Synthesis and characterization of hierarchically macroporous and mesoporous CaO–MO–SiO2–P2O5 (M=Mg, Zn, Sr) bioactive glass scaffolds

Wang, Xiupeng; Li, Xia; Ito, Atsuo; Sogo, Yu

doi:10.1016/j.actbio.2011.06.029

Cited by 131 publications

(84 citation statements)

References 53 publications

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“…In particular our group has been very interested in the last few years in the substitution of MBGs by (i) up to 3.5% Ce2O3, because it was reported that Ce 3+ ions reduce the enamel demineralization, and are neuroprotective [19], (ii) up to 3.5% Ga2O3, because it was published that Ga 3+ ions increase the calcium content in bone, and are antimicrobial [20], and (iii) ZnO because, in addition to other biological functions, it was reported that Zn 2+ ions stimulates the bone formation and exhibit also a bactericide action [21,22]. In the …”

Section: Introductionmentioning

confidence: 99%

Glasses in bone regeneration: A multiscale issue

Salinas

Vallet‐Regí

2016

Journal of Non-Crystalline Solids

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Highligths MBGs containing small amounts of Ga, Ce or Zn exhibit high in vitro bioactivity  The bioactive response is preserved after obtaining 3D scaffolds  These scaffolds are optimum candidates for bone tissue engineering applications  MBG scaffold with 4% ZnO exhibit bactericide action against S. Aureus  The effects of the extra ions is sometimes complex and needs to be investigated 2 Abstract 3D scaffolds based in mesoporous bioactive glasses (MBGs) are being widely investigated to use in bone tissue engineering (TE) applications. These scaffolds are often obtained by rapid prototyping (RP) and exhibit an array of interconnected pores in a hierarchy of sizes. The ordered mesopores network (around 4 nm in diameter), is optimal for the adsorption and release of bone inductor biomolecules, and the arrangement of macropores over 100 m facilitates the bone cell ingrowths and angiogenesis. Nevertheless MBGs composition can be varied almost infinitely at the atomic scale by including in the glass network oxides of inorganic elements with a therapeutic action. In this article the synthesis and characterization of MBG scaffolds based on the 80%SiO2-15%CaO-5%P2O5 (in mol-%) glass with substitutions up to 3.5% of Ga2O3 or Ce2O3 or 7.0% of ZnO is revisited. The substituent inclusion and the RP processing slightly decrease the surface area, the pore volume and the mesoporous order as well as their bioactive response in solutions mimicking blood plasma. However, these values still remain useful for bone TE applications. Results exhibiting the bactericide action of MBG scaffolds containing ZnO are also presented. KeywordsMesoporous bioactive glass scaffolds; Ga, Ce and Zn as therapeutical ions; bactericide capability; bone tissue engineering 3

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Section: Introductionmentioning

confidence: 99%

Glasses in bone regeneration: A multiscale issue

Salinas

Vallet‐Regí

2016

Journal of Non-Crystalline Solids

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“…8,10 Because of their high internal surface area and pore volume, mesoporous nanoparticles are excellent devices for the storage and release of bioactive molecules such as antibacterial reagents and antibiotics. [10][11][12] Recent research indicates that biomaterials containing calcium (Ca) and silicate (Si) elements promote osteogenic differentiation of stem cell in vitro and hard tissue regeneration in vivo. 13,14 In this regard, mesoporous Ca-Si nanoparticles (MCSNs) possess both the merits of mesoporosity and the capability to release Ca and silicic acid ions.…”

Section: Introductionmentioning

confidence: 99%

“…19,20 Thus, many researchers have incorporated antibacterial metal or metal ions into biomaterials, such as mesoporous bioglass or silica nanoparticles, to achieve both antibacterial and pro-osteogenic effects. 12,21,22 Two strategies have been employed for incorporating antibacterial metal or metal ions into biomaterials: adsorption and templating. 12,20,22,23 For mesoporous biomaterials, the adsorption method was most often used for loading antibacterial reagents because of its simplicity.…”

Section: Introductionmentioning

confidence: 99%

“…12,21,22 Two strategies have been employed for incorporating antibacterial metal or metal ions into biomaterials: adsorption and templating. 12,20,22,23 For mesoporous biomaterials, the adsorption method was most often used for loading antibacterial reagents because of its simplicity. 10,23 However, the loading amount of antibacterial metal or metal ions can be more easily controlled by the template method, and the metal or metal ions loaded by the template method are more stable in the carrier material.…”

