Synthesis and characterization of metallophthalocyanine with morpholine containing Schiff base and determination of their antimicrobial and antioxidant activities

Ünlüer, Dilek; Kamiloğlu, Ayşe Aktaş; Direkel, Şahin; Bektaş, Ersan; Kanteki̇n, Hali̇t; Sancak, Kemal

doi:10.1016/j.jorganchem.2019.120936

Cited by 26 publications

(15 citation statements)

References 53 publications

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“…The compounds in this study showed higher antioxidant activity compared to the antioxidant activity results of the previously studied axially substituted silicon phthalocyanines (DPPH• SC50 values: DM-C3-Si: 19.9 µg/mL and DE-C3-Si: 23.2 µg/mL, FRAP TEAC values: DM-C3-Si: 232 μM and DE-C3-Si: 73 μM) (Aktaş Karaçelik et al, 2021). When antioxidant activity results of this study were compared with the previously tested PCs within the literature, the SiPcs were in agreement with the literature and even had better antioxidant activity than some PCs (Agirtaş et al, 2019;Günsel et al, 2019;Unluer et al, 2019;Günsel et al, 2020).…”

Section: Carbonic Anhydrase Inhibition and Antioxidant Activity Karbo...supporting

confidence: 82%

Carbonic anhydrase inhibition and antioxidant activity of the axially naphthoxazin group substituted silicon phthalocyanines

Karaçelik¹,

Çakır²,

Baş³

et al. 2021

Gümüşhane Üniversitesi Fen Bilimleri Enstitüsü Dergisi

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Silicon phthalocyanines are an interesting subclass of phthalocyanines. They are abundant and have extremely low toxicity levels. The low solubility of silicon phthalocyanine is the major obstacle to its use in many different applications. Therefore, in a previous study, two axially substituted silicon phthalocyanines were synthesized to increase their solubility. In this study, these axially substituted silicon phthalocyanines were evaluated for carbonic anhydrase inhibition and antioxidant activities. The carbonic anhydrase (CA) inhibition potential of silicon phthalocyanines was evaluated by esterase activity. The antioxidant activity was tested by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging and ferric ion (III) reducing/antioxidant power (FRAP) assays. The silicon phthalocyanines had significant CA inhibitory activity [50% inhibitory values (IC50): 495 ± 12.74 nM and 857 ± 13.03 nM for H4-Si and H3-Si, respectively]. According to the antioxidant studies, 50% scavenging concentration (SC50) values of DPPH• assay were 2.29 ± 0.06 µg/mL and 1.39 ± 0.43 µg/mL for H3-Si and H4-Si and Trolox Equivalent Antioxidant Capacity (TEAC) values of FRAP test were 259.33 ± 48.27 µM and 342.00 ± 44.40 for H3-Si µM and H4-Si, respectively. Consequently, silicon phthalocyanine compounds are considered to have great potential for their use in various fields such as food and medicine.

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Section: Carbonic Anhydrase Inhibition and Antioxidant Activity Karbo...supporting

confidence: 82%

Carbonic anhydrase inhibition and antioxidant activity of the axially naphthoxazin group substituted silicon phthalocyanines

Karaçelik¹,

Çakır²,

Baş³

et al. 2021

Gümüşhane Üniversitesi Fen Bilimleri Enstitüsü Dergisi

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“…The complexes showed MICs of~16 µg/mL on the selected species (e.g., C. glabrata ATCC 2001) but were not as effective as amphotericin B and ketoconazole. A series of zinc(II), copper(II) and cobalt(II) metallophthalocyanine (Pc) compounds derivatized with four 2-methoxy-4-{(Z)-[(4-morpholin-4-ylphenyl)imino]methyl}phenol at the peripheral positions (42, Figure 9) were reported by Unluer et al [109]. According to the in vitro studies, cobalt(II)Pc and copper(II)Pc complexes, in particular, showed antibacterial activities against S. typhimurium and E. coli.…”

Section: Ruthenium Complexesmentioning

confidence: 96%

Recent Studies on the Antimicrobial Activity of Transition Metal Complexes of Groups 6–12

Sovari

Zobi

2020

Chemistry

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Antimicrobial resistance is an increasingly serious threat to global public health that requires innovative solutions to counteract new resistance mechanisms emerging and spreading globally in infectious pathogens. Classic organic antibiotics are rapidly exhausting the structural variations available for an effective antimicrobial drug and new compounds emerging from the industrial pharmaceutical pipeline will likely have a short-term and limited impact before the pathogens can adapt. Inorganic and organometallic complexes offer the opportunity to discover and develop new active antimicrobial agents by exploiting their wide range of three-dimensional geometries and virtually infinite design possibilities that can affect their substitution kinetics, charge, lipophilicity, biological targets and modes of action. This review describes recent studies on the antimicrobial activity of transition metal complexes of groups 6–12. It focuses on the effectiveness of the metal complexes in relation to the rich structural chemical variations of the same. The aim is to provide a short vade mecum for the readers interested in the subject that can complement other reviews.

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“…The MIC values of 2 were 64 mg L −1 against E. coli , 128 mg L −1 against P. aeruginosa , 128 mg L −1 against L. pneumophila , 32 mg L −1 against E. hirae , 8 mg L −1 against E. fecalis , 32 mg L −1 against S. aureus , 8 mg L −1 against C. parapisilosis , and 32 mg L −1 against C. tropicalis . Unluer et al 66 studied the antimicrobial ability of synthesized Pc compounds and the highest antimicrobial abilities were found to be 625 mg L −1 (minimum inhibitory concentrations (MIC)) for E. coli and S. typhimurium . Our antimicrobial results demonstrated greater effectiveness than their findings.…”

Section: Biological Studiesmentioning

confidence: 99%

“…Our antimicrobial results demonstrated greater effectiveness than their findings. 66 There are also several investigations in which the antimicrobial abilities of Pcs against different microorganisms were studied. 34,67,68…”

Section: Biological Studiesmentioning

confidence: 99%

Novel axially symmetric and unsymmetric silicon(iv) phthalocyanines having anti-inflammatory groups: synthesis, characterization and their biological properties

et al. 2022

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Synthesis and characterization of metallophthalocyanine with morpholine containing Schiff base and determination of their antimicrobial and antioxidant activities

Cited by 26 publications

References 53 publications

Carbonic anhydrase inhibition and antioxidant activity of the axially naphthoxazin group substituted silicon phthalocyanines

Carbonic anhydrase inhibition and antioxidant activity of the axially naphthoxazin group substituted silicon phthalocyanines

Recent Studies on the Antimicrobial Activity of Transition Metal Complexes of Groups 6–12

Novel axially symmetric and unsymmetric silicon(iv) phthalocyanines having anti-inflammatory groups: synthesis, characterization and their biological properties

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