Synthesis and characterization of novel poly(acrylamide‐co‐acrylic acid‐co‐2‐hydroxy ethyl actylate) hydrogels: Mathematical approach in investigation of swelling kinetics and diffusion models

Abstract

In this study, a series of poly(acrylamide-coacrylic acid-co-2-hydroxy ethyl actylate) [AM-co-AA-co-HEA] hydrogels have been synthesized by varying the acrylic acid (AA)content over eightfold in feed in the range of 33.34-93.76% by keeping other monomer constant. These hydrogels were characterized by FTIR, SEM analysis, elemental analysis, residual acrylic acid analysis, network parameters, and dynamic swelling behavior. The swelling study showed that equilibrium swelling ratio was nonlinearly increased with increasing AA content. Interestingly, the equilibrium swelling ratio decreased from 53.42 to 48.52 for 75-80% AA content hydrogel. The swelling data were found to satisfactorily fit Fick's second law, demonstrating that diffusion rate of water uptake was primarily Fickian.From model fitting, it was observed that early model was applicable for first 30% water absorption, and late model was applicable for latter 70% water absorption for increasing AA content from 33.34-90.90%. For 93.76% AA, early-time model was extended up to first 50% of water absorption and late model was contracted for latter 50% water absorption, indicating that excessive AA content affects the applicability range of early-time and late-time diffusion models for water absorption. Etters model was best applicable to all type of hydrogels and followed over all swelling range.

Smart capsule for non-invasive sampling and studying of the gastrointestinal microbiome

“…[26][27][28][29][30][31][32][33] Super-absorbent hydrogels, typically based on the polymerization of acrylic acid and acrylamide, have been shown to absorb 150-300 times their weight in most aqueous environments. 34,35 By taking advantage of the hydrogel's absorption capacity, as well as their mechanical properties, it is possible to design a non-invasive sampling device which can passively extract and secure samples taken from otherwise unreachable areas of the GI tract. As shown in Fig.…”

Synthesis and characterization of novel pH‐responsive poly(2‐hydroxylethyl methacrylate‐co‐N‐allylsuccinamic acid) hydrogels for drug delivery

“…2‐Hydroxyethyl methacrylate (HEMA) hydrogels are biocompatible hydrogels . The tunable mechanical features, chemical stability, and especially high biocompatibility of hydrogels containing HEMA have made HEMA a favorite of researchers . HEMA is generally prepared in the form of copolymer hydrogels with ionic or more hydrophilic monomers.…”