Synthesis and Characterization of Mercury Complex Derived from Trimesic Acid

Abstract

The effects of mercury complexes on human body and cells vary depending on the extent of exposure and their pharmacological form. Objectives: To characterize mercury complex and then investigate the effects on cellular interaction via cell death. Methods: The synthesis of the mercury complex was carried out, and its characterization was done by FTIR, elemental percentage and powder X-ray diffraction (PXRD). The complex was analyzed through atomic force microscopy (AFM) and by microscopy imaging its surface morphology and cellular interaction were also studied. Results: The presence of the mercury-complex results in cell death in concentration and time dependent manner. Conclusions: The synthesized mercury-complex has the ability to harm cells.

Synthesis and Characterization of Mercury Complex Derived from Trimesic Acid

“…Cantoni et al, also reported that exposure of cells with HgCl2 showed fast and continuous single strand breaks in DNA and it was dependent on duration and concentration of Hg used. Toxicity of HgCl2 under equivalent exposure resulted to cell death [31]. In current work, a new mercury complex based on TMA was utilized for cellular interaction investigation and cell death.…”