Synthesis and characterization of graphene oxide chitosan aerogels reinforced with flavan-3-ols as hemostatic agents

Figueroa, Toribio; Carmona, Satchary; Guajardo, Sebastián; Borges, Jéssica Ferreira; Aguayo, Claudio; Fernández, Katherina

doi:10.1016/j.colsurfb.2020.111398

Cited by 20 publications

(26 citation statements)

References 47 publications

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“…Moreover, chitosan aerogel prepared by non-acid condition method shows the potential to serve as a wound- healing matrix, exhibits good swelling performance, and is non-toxic [ 101 , 115 ]. Furthermore, graphene oxide and chitosan aerogels reinforced by using a mix of seed and skin extracts from 200 País grapes were developed by Figueroa et al They mentioned that this hybrid aerogel, under alkaline conditions, were not cytotoxic to human dermal fibroblasts [ 116 ]. Borges-Vilches J. et al also did something similar.…”

Section: Biomedical Applications Of Aerogelmentioning

confidence: 99%

Emerging Trends in Nanotechnology: Aerogel-Based Materials for Biomedical Applications

et al. 2023

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At present, aerogel is one of the most interesting materials globally. The network of aerogel consists of pores with nanometer widths, which leads to a variety of functional properties and broad applications. Aerogel is categorized as inorganic, organic, carbon, and biopolymers, and can be modified by the addition of advanced materials and nanofillers. Herein, this review critically discusses the basic preparation of aerogel from the sol–gel reaction with derivation and modification of a standard method to produce various aerogels for diverse functionalities. In addition, the biocompatibility of various types of aerogels were elaborated. Then, biomedical applications of aerogel were focused on this review as a drug delivery carrier, wound healing agent, antioxidant, anti-toxicity, bone regenerative, cartilage tissue activities and in dental fields. The clinical status of aerogel in the biomedical sector is shown to be similarly far from adequate. Moreover, due to their remarkable properties, aerogels are found to be preferably used as tissue scaffolds and drug delivery systems. The advanced studies in areas including self-healing, additive manufacturing (AM) technology, toxicity, and fluorescent-based aerogel are crucially important and are further addressed.

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Section: Biomedical Applications Of Aerogelmentioning

confidence: 99%

Emerging Trends in Nanotechnology: Aerogel-Based Materials for Biomedical Applications

et al. 2023

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“…Using the same rationale of increasing the level of the negative charges at the surface of the material, stable composite aerogels from graphene oxide (GO) and polyvinyl alcohol (PVA), incorporating phenolic extracts from grape were prepared [129,130]. The developed aerogels exhibited the capacity for surface coagulation of whole blood, which was greatly improved by the incorporation and release of polyphenolic extracts with high content of proanthocyanidins, of potential use for wounds due to their wound healing and anti-inflammatory properties.…”

Section: Bioaerogels Application Versus Wound Stagesmentioning

confidence: 99%

Bioaerogels: Promising Nanostructured Materials in Fluid Management, Healing and Regeneration of Wounds

et al. 2021

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Wounds affect one’s quality of life and should be managed on a patient-specific approach, based on the particular healing phase and wound condition. During wound healing, exudate is produced as a natural response towards healing. However, excessive production can be detrimental, representing a challenge for wound management. The design and development of new healing devices and therapeutics with improved performance is a constant demand from the healthcare services. Aerogels can combine high porosity and low density with the adequate fluid interaction and drug loading capacity, to establish hemostasis and promote the healing and regeneration of exudative and chronic wounds. Bio-based aerogels, i.e., those produced from natural polymers, are particularly attractive since they encompass their intrinsic chemical properties and the physical features of their nanostructure. In this work, the emerging research on aerogels for wound treatment is reviewed for the first time. The current scenario and the opportunities provided by aerogels in the form of films, membranes and particles are identified to face current unmet demands in fluid managing and wound healing and regeneration.

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“…A series of chitosan and graphene oxide (CS/GO) aerogels was developed as hemostatic agents by incorporating proanthocyanidins such as flavan-3-ols obtained from grape seed and skin extracts [62]. The aerogels were produced from solutions at two different pHs: acidic and alkaline.…”

Section: Chitosan/graphene Oxide Nanofibersmentioning

confidence: 99%

Chitosan/Graphene Oxide Composite Films and Their Biomedical and Drug Delivery Applications: A Review

et al. 2021

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The healing of wounds is still a challenging clinical problem for which an efficient and fast treatment is needed. Therefore, recent studies have created a new generation of wound dressings that can accelerate the wound healing process with minimal side effects. Chitosan, a natural biopolymer, is an attractive candidate for preparing biocompatible dressings. The biodegradability, non-toxicity, and antibacterial activities of chitosan have made it a promising biopolymer for treating wounds. Graphene oxide has also been considered by researchers as a non-toxic, inexpensive, and biocompatible material for wound healing applications. This review paper discusses the potential use of chitosan/graphene oxide composite films and their application in wound dressing and drug delivery systems.

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Synthesis and characterization of graphene oxide chitosan aerogels reinforced with flavan-3-ols as hemostatic agents

Cited by 20 publications

References 47 publications

Emerging Trends in Nanotechnology: Aerogel-Based Materials for Biomedical Applications

Emerging Trends in Nanotechnology: Aerogel-Based Materials for Biomedical Applications

Bioaerogels: Promising Nanostructured Materials in Fluid Management, Healing and Regeneration of Wounds

Chitosan/Graphene Oxide Composite Films and Their Biomedical and Drug Delivery Applications: A Review

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