Synthesis and Characterization of Naringenin-Loaded Chitosan-Dextran Sulfate Nanocarrier

Muralidharan, Shruthi; Shanmugam, Kumaran

doi:10.1007/s12247-020-09444-2

Cited by 15 publications

(14 citation statements)

References 56 publications

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“…The chitosan dextran sulfate NRG nanoparticles were spherical in shape, and their cytotoxic effects on breast cancer cell line (MCF-7) were evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay after 24 h incubation. The results indicated considerable cytotoxic activity of chitosan-dextran sulfate-NRG in addition to the controlled but rapid release of 80% of free NRG over 36 h. Hence, it seems that chitosan–dextran–sulfate–NRG nanocarrier is a suitable delivery system for NRG and other hydrophobic drugs [ 106 ].…”

Section: Nrg Nano-scaled Delivery Systemsmentioning

confidence: 99%

Naringenin Nano-Delivery Systems and Their Therapeutic Applications

et al. 2021

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Naringenin (NRG) is a polyphenolic phytochemical belonging to the class of flavanones and is widely distributed in citrus fruits and some other fruits such as bergamot, tomatoes, cocoa, and cherries. NRG presents several interesting pharmacological properties, such as anti-cancer, anti-oxidant, and anti-inflammatory activities. However, the therapeutic potential of NRG is hampered due to its hydrophobic nature, which leads to poor bioavailability. Here, we review a wide range of nanocarriers that have been used as delivery systems for NRG, including polymeric nanoparticles, micelles, liposomes, solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs), nanosuspensions, and nanoemulsions. These nanomedicine formulations of NRG have been applied as a potential treatment for several diseases, using a wide range of in vitro, ex vivo, and in vivo models and different routes of administration. From this review, it can be concluded that NRG is a potential therapeutic option for the treatment of various diseases such as cancer, neurological disorders, liver diseases, ocular disorders, inflammatory diseases, skin diseases, and diabetes when formulated in the appropriate nanocarriers.

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Section: Nrg Nano-scaled Delivery Systemsmentioning

confidence: 99%

Naringenin Nano-Delivery Systems and Their Therapeutic Applications

et al. 2021

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“…The encapsulation, loading efficiency, and yield are recorded in Table 2. The solubility of drugs in polymer suspension also controls the loading and encapsulation efficiency [56]. This loading capacity of nanoparticles is directly associated with the structural, physical, and chemical properties that permit the void area to load drugs into it [56].…”

Section: Encapsulation Efficiency Diosgenin Loading Yield Of Productionmentioning

confidence: 99%

“…The solubility of drugs in polymer suspension also controls the loading and encapsulation efficiency [56]. This loading capacity of nanoparticles is directly associated with the structural, physical, and chemical properties that permit the void area to load drugs into it [56]. The drug loading and encapsulation efficiency analysis can be considered to enhance the therapeutic potential of drugs.…”

Section: Encapsulation Efficiency Diosgenin Loading Yield Of Productionmentioning

confidence: 99%

Synthesis and Characterization of Diosgenin Encapsulated Poly-ε-Caprolactone-Pluronic Nanoparticles and Its Effect on Brain Cancer Cells

et al. 2021

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Diosgenin encapsulated PCL-Pluronic nanoparticles (PCL-F68-D-NPs) were developed using the nanoprecipitation method to improve performance in brain cancer (glioblastoma) therapy. The nanoparticles were characterized by dynamic light scattering (DLS)/Zeta potential, Fourier-transform infrared (FTIR) spectra, X-ray diffraction (XRD), Field Emission Scanning Electron Microscopy (FESEM), and Transmission electron microscopy (TEM). The encapsulation efficiency, loading efficiency, and yield were calculated. The in vitro release rate was determined, and the kinetic model of diosgenin release was plotted and ascertained. The cytotoxicity was checked by MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide)assay against U87-MG cells (glioblastoma cell lines). The obtained nanoparticles demonstrated good size distribution, stability, morphology, chemical, and mechanical properties. The nanoparticles also possessed high encapsulation efficiency, loading efficiency, and yield. The release rate of Diosgenin was shown in a sustained manner. The in vitro cytotoxicity of PCL-F68-D-NPs showed higher toxicity against U87-MG cells than free Diosgenin.

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“…Also, the line broadening appearing over 1652–1350 cm −1 reveals the covalent linkage of FA with BSA 22 . The formation of a hydrogen bond between the drug and the carrier is confirmed by a wide peak at 3500 cm −1 23 . The presence of some specific peaks of BSA, PEG, FA, and NRG in the final structure indicates the formation of BSA–PEG–FA–NRG–NPs.…”

Section: Resultsmentioning

confidence: 86%

Fabrication of bovine serum albumin‐polyethylene glycol nanoparticle conjugated‐folic acid loaded‐naringenin as an efficient carrier biomacromolecule for suppression of cancer cells

Firouzabadi

Karimi

Tabrizi

2022

Biotech and App Biochem

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Flavonoid compounds play an effective role in cancer suppression and today nanocarriers play an important role in improving the physicochemical properties and transmission of these compounds. In this study, polyethylene glycol‐modified albumin nanoparticles were synthesized by desolvation method; after loading of naringenin (NRG), folic acid (FA) binding to the surface of nanoparticles was performed (BSA–PEG–FA–NG–NPs). The extent of NRG trapping and FA binding was assessed indirectly using UV absorption methods. The physicochemical properties of BSA–PEG–FA–NG–NPs were investigated by DLS, SEM electron microscopy, and FTIR methods, after which their effects were evaluated on the apoptosis mechanism via MTT, flow cytometry, and qPCR methods. The BSA–PEG–FA–NG–NPs with spherical morphology had dimensions of 205 nm with zeta‐potential of 20.61 mV and dispersion index of 0.36. The NRG encapsulation was 84% and the FA binding was 75%. Anticancer effects of BSA–PEG–FA–NG–NPs were confirmed based on inhibiting breast cancer cells (IC50: 922 µg/ml), cell cycle arrest (SubG1 phase), and induction of apoptosis (upregulation of Caspase 3, 8, and 9).

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Synthesis and Characterization of Naringenin-Loaded Chitosan-Dextran Sulfate Nanocarrier

Cited by 15 publications

References 56 publications

Naringenin Nano-Delivery Systems and Their Therapeutic Applications

Naringenin Nano-Delivery Systems and Their Therapeutic Applications

Synthesis and Characterization of Diosgenin Encapsulated Poly-ε-Caprolactone-Pluronic Nanoparticles and Its Effect on Brain Cancer Cells

Fabrication of bovine serum albumin‐polyethylene glycol nanoparticle conjugated‐folic acid loaded‐naringenin as an efficient carrier biomacromolecule for suppression of cancer cells

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