Synthesis and characterization of MCM-48/hydroxyapatite composites for drug delivery: Ibuprofen incorporation, location and release studies

Pajchel, Łukasz; Kołodziejski, Wacław

doi:10.1016/j.msec.2018.06.028

Cited by 46 publications

(11 citation statements)

References 43 publications

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“…The selection of a suitable or a more effective drug carrier depends on the loading capacity, release rate, biocompatibility of the product, safety, and production cost . The mesoporous forms of silica (MCM-41, MCM-48, and SBA-15) were studied extensively as promising drug delivery systems for different species of drugs . They are biocompatible materials that have high loading capacities, and the polarity of their surfaces facilitates the dissolution of the loaded drug into the bloodstream .…”

Section: Introductionmentioning

confidence: 99%

“…12 The mesoporous forms of silica (MCM-41, MCM-48, and SBA-15) were studied extensively as promising drug delivery systems for different species of drugs. 13 They are biocompatible materials that have high loading capacities, and the polarity of their surfaces facilitates the dissolution of the loaded drug into the bloodstream. 14 Unfortunately, the high production cost of the synthetic porous silica and the toxicity of some of their raw materials in addition to its production time make them unfavorable for the commercial and industrial scales.…”

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confidence: 99%

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Synthesis of Chitosan/Diatomite Composite as an Advanced Delivery System for Ibuprofen Drug; Equilibrium Studies and the Release Profile

et al. 2021

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Chitosan/diatomite nanocomposite (CS/D) was synthesized as a low-cost and highly porous structure of enhanced physicochemical properties to be applied as advanced carriers for ibuprofen drug (IB). The loading properties of CS/D were studied in comparison to diatomite as a separated phase and achieved a loading capacity of 562.6 mg/g. The loading reactions of IB into CS/D show pseudo-second-order kinetic behavior and Langmuir isotherm properties. This demonstrates homogeneous loading processes in monolayer forms and controlled essentially by physical mechanisms. This was confirmed by the calculated Gaussian energy (7.7 kJ/mol (D) and 7.9 kJ/mol (CS/D)) in addition to the thermodynamic parameters. The thermodynamic behavior for the IB loading process is related to spontaneous, favorable, and exothermic reactions. The CS/D composite is of promising IB release profile that extended to about 200 h with a maximum release of 91.5% at the gastric fluid (pH 1.2) and 97.3% in the intestinal fluid (pH 7.4). The IB release rate from CS/D can be controlled based on the ratio of the integrated chitosan in the composite. The IB release reactions from CS/D follow the assumption of Korsmeyer−Peppas kinetics with determined values for the diffusion exponent reflects complex diffusion and erosion as the affected mechanisms during the IB release process.

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

Synthesis of Chitosan/Diatomite Composite as an Advanced Delivery System for Ibuprofen Drug; Equilibrium Studies and the Release Profile

et al. 2021

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“…This study revealed that MSNs have high biocompatibility and high drug delivery efficiency [18]. Thanks to their many unique properties such as high surface area (1000 m 2 g -1 ) [45,49] adjustable particle shape, easy functionalization of the inner and outer surface, pore volume (1 cm 3 g -1 ) [45], which allows high drug loading, high thermal and chemical stability [50], high adsorption capacity [51] strength [52] and biocompatibility [19],…”

Section: Mesoporous Silica Nanoparticles (Msns)mentioning

confidence: 93%

“…In 2001, a mesoporous silica nanoparticle called MCM-41 (mobile crystalline material) [42] was developed for the first time as a drug delivery system for the encapsulation of ibuprofen drug [18]. According to the molar composition of the reaction environment, the pores were reported to be hexagonal (MCM-41, 2D or SBA-15), cylindrical (M41S) [43] or cubic (MCM-48, 3D) structure [42,44,45,46].…”

Section: Mesoporous Silica Nanoparticles (Msns)mentioning

confidence: 99%

Mesoporous silica nanoparticles, methods of preparation and use of bone tissue engineering

