Synthesis and characterization of PCL-DA:PEG-DA based polymeric blends grafted with SMA hydrogel as bio-degradable intrauterine contraceptive implant

Subramanian, Bhuvaneshwaran; Agarwal, Tarun; Roy, Arpita; Parida, S.C.; Kundu, Biswanath; Maiti, Tapas K.; Basak, Piyali; Guha, Sujoy K.

doi:10.1016/j.msec.2020.111159

Cited by 16 publications

(11 citation statements)

References 37 publications

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“…The estrogen and progesterone are encapsulated in PCL, and the intrauterine contraceptive device with a shape that can be adapted to the body's structure is prepared by fused deposition modeling. As a linearly synthesized degradable aliphatic polyester, PCL possesses high mechanical strength, plasticity, biocompatibility, and low degradation rate, while its degradation products are completely metabolized by the tricarboxylic acid cycle or directly excreted by the kidneys, which makes it suitable for long-term carrier implantation in vivo [ 28 , 116 ]. In addition, PCL has been approved by the U.S. FDA for drug delivery system applications with a good drug delivery structure and stable drug release rate [ 9 ].…”

Section: Advanced Biomaterials For Contraception By Various Routesmentioning

confidence: 99%

“…However, the only one case was the majority of the embolic agent immediately extruded from the oviduct into the uterus, and histological analysis showed varying degrees of occlusion, fibrosis, and inflammation. Subramanian et al represented an innovative insight into the use of a hydrogel formulation composed of styrene-cis-butylene-based styrene maleic anhydride (SMA) dissolved in dimethyl sulfoxide (DMSO) to make a non-hormonal tubal contraceptive implant [ 129 ]. Polymeric hydrogels cause sperm inactivation by lowering the pH of the surrounding environment to disrupt the acrosome.…”

Section: Advanced Biomaterials For Contraception By Various Routesmentioning

confidence: 99%

“…Meanwhile, the hydrogel implanted in the isthmus of the uterus did not show any implantation swelling, dilation, arrest, contraction, or signs of abnormal growth on the outer surface compared to the control group (Fig. 9 ) [ 129 ].

Fig.…”

Section: Advanced Biomaterials For Contraception By Various Routesmentioning

confidence: 99%

“…B The characterizations of polymer containing cooling and heating curves, X-ray diffraction peak patterns, and thermogravimetric analysis. C Immunohistochemical evaluation of rat uterine tissues compared with control and treated groups (Reprinted with permission from reference [ 129 ]. Copyright 2020 Elsevier, Ltd) …”

Section: Advanced Biomaterials For Contraception By Various Routesmentioning

confidence: 99%

“…11 ) [ 29 ]. Sodium alginate, a natural macromolecular material with excellent biocompatibility, can be guided by GDL to form an injectable system with calcium-containing substances [ 28 ]. Calcium alginate hydrogel is considered a long-term physical barrier for sperm and retains its good biocompatibility properties.…”

Section: Advanced Biomaterials For Contraception By Various Routesmentioning

confidence: 99%

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Recent progress in advanced biomaterials for long-acting reversible contraception

Yan

Zhang

et al. 2022

J Nanobiotechnol

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Unintended pregnancy is a global issue with serious ramifications for women, their families, and society, including abortion, infertility, and maternal death. Although existing contraceptive strategies have been widely used in people's lives, there have not been satisfactory feedbacks due to low contraceptive efficacy and related side effects (e.g., decreased sexuality, menstrual cycle disorder, and even lifelong infertility). In recent years, biomaterials-based long-acting reversible contraception has received increasing attention from the viewpoint of fundamental research and practical applications mainly owing to improved delivery routes and controlled drug delivery. This review summarizes recent progress in advanced biomaterials for long-acting reversible contraception via various delivery routes, including subcutaneous implant, transdermal patch, oral administration, vaginal ring, intrauterine device, fallopian tube occlusion, vas deferens contraception, and Intravenous administration. In addition, biomaterials, especially nanomaterials, still need to be improved and prospects for the future in contraception are mentioned. Graphical Abstract

