Synthesis and characterization of novel 7-hydroxycoumarin derivatives

Synthesis, characterization and photophysical studies of dual-emissive base-modified fluorescent nucleosides

“…38 Thereafter, six coumarin based dihydro[1,3]-oxazines were synthesized in 72–86% yields by following the Mannich-type condensation reaction of 7-hydroxy-4-azidomethylcoumarin 4 with formaldehyde and primary amines 5a–f in 1,4-dioxane at 100 °C, as described in Scheme 2. 39…”

Synthesis of new coumarin[1,3]oxazine derivatives of 7‐hydroxy‐6‐isobornyl‐4‐methylcoumarin and their antioxidant activity

“…It is known that the synthesis of dihydrobenzoxazines is a two‐stage process (Mostafavi et al, 2013; Nagorichna et al, 2007). In the first stage, the reaction of formaldehyde with the corresponding primary amine results in the in situ formation of N , N ‐di(hydroxymethyl)amine.…”