Synthesis and characterization of pH-sensitivity semi-IPN hydrogel based on hydrogen bond between poly(N-vinylpyrrolidone) and poly(acrylic acid)

Jin, Shengye; Liu, Mingzhu; Zhang, Fen; Chen, Shilan; Niu, Aizhen

doi:10.1016/j.polymer.2006.01.009

Cited by 141 publications

(77 citation statements)

References 23 publications

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“…The main peaks of AA are -OH stretch at 3380 cm -1 , -CH stretch at 2922 cm -1 and -C=O stretch at 1718.5 cm -1 (Ranjha et al, 2011). PVP shows peaks at 2924 cm -1 for CH stretching, a stretching peak between 1650 to 1659 cm -1 for carbonyl stretching (C=O) and 1290 cm -1 for amide band III (C-N stretch) (Jin et al, 2006). In the FTIR spectrum ( Figure 2), carbonyl bands in complex were broader than in pure PVP and AA, and are evidence of intermolecular hydrogen bonding.…”

Section: Fourier Transform Infrared (Ftir) Spectroscopymentioning

confidence: 97%

pH-sensitive polyvinylpyrrolidone-acrylic acid hydrogels: Impact of material parameters on swelling and drug release

Sohail

Khan

Shahzad

et al. 2014

Braz. J. Pharm. Sci.

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In this study, we fabricated pH-sensitive polyvinylpyrrolidone/acrylic acid (PVP/AA) hydrogels by a free-radical polymerisation method with variation in the content of monomer, polymer and cross-linking agent. Swelling was performed in USP phosphate buffer solutions of pH 1.2, 5.5, 6.5 and 7.5 with constant ionic strength. Network structure was evaluated by different parameters and FTIR confirmed the formation of cross-linked hydrogels. X-ray crystallography showed molecular dispersion of tramadol HCl. A drug release study was carried out in phosphate buffer solutions of pH 1.2, 5.5 and 7.5 for selected samples. It was observed that swelling and drug release from hydrogels can be modified by changing composition and degree of cross-linking of the hydrogels under investigation. Swelling coefficient was high at higher pH values except for the one containing high PVP content. Drug release increased by increasing the pH of the medium and AA contents in hydrogels while increasing the concentration of cross-linking agent had the opposite effect. Analysis of the drug release mechanism revealed non-Fickian transport of tramadol from the hydrogels.Uniterms: Drugs/release. Hydrogels/pH sensitive. Polyvinylpyrrolidone-acrilic acid/hidrogels. Tramadol hydrochloride. Methylene bisacrylamide.Nesse estudo, preparamos hidrogéis de polivinilpirrolidona/ácido acrílico(PVP/AA), sensíveis ao pH, por meio de método de polimerização de radical livre, com variações no conteúdo de monômero, de polímero e de agente de ligação cruzada. O inchamento foi realizado em soluções tampão fosfato USP pH 1,2, 5,5, 6,5 e 7,5, com força iônica constante. A estrutura reticular foi avaliada por diferentes parâmetros e o FTIR confirmou a formação de hidrogéis de ligação cruzada. A cristalografia de raios X mostrou dispersão molecular do cloridrato de tramadol. Realizou-se estudo de liberação do fármaco em soluções tampão fosfato pH 1,2, 5,5 e 7,5 para amostras selecionadas. Observou-se que o inchamento e a liberação do fármaco dos hidrogéis podem ser modificados mudando-se a composição e o grau de ligação cruzada dos hidrogéis em estudo. O coeficiente de inchamento foi alto em pH mais altos, exceto para um deles com alto conteúdo de PVP. A liberação do fármaco aumentou com o aumento do pH do meio e do conteúdo em AA nos hidrogéis, enquanto que o aumento na concentração do agente de ligação cruzada apresentou efeito oposto. A análise do mecanismo de liberação do fármaco revelou transporte não Fickiano do tramadol dos hidrogéis.

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Section: Fourier Transform Infrared (Ftir) Spectroscopymentioning

confidence: 97%

pH-sensitive polyvinylpyrrolidone-acrylic acid hydrogels: Impact of material parameters on swelling and drug release

Sohail

Khan

Shahzad

et al. 2014

Braz. J. Pharm. Sci.