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Section: Advanced Biomaterials For Contraception By Various Routesmentioning

confidence: 99%

Section: Advanced Biomaterials For Contraception By Various Routesmentioning

confidence: 99%

Fig.…”

Section: Advanced Biomaterials For Contraception By Various Routesmentioning

confidence: 99%

Section: Advanced Biomaterials For Contraception By Various Routesmentioning

confidence: 99%

Section: Advanced Biomaterials For Contraception By Various Routesmentioning

confidence: 99%

See 3 more Smart Citations

Recent progress in advanced biomaterials for long-acting reversible contraception

Yan

Zhang

et al. 2022

J Nanobiotechnol

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Reversible Mechanical Contraception and Endometriosis Treatment Using Stimuli‐Responsive Hydrogels

Anthis,

Kilchenmann,

Murdeu

et al. 2024

Advanced Materials

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Female sterilization via fallopian tube ligation is a common procedure. However, after the operation, over 10% of women seek re‐fertilization, which is frequently unsuccessful. In addition, there is evidence that fallopian tubes contribute to the spread of endometriotic tissue as they serve as channels for proinflammatory media entering the abdominal cavity via retrograde menstruation. Here, we present stimuli‐degradable hydrogel implants for the functional, biocompatible, and reversible occlusion of fallopian tubes. The hydrogel implants, designed with customized swelling properties, mechanically occlude fallopian tubes in a high‐performance manner with burst pressures reaching 255–558 mmHg, exceeding normal abdominal pressures (95 mmHg). Their damage‐free removal can be achieved within 30 minutes using near‐visible UV light or a glutathione solution, employing a method akin to standard fallopian tube perfusion diagnostics. We demonstrate ultrasound‐guided implant placement using a clinical hysteroscope in a human‐scale uterus model and biocompatibility in a porcine in vivo model. Importantly, the prevention of live sperm as well as endometrial cell passage through blocked fallopian tubes is demonstrated. Overall, we present a multifunctional system that constitutes a possible means of on‐demand, reversible contraception along with the first ever mechanical approach to abdominal endometriosis prevention and treatment.This article is protected by copyright. All rights reserved

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Biocompatible poly(glycerol sebacate) base segmented co‐polymer with interesting chemical structure and tunable mechanical properties: In vitro and in vivo study

Arabsorkhi‐Mishabi

Zandi

Askari

et al. 2023

J of Applied Polymer Sci

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In this study, different polycaprolactone (PCL) soft blocks were incorporated into poly(glycerol sebacate) (PGS) structure to prepare a series of PGS‐based elastomers with a wide range of chemical compositions, mechanical properties, and modulated degradation behavior. The PGS and PGS‐co‐PCL elastomers were prepared under a thermal curing process in the absence of any catalysts. Here, in addition to the effect of different lengths of PCL block, the effect of thermal curing time on the mechanical properties and degradation behavior of the elastomers was investigated. The synthesized PGS‐co‐PCL elastomers exhibited tunable mechanical properties in the range of soft tissues. Moreover, the in vitro degradation study revealed linear degradation kinetics with approximately twofold decrease in the elastomers degradation rate. In vitro study showed that proliferation of human olfactory ecto‐mesenchymal stem cells (OE‐MSCs) was supported on PGS‐co‐PCL elastomer. In addition, in vivo evaluation of PGS‐co‐PCL elastomer confirmed mild tissue response with high angiogenesis, indicating a good candidate in various biomedical applications and soft tissue engineering.

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Synthesis and characterization of PCL-DA:PEG-DA based polymeric blends grafted with SMA hydrogel as bio-degradable intrauterine contraceptive implant

Cited by 16 publications

References 37 publications

Recent progress in advanced biomaterials for long-acting reversible contraception

Recent progress in advanced biomaterials for long-acting reversible contraception

Reversible Mechanical Contraception and Endometriosis Treatment Using Stimuli‐Responsive Hydrogels

Biocompatible poly(glycerol sebacate) base segmented co‐polymer with interesting chemical structure and tunable mechanical properties: In vitro and in vivo study

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