Section: Introductionmentioning

confidence: 99%

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Effects of adsorbed and templated nanosilver in mesoporous calcium-silicate nanoparticles on inhibition of bacteria colonization of dentin

Fan¹,

Wu²,

Tay³

et al. 2014

IJN

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Mesoporous calcium-silicate nanoparticles (MCSNs) are advanced biomaterials for controlled drug delivery and mineralization induction. Nanosilver-incorporated MCSNs (Ag-MCSNs) were prepared in the present study using both the adsorption and template methods. Both versions of Ag-MCSNs showed characteristic morphology of mesoporous materials and exhibited sustained release of ions over time. In antibacterial testing against planktonic Enterococcus faecalis , Ag-MCSNs showed significantly better antibacterial effects when compared with MCSNs ( P <0.05). The Ag-MCSNs aggregated on the dentin surface of root canal walls and infiltrated into dentinal tubules after ultrasound activation, significantly inhibiting the adherence and colonization of E. faecalis on dentin ( P <0.05). Despite this, Ag-MCSNs with templated nanosilver showed much lower cytotoxicity than Ag-MCSNs with adsorbed nanosilver ( P <0.05). The results of the present study indicated that nanosilver could be incorporated into MCSNs using the template method. The templated nanosilver could release silver ions and inhibit the growth and colonization of E. faecalis both in the planktonic form and as biofilms on dentin surfaces as absorbed nanosilver. Templated Ag-MCSNs may be developed into a new intracanal disinfectant for root canal disinfection due to their antibacterial ability and low cytotoxicity, and as controlled release devices for other bioactive molecules to produce multifunctional biomaterials.

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“…In this sense, several groups have proposed m-BG as components of scaffolds for bone tissue engineering. [7][8][9] Although the existing bioactive inorganic materials (such as BG) possess excellent bioactivity, they are very brittle and have inherently poor tensile properties. 10,11 Polymers such as poly(lactic acid), polyglycolide, and poly(lactide-co-glycolide) have been widely used to fabricate different types of scaffolds for bone repair, owing to their biocompatibility and malleable nature.…”

Section: Introductionmentioning

confidence: 99%

Composite scaffolds of mesoporous bioactive glass and polyamide for bone repair

Cao²,

Yu³

et al. 2012

IJN

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A bone-implanted porous scaffold of mesoporous bioglass/polyamide composite (m-BPC) was fabricated, and its biological properties were investigated. The results indicate that the m-BPC scaffold contained open and interconnected macropores ranging 400-500 µm, and exhibited a porosity of 76%. The attachment ratio of MG-63 cells on m-BPC was higher than polyamide scaffolds at 4 hours, and the cells with normal phenotype extended well when cultured with m-BPC and polyamide scaffolds. When the m-BPC scaffolds were implanted into bone defects of rabbit thighbone, histological evaluation confirmed that the m-BPC scaffolds exhibited excellent biocompatibility and osteoconductivity, and more effective osteogenesis than the polyamide scaffolds in vivo. The results indicate that the m-BPC scaffolds improved the efficiency of new bone regeneration and, thus, have clinical potential for bone repair.

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Synthesis and characterization of hierarchically macroporous and mesoporous CaO–MO–SiO2–P2O5 (M=Mg, Zn, Sr) bioactive glass scaffolds

Cited by 131 publications

References 53 publications

Glasses in bone regeneration: A multiscale issue

Glasses in bone regeneration: A multiscale issue

Effects of adsorbed and templated nanosilver in mesoporous calcium-silicate nanoparticles on inhibition of bacteria colonization of dentin

Composite scaffolds of mesoporous bioactive glass and polyamide for bone repair

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Synthesis and characterization of hierarchically macroporous and mesoporous CaO–MO–SiO2–P2O5 (M=Mg, Zn, Sr) bioactive glass scaffolds

Cited by 131 publications

References 53 publications

Glasses in bone regeneration: A multiscale issue

Glasses in bone regeneration: A multiscale issue

Effects of adsorbed and templated nanosilver in&nbsp;mesoporous calcium-silicate nanoparticles on&nbsp;inhibition of bacteria colonization of dentin

Composite scaffolds of mesoporous bioactive glass and polyamide for bone repair

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Effects of adsorbed and templated nanosilver in mesoporous calcium-silicate nanoparticles on inhibition of bacteria colonization of dentin