Chitosan/Graphene Oxide Composite Films and Their Biomedical and Drug Delivery Applications: A Review

Moradi, Sara; Hamedi, Hamid; Tonelli, Alan E.; King, Martin W.

doi:10.3390/app11177776

Cited by 11 publications

(9 citation statements)

References 77 publications

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“…Nanocomposite wound dressings made from CS-GO have multiple advantages, including adequate mechanical strength, antiinflammatory properties and tissue adhesive characteristics. However, the nanocomposites of CS-GO have limited electron transfer compared to other reported systems [12].…”

Section: Cs-go Nanofibrous Membranesmentioning

confidence: 77%

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A Review on Chitosan-Based Materials as Potential Wound Dressing Materials

Sopyan

HUDAYA²,

Suharyani³

2022

Int J App Pharm

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This review article aimed to study chitosan as a material based in wound dressing preparation. The method in this review is the approximation method. The articles were obtained from national and international journals such as Scopus, PubMed, and Google Scholar by using the keywords "Chitosan", "Wound Healing", and "Biomedical Application". The inclusion criteria of the article are: national and international journals and books contains chitosan as, published in the last ten years, and not review article. The final articles used in this review are 29 articles that studying the use of chitosan as wound dressing material. The combination of chitosan with some polymer, ion and other materials resulting the chitosan-based materials namely nanofibrous membranes, composites sponge, polyelectrolyte complex, and composites, that used in topical preparation such as membranes, fibers, sponge, film, and gel. Thus, the modified of chitosan wound healing preparation resulting in the improve of healing activity of each preparation from. This review summarizes chitosan application in wound healing. Several studies were proposed the porous structure of chitosan-based materials lead the improvement of healing activity.

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Section: Cs-go Nanofibrous Membranesmentioning

confidence: 77%

“…Chitosan encircles a wide range of poly-(beta-1-4) N-acetyl-Dglucosamine materials [12]. Chitosan is a polymer obtained from the deacetylation of chitin.…”

Section: Characterization Of Chitosanmentioning

confidence: 99%

A Review on Chitosan-Based Materials as Potential Wound Dressing Materials

Sopyan

HUDAYA²,

Suharyani³

2022

Int J App Pharm

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“…Khalil et al (2020) also showed that GO-CS and GO-EDTA based nanocomposites display anti-microbial activities against E. coli, S. aureus, and C. albicans. There have been a few pre-clinical investigations on their wound healing applications (Moradi et al 2021). For instance, a temporary skin graft was made of CS-polyvinyl pyrrolidone-GO nanosheets.…”

Section: Antimicrobial Propertiesmentioning

confidence: 99%

Chitosan and graphene oxide-based nanocomposites for water purification and medical applications: A review

Khandegar

Kaur

Chanana

2021

BioRes

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Chitosan (CS) is a natural polysaccharide isolated from insects, molluscs, and fungi. The specific properties of chitosan can be enhanced using physicochemical processes. The composites prepared using CS and graphene oxide (GO) contain active functional groups such as epoxide, carboxyl, and hydroxyl, which possess excellent biocompatibility, high adsorption capacity, and biodegradability. Their low cost and ease of scale-up make them employable for multiple applications in water-treatment plants, electronics, solar cells, and pharmaceuticals. This review provides an overview of sources, types, and properties of chitin, chitosan, and graphene oxide. The use of these composites for the preparation of anti-microbial drugs has been discussed here. The article also explores the applicability of such composites for removal of heavy metals (lead, copper, chromium, cobalt, mercury, etc.), dyes (methylene blue and other reactive dyes), and organic and inorganic contaminants (ofloxacin, naphthanol, phenol, and oil, etc.). The article highlights various knowledge gaps in the field and the scope of future work.

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“…Graphene oxide (GO), one of the important derivatives of graphene, has attracted much attention in recent years. It has been regarded as an effective reinforcement for chitosan films [ 8 ]. Furthermore, PDA-reduced graphene oxide (rGO) was chosen to strengthen chitosan hydrogel with a fast self-healing ability, and attributed to good adhesiveness and enhanced biodegradability [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Shape-Memory-Reduced Graphene/Chitosan Cryogels for Non-Compressible Wounds

Xuan

et al. 2023

IJMS

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In this study, an antibacterial and shape-memory chitosan cryogel with high blood absorption and fast recovery from non-compressible wounds was prepared using a one-step method. Herein, we prepared a shape-memory-reduced graphene/chitosan (rGO-CTS) cryogel using a one-step method with a frozen mixing solution of chitosan, citric acid, dopamine, and graphene oxide, before treating it with alkaline solutions. The alkaline solution not only promoted the double cross-linking of chitosan but also induced dopamine to form polydopamine-reducing graphene oxide. Scanning electron microscope (SEM) images showed that the rGO-CTS cryogel possessed a uniform porous network structure, attributing excellent water-induced shape-memory properties. Moreover, the rGO-CTS cryogel exhibited good mechanical properties, antibacterial activity, and biocompatibility. In mouse liver trauma models, the rGO-CTS cryogel showed good blood clotting and hemostatic capabilities. Therefore, this composite cryogel has great potential as a new hemostatic material for application to non-compressible wounds.

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Chitosan/Graphene Oxide Composite Films and Their Biomedical and Drug Delivery Applications: A Review

Cited by 11 publications

References 77 publications

A Review on Chitosan-Based Materials as Potential Wound Dressing Materials

A Review on Chitosan-Based Materials as Potential Wound Dressing Materials

Chitosan and graphene oxide-based nanocomposites for water purification and medical applications: A review

Shape-Memory-Reduced Graphene/Chitosan Cryogels for Non-Compressible Wounds

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