Synthesis and characterization of membranes obtained by graft copolymerization of 2-hydroxyethyl methacrylate and acrylic acid onto chitosan

Santos, Kátia Solange Cardoso Rodrigues dos; Coelho, Jorge F. J.; Ferreira, Paula; Pinto, Mariana; Lorenzetti, Solange Gubbelini; Ferreira, E. I.; Higa, Olga Zazuco; Gil, M.H.

doi:10.1016/j.ijpharm.2005.11.019

Cited by 96 publications

(41 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This is important because when considering our material for biological or/and medical use, it is evidently safe to be used at normal human body temperature 310 K (37 °C) and the compound is thermally stable. The present results are in harmony with previously published data [34,35]. In addition, a tinny inflexion was detected at 323 K (50 ¥ C) ( Figure 5) which could be attributed to the phase change of several crystalline zones of the PCL.…”

Section: Dynamic Mechanical Thermal Analysissupporting

confidence: 93%

“…Another peak, on the same Figure 5 is shown at 262.4 K (¡10.6 ¥ C) but this second is insensitive for frequency and is attributed to the crystallization. The present results are in harmony with previously published data [34,35]. In addition, a tinny inflexion was detected at 323 K (50 °C) ( Figure 5) which could be attributed to the phase change of several crystalline zones of the PCL.…”

Section: Dynamic Mechanical Thermal Analysissupporting

confidence: 93%

See 1 more Smart Citation

RETRACTED: A Bio Polymeric Adhesive Produced by Photo Cross-Linkable Technique

2016

View full text Add to dashboard Cite

Abstract:The advantages of photo polymerization methods compared to thermal techniques are: rapid cure reactions, low energy demands, solvent free requirements and room temperature use. In order to form a macromer, polycaprolactone (PCL) was cross-linked via ultraviolet power with 2-isocyanatoethyl methacrylate. Different methods of characterization were carried out: estimation of swelling capacity, adhesive capacity (using aminated substrates), surface energy (by contact angle), and attenuated total reflectance Fourier transform infrared. In addition to these experiments, we carried out dynamical mechanical thermal analysis, thermogravimetry and thermorphology characterizations of PCL. Thus, it has been concluded that the prepared macromer could be transformed into membranes that were effective as a medical adhesive. The degree of cross linking has been estimated using two different techniques: swelling of the samples and photo cross linking of the samples with different periods of irradiation at relatively high UV-power (600 mW/cm 2 ).

show abstract

Section: Dynamic Mechanical Thermal Analysissupporting

confidence: 93%

Section: Dynamic Mechanical Thermal Analysissupporting

confidence: 93%

RETRACTED: A Bio Polymeric Adhesive Produced by Photo Cross-Linkable Technique

2016

View full text Add to dashboard Cite

show abstract

“…In the scope of this work, the DMTA data were used to identify the thermal transitions of CO due to the modification with IPD. The DMTA was carried out in the Constrain Layer Damping Mode, following a methodology previously used by the same authors for different materials with high degree of success [30][31][32][33]. Fig.…”

Section: Thermal Propertiesmentioning

confidence: 99%

Modification of the biopolymer castor oil with free isocyanate groups to be applied as bioadhesive

Ferreira

Pereira

Coelho

et al. 2007

International Journal of Biological Macromolecules

Self Cite

133

View full text Add to dashboard Cite

Surgical adhesives have been used for several applications, including haemostasis, sealing air leakages and tissue adhesion. The aim of this work was to develop a biodegradable urethane-based bioadhesive containing free isocyanate groups. This material presents the advantage of being biodegradable, biocompatible and having the capacity of reacting with amino groups present in the biological molecules.A urethane based on castor oil (CO) was synthesized by reaction of the molecule with isophorone diisocyanate (IPD). The characterization of the material was accomplished by different techniques: ATR-FT-IR (attenuated transmittance reflection-Fourier transform infrared), swelling capacity determination, evaluation of the moisture curing kinetics, reaction with aminated substrates and determination of surface energy by contact angle measurement. The study of the urethane thermal properties was performed by DMTA (dynamical mechanical thermal analysis) and TGA (thermogravimetric analysis). The haemocompatibility of the urethane was also evaluated by thrombosis and haemolysis tests.

show abstract

“…During this work, the analyses were carried out in the constrain layer damping mode, which was previously used by the authors for different materials with good results Santos et al, 2006;Ferreira et al, 2006Ferreira et al, , 2007.…”

Section: Thermal Propertiesmentioning

confidence: 99%

Development of a new photocrosslinkable biodegradable bioadhesive

Ferreira

Coelho

Gil

2008

International Journal of Pharmaceutics

Self Cite

View full text Add to dashboard Cite

Adhesives provide a needle-free method of wound closure and do not require local anaesthetics. Polymeric adhesives have been used for about 3 decades for joining several tissues of the organism. Also, they can accomplish other tasks, such as haemostasis and the ability to seal air leakages and have the potential to serve as delivery systems.PCL was modified with 2-isocyanatoethylmethacrylate to form a macromer that was crosslinked via UV irradiation using Irgacure 2959 by CIBA ® as the photoinitiating agent. The characterization of the materials was accomplished by: attenuated total reflectance-Fourier transform infrared (ATR-FTIR), swelling capacity determination, evaluation of adhesive capacity (by reaction with aminated substrates) and determination of surface energy by contact angle measurement. Thermal characterization of the adhesive was performed by dynamical mechanical thermal analysis (DMTA) and thermogravimetric analysis (TGA). The morphology of PCL networks was observed using scanning electron microscopy (SEM) both after crosslinking process and following biodegradation in human plasma.The haemocompatibility of the membranes was also evaluated by thrombosis and haemolysis tests.

show abstract

Synthesis and characterization of membranes obtained by graft copolymerization of 2-hydroxyethyl methacrylate and acrylic acid onto chitosan

Cited by 96 publications

References 42 publications

RETRACTED: A Bio Polymeric Adhesive Produced by Photo Cross-Linkable Technique

RETRACTED: A Bio Polymeric Adhesive Produced by Photo Cross-Linkable Technique

Modification of the biopolymer castor oil with free isocyanate groups to be applied as bioadhesive

Development of a new photocrosslinkable biodegradable bioadhesive

Contact Info

Product

Resources

About