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“…Owing to their super strong water absorption ability, they have been extensively used in agriculture and forestry, construction, medical [4,5] and public health, and daily life supplies [6][7][8][9]. In fact,~90% of superabsorbent hydrogels are disposable products [10,11], and most of them are synthesized by the graft copolymerization between hydrophilic monomers with double bond such as acrylic acid (AA) and acrylamide (AM).…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characteristics of Corn Straw-Co-AMPS-Co-AA Superabsorbent Hydrogel

Cheng

Wang

et al. 2015

Polymers

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Abstract:In this study, the corn straw after removing the lignin was grafted with 2-acrylamido-2-methylpropanesulfonic acid (AMPS) to prepare sulfonated cellulose. The grafting copolymerization between the sulfonated cellulose and acrylic acid (AA) was performed using potassium persulfate and N,N 1 -methylenebisacrylamide as the initiator and crosslinking agent, respectively, to prepare corn straw-co-AMPS-co-AA hydrogels. The structure and properties of the resulting hydrogels were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, scanning electron microscopy, thermogravimetric analysis, and dynamic rheometry. The effects of initiator, crosslinker, monomer neutralization degree, and temperature on the swelling ratio of the hydrogels were studied. The water retention, salt resistance, and recyclability of the corn straw-co-AMPS-co-AA hydrogels were also investigated. The optimum water absorptivity of the corn straw hydrogels was obtained at a polymerization temperature of 50˝C with 1.2% crosslinker, 1:7 ratio of the pretreated corn straw and AA, 2% initiator, and 50% neutralized AA.

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“…The semi-IPN hydrogels showed a lower swelling capacity of 13 g/g at pH 2, and then abruptly jump to 120 g/g around pH 4. This behavior was typical property of pH-sensitive hydrogel [19]. The COO -groups were protonated to form COOH groups when pH was lower than 4 due to the pKa of 4.25 of -COOH [20], thus the hydrogen between the carboxylic groups and the amide groups kept polymer chains of the hydrogels close to each other and restricted the expansion of the network.…”

Section: Swelling Of Semi-ipn Hydrogels -Effect Of Phmentioning

confidence: 94%

Preparation and swelling behavior of pH-sensitive and saltresistant amphoteric semi-IPNs hydrogels based on starch phosphate and poly[2-[(methacryloyloxy) ethyl] trimethylammonium] chloride

Chen¹,

Xu²,

Feng³

et al. 2010

E-Polymers

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Abstract:A novel amphoteric hydrogel with semi-interpenetrating polymer networks (semi-IPNs), was prepared by entrapping linear poly[2-[(methacryloyloxy) ethyl]trimethylammonium] chloride (PDMC) into lightly crosslinked starch phosphate-graft-acrylic acid (St-OPO 3 -g-AA) network in aqueous solution. The influences including the degree of substitution (DS) of starch phosphate, the doses of crosslinker, AA and PDMC were investigated with respect to the swelling capacity. The swelling capacity of hydrogel reached 2016 g/g in deionized water and 121 g/g in 0.9 wt% NaCl solutions, respectively. The swelling behaviors of hydrogel in various salt solutions and different pH buffer solutions were discussed. The amphoteric semi-IPN hydrogels exhibited pH-sensitivity and salt-resistance.

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Synthesis and characterization of pH-sensitivity semi-IPN hydrogel based on hydrogen bond between poly(N-vinylpyrrolidone) and poly(acrylic acid)

Cited by 141 publications

References 23 publications

pH-sensitive polyvinylpyrrolidone-acrylic acid hydrogels: Impact of material parameters on swelling and drug release

pH-sensitive polyvinylpyrrolidone-acrylic acid hydrogels: Impact of material parameters on swelling and drug release

Preparation and Characteristics of Corn Straw-Co-AMPS-Co-AA Superabsorbent Hydrogel

Preparation and swelling behavior of pH-sensitive and saltresistant amphoteric semi-IPNs hydrogels based on starch phosphate and poly[2-[(methacryloyloxy) ethyl] trimethylammonium] chloride

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