Synthesis and Characterization of pH‐sensitive Poly(IA‐<i>co</i>‐AAc‐<i>co</i>‐AAm) Hydrogels via Frontal Polymerization

Irfan, Muhammad; Du, Xiang‐Yun; Xu, Xu Ran; Shen, R.; Chen, Su; Xiao, Jianjun

doi:10.1002/pola.29502

Cited by 10 publications

(13 citation statements)

References 59 publications

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“…Finally, because of its highly microporous structure, the hydrogel crosslinked with N,N′-methylene-bisacrylamide showed a higher drug release rate compared to the counterparts crosslinked with the other crosslinkers. Irfan and co-workers [58] exploited frontal polymerization for synthesizing a series of poly(itaconic acid-co-acrylic acid-co-acrylamide) hydrogels suitable for drug delivery purposes. More specifically, the effects of the itaconic acid/acrylic acid weight ratio (changing from 1:39 to 5:35 wt/wt) on the front temperatures and velocities were thoroughly investigated.…”

Section: Drug Deliverymentioning

confidence: 99%

Polymer Hydrogels and Frontal Polymerization: A Winning Coupling

Mariani,

Malucelli

2023

Polymers

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Polymer hydrogels are 3D networks consisting of hydrophilic crosslinked macromolecular chains, allowing them to swell and retain water. Since their invention in the 1960s, they have become an outstanding pillar in the design, development, and application of engineered polymer systems suitable for biomedical and pharmaceutical applications (such as drug or cell delivery, the regeneration of hard and soft tissues, wound healing, and bleeding prevention, among others). Despite several well-established synthetic routes for developing polymer hydrogels based on batch polymerization techniques, about fifteen years ago, researchers started to look for alternative methods involving simpler reaction paths, shorter reaction times, and lower energy consumption. In this context, frontal polymerization (FP) has undoubtedly become an alternative and efficient reaction model that allows for the conversion of monomers into polymers via a localized and propagating reaction—by means of exploiting the formation and propagation of a “hot” polymerization front—able to self-sustain and propagate throughout the monomeric mixture. Therefore, the present work aims to summarize the main research outcomes achieved during the last few years concerning the design, preparation, and application of FP-derived polymeric hydrogels, demonstrating the feasibility of this technique for the obtainment of functional 3D networks and providing the reader with some perspectives for the forthcoming years.

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Section: Drug Deliverymentioning

confidence: 99%

Polymer Hydrogels and Frontal Polymerization: A Winning Coupling

Mariani,

Malucelli

2023

Polymers

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“…Similar structural roughness and heterogeneity with porous network structure of the polymer matrix was found after the modification of dextran with itaconic acid/butyl methacrylate. [29,30] AFM image of AIG-cl-carbopol-co-poly (AAm) revealed the 25.78 nm root mean square roughness while the average surface roughness was 19.23 nm (Figure 1B). The surface roughness controls the mucoadhesion, which makes the drug delivery carrier site-specific.…”

Section: Characterizationmentioning

confidence: 99%

Design of moxifloxacin encapsulated network hydrogel wound dressings: Evaluation of polymer‐drug, polymer‐blood, and polymer‐bio membrane interactions

Singh

Sharma

Ram

2022

Polymer Engineering & Sci

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It is an exploration of the inherent wound-healing tendency of Azadirachta indica gum (AIG) or neem gum polysaccharides to develop the hydrogel wound dressings with enhanced potential during wound management. Herein this research work, antibiotic moxifloxacin encapsulated AIG network copolymeric hydrogels were developed by functionalizing with carbapol and poly(acrylamide) [poly(AAm)] for better wound healing. The polymer-drug, polymer-blood, and polymer-bio membrane interactions were evaluated in biomedical properties. The copolymeric network structure was confirmed by scanning electron micrographs (SEMs), atomic force microscopy (AFM), Fourier transform infrared spectroscopy (FTIR), and 13 C solid-state nuclear magnetic resonance (NMR) spectroscopy. The results confirmed sustained release of the moxifloxacin with diffusion by non-Fickian process and Korsmeyer-Peppas kinetic model in the phosphate buffer saline (PBS). These interactions inferred the blood-compatible (hemolytic index 3.41 ± 0.70%) and mucoadhesive nature (polymer-biomembrane detachment force 0.09 ± 0.01 mN) of hydrogel dressing. The per gram of hydrogel dressings absorbed 10.22 ± 0.23 g of simulated wound fluid which is very useful to maintain moist wound environment for better wound healing. All these interactions and properties indicated the suitability of the hydrogel material for wound dressing applications for better wound care.

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“…Compared with other polymerization methods, FP has process advantages such as shorter time, lower energy consumption, and no waste emission 21 . In recent years, frontal polymerization has synthesized numerous polymer hydrogels, such as poly (itaconic acid-acrylic acid-acrylamide) hydrogels 22 and poly (acrylic acid-acrylamide) / activated carbon 23 .…”

Section: Prefacementioning

confidence: 99%

Preparation of novel β-CD/P(AA-co-AM) hydrogels by frontal polymerization

Qin

et al. 2022

Preprint

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In this paper, betaine (Bet) was used as a hydrogen bond acceptor (HBA), acrylic acid (AA) and acrylamide (AM) were used as hydrogen bond donors (HBD) and mixed to form a deep eutectic solvent (DES). Different concentrations of β-cyclodextrin (β-CD) were dispersed in DES, and a novel β-CD/P(AA-Co-AM) hydrogel was prepared by frontal polymerization (FP). Characteristic structure and morphology of the hydrogels were analyzed using Fourier infrared spectroscopy (FTIR) and scanning electron microscopy (SEM), and the properties of the hydrogels were investigated. The results show that the mechanical properties of the hydrogel were improved by β-CD acting as a second cross-linking agent in the polymerization process, thus increasing the cross-link density of the hydrogel. Because the carboxyl groups contained in acrylic acid dissociate under alkaline conditions, the composite hydrogel shows excellent pH responsiveness under alkaline conditions. Tetracycline hydrochloride was used as a drug model to test the drug loading and drug release performance of hydrogels. With the increase of β-CD content, the loading capacity of hydrogels to tetracycline hydrochloride gradually increased. The data of drug release indicated that the hydrogel has good drug delivery performance and has promising applications in drug delivery systems and other areas.

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Synthesis and Characterization of pH‐sensitive Poly(IA‐co‐AAc‐co‐AAm) Hydrogels via Frontal Polymerization

Cited by 10 publications

References 59 publications

Polymer Hydrogels and Frontal Polymerization: A Winning Coupling

Polymer Hydrogels and Frontal Polymerization: A Winning Coupling

Design of moxifloxacin encapsulated network hydrogel wound dressings: Evaluation of polymer‐drug, polymer‐blood, and polymer‐bio membrane interactions

Preparation of novel β-CD/P(AA-co-AM) hydrogels by frontal polymerization

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