Synthesis and Characterization of New Complexes of (N-P-Amino Diphenyl Amine) Amino (2-Hydroxy Phenyl) Acetonitrile Ligand with Some Transition Metal Ions

Alabdali, Ammar J.

doi:10.9790/5736-0320510

Cited by 4 publications

(3 citation statements)

References 47 publications

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“…The complexes appear to dissipate and the band (NH) vanishes due to coordination and frequency shifts (C=O) and the other ranges are summarized in Table 5. The (π π*) transition produces a broad peak at 260-300 nm, while the (n π*) transition produces a narrow peak at 420 nm in UV-Vis ligand spectra [24]. The charge transfers in the UV region, as well as the d-d transition for the Co +2 complex at 625 nm for the type 4 T1g 4 T1gP complex, are indicated, as the d-d transitions for the Ni +2 complex at 576 and 602 nm for the type 4 T1 4 T2 and 4 T1 4 T1P complex, and the d-d transition for the Cu +2 complex at 785 [25] show nm type 2 E 2 T2.…”

Section: Results and Dissectionsmentioning

confidence: 99%

Untitled

2022

J. Med. Chem. Sci.

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By condensation reaction between P-amino benzoic acid and ethanol in the presence of concentrated H2SO4 to produce ethyl 4-aminobenzoate, which was then converted into N, N'-(1,2-phenylene) bis(4-aminobenzamide) type [H2L] (N2O2) product by direct interaction between the two reactive molecules of this product with one molecule of 1,2-Benzene diamine, as a new series of metal conversion complexes of Co(II), Ni(II), and Cu(II). The prepared ligand and their complexes characterized in the solid and solution states using spectroscopic techniques such as UV-Vis, FT.IR, 1 HNMR, and the elemental analyses as well as melting temperatures, molar conductivity, and magnetic susceptibility. The octahedral geometry around the central metal is suggested by molar conductivity, magnetic moment, molar ratio, and spectroscopic data about copper and cobalt ions, while tetrahedral around the nickel ion. After the incubation period at 37 °C for 24 h, the biological behavior of the binding produced with its anti-bacterial compounds against (Staphylococcus aureus and Escherichia coli) was examined at different concentrations (10, 50, and 200) ppm. The results showed that the performance of the prepared compounds was better in resisting and reducing the growth of bacteria tested at high concentrations.

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Section: Results and Dissectionsmentioning

confidence: 99%

Untitled

2022

J. Med. Chem. Sci.

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“…47 3.1. The infrared spectrum of compound (3) showed the appearance of new characteristic band of υ C≡N group, 48,49 the presence of nitrile group indicated the formation of αamino nitrile compound (3) which derived from imine intermediate when reacted with HCN. The presence of nitrile group supported by chemical test as describe in experimental part.…”

Section: 12mentioning

confidence: 99%

Synthesis, characterization and anticancer activity of Ni(II), Cu(II), Pd(II) and Au(III) complexes derived from novel Mannich base

Manhee,

Alabdali

2024

Vietnam Journal of Chemistry

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New four complexes of Ni(II), Cu(II), Pd(II), and Au(III) were derived from the tridentate ligand 3‐((3‐(4‐hydroxyphenyl)‐5‐mercapto‐4H‐1,2,4‐triazol‐4‐yl)(3‐oxobutyl)amino)naphtho[2,3‐b]furan‐2(3H)‐one (L), which synthesized using condensation reaction of formaldehyde, acetone, and secondary amine (Mannich reaction). The secondary amine is a heterocyclic compound possesses two rings, naphthafuran and triazole, both rings prepared through intermolecular cyclization reactions. Considering that naphthafuran‐2‐one derived from α‐amino nitrile. The α‐amino nitrile compound contains the other triazole ring which illustrated to the structure through successive steps. The compounds were characterized using elemental analysis (C.H.N.S), FT‐IR, ultraviolet–visble spectroscopy, thermal gravimetric analysis (TGA), flame atomic absorption, molar conductivity, and magnetic susceptibility measurements. Accordingly, the probable geometries of the complexes were suggested as square planner, and they have electrolytic nature. Thus, chemical formula; [NiLCl]Cl·6H2O, [CuLCl]Cl·2H2O, [PdLCl]Cl·2H2O, and [AuLCl]Cl2·3H2O. Cytotoxic effect was studied on brain cancer cell line (AMJM cell line) at different concentrations for L and complexes. The results showed that gold(III) complex has the highest cytotoxicity among all compounds.

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“…The molecular docking approach can be used to model the interaction between a small molecule and a protein at the atomic level, which allow us to characterize the behavior of small molecules in the binding site of target proteins as well as to elucidate fundamental biochemical processes [18]. The docking process involves two basic steps: prediction of the ligand conformation as well as its position and …”

Section: Molecular Docking Studiesmentioning

confidence: 99%

Synthesis, Characterizations, Biological, and Molecular Docking Studies of Some Amino Acid Schiff Bases with Their Cobalt(II) Complexes

Salama¹,

Ahmed²,

Hassan³

2017

ABC

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The synthesis and structural characterization of cobalt(II) complexes of amino acid Schiff bases was prepared from Salicylaldehyde and three amino acid and magnetic susceptibility measurements. The electronic spectra of the metal complexes and their magnetic susceptibility measurements suggest octahedral structures are the probable coordination geometries for the isolated complexes. The Schiff bases and their metal complexes were preliminary scanned against various strains of microbes to study their biological effect.

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Synthesis and Characterization of New Complexes of (N-P-Amino Diphenyl Amine) Amino (2-Hydroxy Phenyl) Acetonitrile Ligand with Some Transition Metal Ions

Abstract: The synthesis and characterization of new complexes of Fe(II), Co(II), Ni(II)

Cited by 4 publications

References 47 publications

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Synthesis, characterization and anticancer activity of Ni(II), Cu(II), Pd(II) and Au(III) complexes derived from novel Mannich base

Synthesis, Characterizations, Biological, and Molecular Docking Studies of Some Amino Acid Schiff Bases with Their Cobalt(II) Complexes

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