Synthesis and characterization of N-(2-aminoethyl)-2-acetamidyl gellan gum with potential biomedical applications

Novac, Ovidiu Constantin; Lisă, Gabriela; Barbu, Eugen; Alhaique, Franco; Popa, Mihail

doi:10.1016/j.carbpol.2013.04.085

Cited by 10 publications

(4 citation statements)

References 7 publications

(7 reference statements)

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“…The need for polysaccharides with specific characteristics has motivated new ways to modify their original structure. Recently, chemical synthesis has been used to modify the structure of LAG (Coutinho et al ., ; Novac et al ., ; Karthika & Vishalakshi, ), but similar modifications on HAG have not been reported. In a previous investigation (Murillo‐Martínez & Tecante, ), a method to obtain a highly purified NaHAG and its characterisation and transition temperatures without addition of external counterion was reported.…”

Section: Introductionmentioning

confidence: 76%

Thermal stability and transition temperatures of monovalent salts of high‐acyl gellan gels

Murillo-Martínez

Tecante

2015

Int J of Food Sci Tech

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Thermogravimetry/derivative thermogravimetry (TG/DTG), rheometry and differential scanning calorimetry (DSC) were used to study the thermal stability and determine the transition temperatures of the sodium and potassium salts of high-acyl gellan (HAG) in the presence of 0-100 mM NaCl and KCl, respectively. TG/DTG revealed the potassium gellan (KHAG) gels to be more stable than those of sodium gellan (NaHAG), regardless of external cation concentration. Rheometry and DSC showed the melting (T m ) and gelling (T g ) temperatures to increase with cation concentration. The DSC peak temperatures showed thermal hysteresis contrary to rheometry. In most cases, DSC revealed KHAG to exhibit higher T m and T g than NaHAG. Consequently, thermal characteristics of NaHAG and KHAG gels depend on the size of the external cation and its ability to coordinate water molecules. Cation salts of HAG exhibit significantly lower transition temperatures than the commercial preparation from which they were produced.

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Section: Introductionmentioning

confidence: 76%

Thermal stability and transition temperatures of monovalent salts of high‐acyl gellan gels

Murillo-Martínez

Tecante

2015

Int J of Food Sci Tech

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“…The compounds were recrystallized from ethanol to give a pure product. 13 Structure of Proposed Synthesise Compound 14 Structure of proposed Synthesise compound chemical structure of (5-Imidazol-2-yl-4-Phenylpyrimidin-2-yl) [2-(2-Pyridylamino) Ethyl] Amine derivative as shown in Figure 1.…”

Section: Methodsmentioning

confidence: 99%

Synthesis, Characterization and Biological Evaluation of Glycogen Synthase Kinase-3β Inhibitors as Antidiabetic Agents

Mangaki,

Malviya

2023

IJPQA

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Diabetes is a substantially growing unhealthiest in the globe that causes severe morbidity and mortality. Currently a day’s there’s an imperative for the invention, development and improvement of novel antidiabetic drug molecules. A chain of compound (5-imidazol-2-yl-4-phenylpyrimidin-2-yl) [2-(2- pyridyl amino) ethyl] amine were developed and synthesized by using suitable chemical synthetic techniques. These recently synthesized derivatives were characterized with the help of modern analytical techniques. This compound was evaluated for glycogen synthase kinase-3 enzyme inhibitor activities for managing of polygenic disease. GSK-3 inhibitors may advance and emerge as a novel strategy for the management of diabetes.

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“…D'Arrigo et al covalently coupled GG with prednisolone, yielding a selfassembling nano-hydrogel that retained the anti-inflammatory properties of prednisolone 112 . Novac et al reported the synthesis of aminated carboxymethyl-GG derivatives 113 , targeted towards central nervous system drug delivery. This work was later extended to create an antibacterial GG hybrid that supported the controlled release of ciprofloxacin towards dermal repair applications 114 .…”

Section: Other Chemical Modificationsmentioning

confidence: 99%

Tissue engineering with gellan gum

et al. 2016

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Engineering complex tissues for research and clinical applications relies on high-performance biomaterials that are amenable to biofabrication, maintain mechanical integrity, support specific cell behaviours, and, ultimately, biodegrade. In most cases, complex tissues will need to be fabricated from not one, but many biomaterials, which collectively fulfill these demanding requirements. Gellan gum is an anionic polysaccharide with potential to fill several key roles in engineered tissues, particularly after modification and blending. This review focuses on the present state of research into gellan gum, from its origins, purification and modification, through processing and biofabrication options, to its performance as a cell scaffold for both soft tissue and load bearing applications. Overall, we find gellan gum to be a highly versatile backbone material for tissue engineering research, upon which a broad array of form and functionality can be built. Disciplines Engineering | Physical Sciences and Mathematics Publication DetailsStevens, L. R., Gilmore, K. J., Wallace, G. Engineering complex tissues for research and clinical applications relies on high-performance biomaterials that are amenable to biofabrication, maintain mechanical integrity, support specific cell behaviours, and, ultimately, biodegrade. In most cases, complex tissues will need to be fabricated from not one, but many biomaterials, which collectively fulfill these demanding requirements. Gellan gum is an anionic polysaccharide with potential to fill several key roles in engineered tissues, particularly after modification and blending. This review focuses on the present state of research into gellan gum, from its origins, purification and modification, through processing and biofabrication options, to its performance as a cell scaffold for both soft tissue and load bearing applications. Overall, we find gellan gum to be a highly versatile backbone material for tissue engineering research, upon which a broad array of form and functionality can be built.

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Synthesis and characterization of N-(2-aminoethyl)-2-acetamidyl gellan gum with potential biomedical applications

Cited by 10 publications

References 7 publications

Thermal stability and transition temperatures of monovalent salts of high‐acyl gellan gels

Thermal stability and transition temperatures of monovalent salts of high‐acyl gellan gels

Synthesis, Characterization and Biological Evaluation of Glycogen Synthase Kinase-3β Inhibitors as Antidiabetic Agents

Tissue engineering with gellan gum

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