Synthesis and characterization of heteroleptic Schiff base transition metal complexes: a study of anticancer, antimicrobial, DNA cleavage and anti-TB activity

New Antimicrobial Strategies Based on Metal Complexes

“…This higher antibacterial activity could be attributed to an enhanced interaction of the complex with DNA. Furthermore, a multitude of Schiff base-copper(II) complexes have been synthesized for their antimicrobial properties [48][49][50][51]. This class of ligands is very interesting in the sense that they are excellent coordinating molecules with strong donor groups (azomethine or imine group) and can exhibit variety in the structure of their metal complexes.…”

Bis(N′-(3-chlorobenzoyl)isonicotinohydrazide)iron(III) Complex

“…To form the complex, the N -(3-chlorobenzoyl)isonicotinohydrazide (2 mmol) and FeCl 3 •6H 2 O (1 mmol) were used. The reflux method was chosen for the reaction to maintain stability so that complex synthesis reactions were successful, even in hot conditions, so that the reactant moles and products were maintained [10,22,23]. The reaction conditions of 75 • C and constant stirring (using a magnetic stirrer) aimed to accelerate and optimize the synthesis reaction process.…”

“…As shown in Figure 5, there is one endothermic peak at 383 • C. The thermogram of TG analysis showed the release of molecules marked by a reduction in mass at a certain temperature. The endothermic peak at 383 • C indicates that the decomposition complex begins with the release of several water molecules [10].…”

“…Isoniazid, also known as isonicotinylhydrazide (INH), is an antibiotic used for the treatment of tuberculosis. It has attracted much attention due to its demonstrated biological activity as an antituberculosis [7][8][9][10][11][12][13][14] and anticancer [15][16][17] agent.…”

Synthesis, Characterization and Evaluate the Biological Activity of Novel Heterocyclic Derivatives from Azomethine Compounds

“…Equimolar mixtures 0.01 mole of aromatic amines and 0.02 mole of aromatic aldehydes dissolved in 25 mL absolute ethanol was placed in a 100 mL round-bottom flask. 3-4 drops of glacial acetic acid was added as catalyst, the mixture was allowed to react at reflux temperature for 4 h and then let to cool down to the room temperature, the progress of the reaction and the purity of the compounds were monitored with TLC technique, whereby a crystalline solid was separated out and recrystallized from ethanol, the structural formula, names, melting points, colors and percentage of yields for the synthesized azomethine compounds R 1 -R 4 are recorded [8][9][10][11][12] .…”