-opening polymerization of respective cyclic ester monomers. The polymers were characterized by 1 H-NMR and 13 C-NMR to determine their chemical composition, molecular structure, degree of randomness, and proof of block copolymer formation. Gel permeation chromatography was used to establish the degree of branching. Star-branched random copolymers exhibited lower glass-transition temperatures (T g 's) compared to a linear random copolymer. When the star random copolymers were melt-blended with poly(L-lactic acid) (PLA), we observed that the elongation of the blend increased with the number of arms of the copolymer. Six-armed block copolymers, which exhibited higher T g 's, caused the maximum improvement in elongation. In all cases, improvements in the elongation were achieved with no loss of stiffness in the PLA blends.

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“…The copolymerization of e-caprolactone with L-lactide [25,26] or d-valerolactone [27][28][29][30] units was the strategy used by our research group to reduce crystallinity and so improve the biodegradability of the PCL homopolymer [31]. For this purpose, several e-caprolactone-co-L-lactide and e-caprolactone-co-d-valerolactone copolymers were synthesized in a previous study of ours [32] using triphenyl bismuth (Ph 3 Bi), a catalyst that is known to favor random sequences [33].…”

Section: Introductionmentioning

confidence: 99%

In vitro degradation studies and mechanical behavior of poly(ε-caprolactone-co-δ-valerolactone) and poly(ε-caprolactone-co-L-lactide) with random and semi-alternating chain microstructures

Fernández

Etxeberria

Sarasua

2015

European Polymer Journal

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Synthesis and characterization of poly (l-lactide/ε-caprolactone) statistical copolymers with well resolved chain microstructures

Cited by 62 publications

References 37 publications

Design, Degradation Mechanism and Long‐Term Cytotoxicity of Poly(l‐lactide) and Poly(Lactide‐co‐ϵ‐Caprolactone) Terpolymer Film and Air‐Spun Nanofiber Scaffold

Design, Degradation Mechanism and Long‐Term Cytotoxicity of Poly(l‐lactide) and Poly(Lactide‐co‐ϵ‐Caprolactone) Terpolymer Film and Air‐Spun Nanofiber Scaffold

Synthesis and characterization of well‐defined random and block copolymers of ε‐caprolactone with l‐lactide as an additive for toughening polylactide: Influence of the molecular architecture

In vitro degradation studies and mechanical behavior of poly(ε-caprolactone-co-δ-valerolactone) and poly(ε-caprolactone-co-L-lactide) with random and semi-alternating chain microstructures

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