Kütük

2021

International Journal of Life Sciences and Biotechnology

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Biomaterials are a large group of vitally important materials with many different inorganic and organic types. Biocomposites are produced by using materials such as polymer, metal, and ceramics. Bone tissue engineering deals with materials that can mimic the real bone structure found in the body. These materials used in the human body must be capable of many aspects such as their mechanical strength related to the area where they are used, as well as their properties such as biocompatible, biodegradable, and non-toxic. If the material is intended to treat the bone structure, it should be biodegradable, but it should be resistant to degradation if intended to be used for a long time. With the advance in technology, nanoparticles have become appealing in bone tissue engineering due to their many unique properties. In recent years, mesoporous silica nanoparticles (MSNs) have been prominent biomaterials in the medical field due to their properties such as alterable size structure, large pore volume, and surface area. This study aims to give information about the biomedical properties, synthesis methods, and importance of MSNs with unique properties in bone tissue engineering applications. This study is compiled by examining many studies in the literature.

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“…At present, various composite nanoparticles, such as silica/mesoporous silica nanoparticles, metal-organic matrix nanocomposites, titanium dioxide nanoparticles, polymer nanofilms, and other nanomaterials [7,9,10,11,12,13,14,15,16,17,18,19,20,21], have been used for the loading and release of ibuprofen. Silica/mesoporous silica nanoparticles are non-toxic, biocompatible, biologically inert, and have strong stability even at 1000 °C [10,11,12,13,14]. A large number of hydroxyl groups on their surface can provide connection sites for drug loading to achieve drug delivery.…”

Section: Introductionmentioning

confidence: 99%

Monodisperse Fe3O4/SiO2 and Fe3O4/SiO2/PPy Core-Shell Composite Nanospheres for IBU Loading and Release

Shen

Qiao

et al. 2019

Materials

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The magnetic targeting drug delivery system is an effective way of targeting therapy. In this study, the monodisperse Fe3O4 nanoparticles with a particles size of about 180 nm were first prepared via a solvothermal method. Subsequently, the core-shell structure Fe3O4/SiO2 and Fe3O4/SiO2/polypyrrole (PPy) composite nanospheres were successfully synthesized by coating Fe3O4 nanoparticles with SiO2 shell layer using the Stöber method and PPy shell by solvothermal method in turn. The as-prepared nanoparticles were characterized using transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier transform-infrared spectroscopy (FT-IR), vibrating sample magnetometer (VSM), thermogravimetric analysis (TGA), and Ultraviolet-Visible spectrophotometer (UV-Vis). The results indicated that the as-prepared composite nanospheres displayed a well-defined core-shell structure and monodispersity. The thicknesses of SiO2 shell and PPy shell were ~6 nm and ~19 nm, respectively. Additionally, the as-prepared nanoparticles exhibited high saturation magnetization of 104 emu/g, 77 emu/g, and 24 emu/g, and have great potential applications in drug delivery. The drug loading and drug release of the Fe3O4/SiO2 and Fe3O4/SiO2/PPy composite nanospheres to ibuprofen (IBU) under stirring and ultrasonication were investigated. Their drug loading efficiency and drug release efficiency under ultrasonication were all higher than 33% and 90%, respectively. The drug release analyses showed sustained release of IBU from nanospheres and followed the Korsmeyer-Peppas model.

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Synthesis and characterization of MCM-48/hydroxyapatite composites for drug delivery: Ibuprofen incorporation, location and release studies

Cited by 46 publications

References 43 publications

Synthesis of Chitosan/Diatomite Composite as an Advanced Delivery System for Ibuprofen Drug; Equilibrium Studies and the Release Profile

Synthesis of Chitosan/Diatomite Composite as an Advanced Delivery System for Ibuprofen Drug; Equilibrium Studies and the Release Profile

Mesoporous silica nanoparticles, methods of preparation and use of bone tissue engineering

Monodisperse Fe3O4/SiO2 and Fe3O4/SiO2/PPy Core-Shell Composite Nanospheres for IBU Loading and Release

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