Synthesis and characterization of pH-sensitive hydrogel composed of carboxymethyl chitosan for colon targeted delivery of ornidazole

Vaghani, Subhash S.; Patel, Madhabhai M.; Satish, C. S.

doi:10.1016/j.carres.2011.04.048

Cited by 134 publications

(47 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Besides, the natural polymers are cheap as compared to the synthetic polymers. Some of the well-known natural polymers used for the preparation of hydrogels include cellulose [10] , starch [11] , chitosan [12] , sodium alginate [13] , guar gum [8] , gellan gum [14] and xanthan gum [7] .…”

Section: Research Papermentioning

confidence: 99%

Citric Acid Crosslinked Carboxymethyl Cellulose-based Composite Hydrogel Films for Drug Delivery

Mali¹,

Dhawale²,

Dias³

et al. 2018

pharmaceutical-sciences

View full text Add to dashboard Cite

Mali et al.: Carboxymethyl cellulose-based hydrogel films for drug deliveryThe objective of this study was to synthesize and characterize citric acid crosslinked hydrogel films of carboxymethyl cellulose-tamarind gum for topical drug delivery. The hydrogel films were characterized by attenuated total reflectance-Fourier-transform infrared spectroscopy, solid-state 13 C-nuclear magnetic resonance spectroscopy and differential scanning calorimeter. The prepared hydrogel films were evaluated for the carboxyl content and equilibrium swelling ratio. Moxifloxacin hydrochloride was loaded into these hydrogel films and drug release was monitored in the phosphate buffer pH 7.4. Haemolysis assay was used to study biocompatibility of hydrogel films. Results of the attenuated total reflectance-Fourier-transform infrared spectroscopy, solid-state 13 C-nuclear magnetic resonance and differential scanning calorimeter confirmed the formation of citric acid-crosslinked hydrogel films. Total carboxyl content of hydrogel film was found to be increased when polymer ratio and amount of citric acid was increased. In contrast, swelling of hydrogel film was found to be decreased with increase in polymer ratio and amount of citric acid. Batch B1 showed highest drug loading with non-Fickian release mechanism. All remaining batches showed nonFickian release behavior with diffusion coefficient greater than 0.5. Results of haemolysis assay indicated that the citric acid crosslinked carboxymethyl cellulose-tamarind gum hydrogels were safe to be used in drug delivery. These results indicated that the citric acid crosslinked carboxymethyl cellulose-tamarind gum composite hydrogel film has the potential to be used in topical novel drug delivery systems.

show abstract

Section: Research Papermentioning

confidence: 99%

Citric Acid Crosslinked Carboxymethyl Cellulose-based Composite Hydrogel Films for Drug Delivery

Mali¹,

Dhawale²,

Dias³

et al. 2018

pharmaceutical-sciences

View full text Add to dashboard Cite

show abstract

“…For instance, the hydrogel showed 12 % swelling at pH 1.2, 97 % swelling at pH 6.8, and 118 % swelling at pH 7.4. Also, the study demonstrated that the degree of deacetylation and the extent of carboxyl substitution can also affect the extent of swelling [65]. This property makes it an attractive candidate as stimuli-responsive drug delivery system.…”

Section: Chemically Crosslinked Hydrogels Using Exogenous Crosslinkersmentioning

confidence: 97%

“…Due to the high reactivity of GA, highly crosslinked gel can be obtained by this process [63]. Vaghani et al developed a pH-responsive hydrogel from carboxymethyl chitosan, which is known to have antibacterial properties and show solubility over a wide range of pH [64,65]. Carboxymethylchitosan can be prepared by a high-temperature reaction of chitosan with monochloroacetic acid in sodium hydroxide/isopropyl alcohol.…”

Section: Chemically Crosslinked Hydrogels Using Exogenous Crosslinkersmentioning

confidence: 98%

Chitosan Hydrogels for Regenerative Engineering

Padmanabhan

Nair

2015

Springer Series on Polymer and Composite Materials

View full text Add to dashboard Cite

Research in the field of hydrogels has been actively growing for the past couple of decades. Hydrogels are crosslinked polymers with high water content. They can be prepared from natural, synthetic, and composite polymers using different chemical and physical crosslinking methods. Hydrogels have been widely explored for the delivery of bioactive molecules, drugs, and for other therapeutic applications. Chitosan-based hydrogels have unique advantages owing to their biocompatibility, biodegradability, antimicrobial activity, mucoadhesivity, and low toxicity. This chapter reviews the different methods used for preparing chitosan-based hydrogels and their applications as cell, protein, and drug delivery vehicles to support tissue regeneration.

show abstract

“…In recent times, various modified polysaccharidebased hydrogels have been developed and reported for colon-targeted drug delivery (Davaran et al 1999;Ganguly et al 2011;Vaghani et al 2012;Wiwattanapatapee et al 2003). Although various hydrogel systems have been reported for the sustained release of ornidazole, still it is imperative to develop a new and novel ornidazole carrier because of the important shortcomings of available hydrogels, considering the specificity, biodegradability, biocompatibility, drug stability and sustained release characteristics (Das et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Novel pH-responsive graft copolymer based on HPMC and poly(acrylamide) synthesised by microwave irradiation: application in controlled release of ornidazole

Das

Ghosh

et al. 2014

Cellulose

View full text Add to dashboard Cite

Herein, the microwave-assisted grafting method was employed for the development of a novel pH-responsive graft copolymer derived from polyacrylamide-modified hydroxypropyl methyl cellulose [g-HPMC (M)]. The synthesised copolymer has been used for in vitro sustained release of ornidazole. Various characterizations confirm the formation of graft copolymer. Swelling studies indicate the pHdependent swelling behaviour, while deswelling studies suggest that g-HPMC (M) shows faster deswelling in response to change in pH and/temperature. The cell viability study signifies that g-HPMC (M) is cytocompatible. The in-vitro release study demonstrates that g-HPMC (M) delivers ornidazole specifically in the colon pH, without release of the drug in the acidic environment, ensuring g-HPMC (M) as an ideal candidate for orally administered colonic drug carriers. The kinetics and mechanism of drug release suggest that it follows a non-Fickian release mechanism.

show abstract

Synthesis and characterization of pH-sensitive hydrogel composed of carboxymethyl chitosan for colon targeted delivery of ornidazole

Cited by 134 publications

References 23 publications

Citric Acid Crosslinked Carboxymethyl Cellulose-based Composite Hydrogel Films for Drug Delivery

Citric Acid Crosslinked Carboxymethyl Cellulose-based Composite Hydrogel Films for Drug Delivery

Chitosan Hydrogels for Regenerative Engineering

Novel pH-responsive graft copolymer based on HPMC and poly(acrylamide) synthesised by microwave irradiation: application in controlled release of ornidazole

Contact Info

Product

Resources

About