Synthesis and Characterization of Immobilized Lipase on Fe3O4 Nanoparticles as Nano biocatalyst for the Synthesis of Benzothiazepine and Spirobenzothiazine Chroman Derivatives

Abstract

A retrievable nanostructure heterogeneous catalyst, based on lipase (lipase from the fungus Aspergillus niger), namely Fe 3 O 4 -bonded lipase (Fe 3 O 4 NPs@ lipase) was prepared in nano size and fully characterized by several techniques such as Fourier transform infrared spectroscopy, X-ray diffraction, Scanning electron microscopy, Transmission electron microscopy and Vibrating sample magnetometer. The retrievable nanostructure catalyst was asserted to be an efficient catalyst in the synthesis of benzothiazepine and spirobenzothiazine chroman derivatives through three-component reaction of coumarine-3-carboxylic acid derivatives, 2-aminothiophenol, and alkyl isocyanides at room temperature under mild conditions. Graphical Abstract

Synthesis of Lipase-Immobilized CeO2 Nanorods as Heterogeneous Nano-Biocatalyst for Optimized Biodiesel Production from Eruca sativa Seed Oil

“…The comparison of free and immobilized lipase revealed that immobilizing A. terreus Lipase on CeO 2 @PDA increased the flexibility of lipase to a wide pH range, compared to free lipase. Our results were comparable to the studies of Baharfar and Mahajer [13].…”

“…It was found that, by using polydopamine, high immobilization efficiency was achieved by using CeO2 nanorods because polydopamine and CeO2 nanorods formed the complex, which was found to be efficient regarding immobilization of lipase. The wider surface was available during the reaction, which gave higher conversion rate in a short period of time by using the lipase-immobilized nanorods for biodiesel production [13]. To the best of our knowledge, the synthesized nano-…”

Design and characterization of Fe3O4/GO/Au‐Ag nanocomposite as an efficient catalyst for the green synthesis of spirooxindole‐dihydropyridines

“…Considering the above reports and in continuation of our previous studies in the development of the simple and effective multicomponent reactions for the synthesis of novel heterocyclic compounds by heterogeneous catalysts, we wish to report a facile route to fabrication of Fe 3 O 4 /GO/Au‐Ag nanocomposite, which exhibits superior catalytic activity for the efficient preparation of Spiro[indoline‐3,5′‐pyrido[2,3‐ d :6,5‐ d ’]dipyrimidine]‐pentaone derivatives from a wide diversity of isatin, 6‐aminouracil and different 1,3‐dicarbonyl compounds in water under green and mild reaction conditions. Many of methods reported for the synthesis of spirooxindole compounds suffer from disadvantages such as high temperature, use of homogeneous catalyst, long reaction times, and the use of harmful organic solvent .…”

Synthesis and characterization of MgO nanoparticles supported on ionic liquid‐based periodic mesoporous organosilica (MgO@PMO‐IL) as a highly efficient and reusable nanocatalyst for the synthesis of novel spirooxindole‐furan derivatives

“…A plausible mechanism is illustrated in Scheme 3, which is supported by the previous literature. [8,40] To evaluate the recoverability and reusability of MgO@PMO-IL, we used this catalyst in the three- isatin under the optimized conditions. The catalyst was recovered through a simple filtration process and reused for at least seven times without a significant decrease in its catalytic activity ( Figure 5).…”

“…Due to expanding the scope of the IFB reaction, and in continuation of our previous works for the synthesis of novel heterocyclic compounds using heterogeneous catalysts, we have developed a strategy for the preparation of a novel MgO containing PMO‐IL (MgO@PMO‐IL) and examined its application in the Feist–Benary reaction for the synthesis of novel spirooxindole‐furan derivatives via three‐component reaction of isatin derivatives with 1,3‐dicarbonyl compounds and N ‐phenacyl pyridinium salts (Scheme ). The products were synthesized under green reaction conditions with excellent yields, low reaction time and simple work‐up in the presence of a highly efficient and recoverable nanocatalyst …”