Synthesis and characterization of gold nanoparticles combined with curcumin and its effect on experimental osteoarthritis in mice

Campos, Wilma N. S.; Marangoni, Valéria S.; Sônego, Dábila Araújo; Andrade, Mateus Annicchino de; Colodel, E.M.; Souza, Roberto Lopes de

doi:10.1016/j.joca.2015.02.732

Cited by 5 publications

(3 citation statements)

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“…Gold colloid or gold salts can exert anti-inflammation effect by downregulating the expression of interleukin-1β, prostaglandin E2, and cyclooxygenase-2 [ 12 – 15 ], which plays a crucial role in the pathogenesis of OA [ 16 – 21 ]. Recently, it was reported that mice model of OA, after treatment with gold nanoparticles (AuNPs) combined with curcumin, presented less severe in the histological lesions [ 22 ]. Similarly, AuNPs (7–130 nm) capped with different drugs exhibited potential treatment for OA [ 23 – 25 ].…”

Section: Introductionmentioning

confidence: 99%

Gold Nanoparticles of Diameter 13 nm Induce Apoptosis in Rabbit Articular Chondrocytes

et al. 2016

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Gold nanoparticles (AuNPs) have been widely used in biomedical science including antiarthritic agents, drug loading, and photothermal therapy. In this report, we studied the effects of AuNPs with diameters of 3, 13, and 45 nm, respectively, on rabbit articular chondrocytes. AuNPs were capped with citrate and their diameter and zeta potential were measured by dynamic light scattering (DLS). Cell viability was evaluated by Cell Counting Kit-8 (CCK-8) assay after the rabbit articular chondrocytes were pre-incubated with 3, 13, and 45 nm AuNPs, respectively, for 24 h. Flow cytometry (FCM) analysis with annexin V/propidium iodide (PI) double staining and fluorescence imaging with Hoechst 33258 staining were used to determine the fashion of AuNPs-induced chondrocyte death. Further, 13 nm AuNPs (2 nM) significantly induced chondrocyte death accompanying apoptotic characteristics including mitochondrial damage, externalization of phosphatidylserine and nuclear concentration. However, 3 nm AuNPs (2 nM) and 45 nm (0.02 nM) AuNPs did not induce cytotoxicity in chondrocytes. Although 13 nm AuNPs (2 nM) increased the intracellular reactive oxygen species (ROS) level, pretreatment with Nacetyl cysteine (NAC), a ROS scavenger, did not prevent the cytotoxicity induced by 13 nm AuNPs, indicating that 13 nm AuNPs (2 nM) induced ROS-independent apoptosis in chondrocytes. These results demonstrate the size-dependent cytotoxicity of AuNPs in chondrocytes, which must be seriously considered when using AuNPs for treatment of osteoarthritis (OA).

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Section: Introductionmentioning

confidence: 99%

Gold Nanoparticles of Diameter 13 nm Induce Apoptosis in Rabbit Articular Chondrocytes

et al. 2016

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“…Fortunately, AuNP-based medicine emerged, which is less toxic and more efficient. Indeed, AuNPs have shown excellent efficacy in arthritis treatment by inhibiting inflammatory response, both as a carrier and as a therapeutic agent, as demonstrated by various studies [ [56] , [57] , [58] , [59] ]. However, the report about the protective effect of AuNPs on cartilage, especially GP cartilage, as a response to inflammation in children is limited.…”

Section: Discussionmentioning

confidence: 99%

Chondrocyte targeting gold nanoparticles protect growth plate against inflammatory damage by maintaining cartilage balance

Bai,

Sun,

Jia

et al. 2023

Materials Today Bio

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“…Fortunately, AuNP-based medicine emerged, which is less toxic and more e cient. Indeed, AuNPs have shown excellent e cacy in arthritis treatment by inhibiting in ammatory response, both as a carrier and as a therapeutic agent, as demonstrated by various studies [57][58][59][60]. However, the report about the protective effect of AuNPs on cartilage, especially GP cartilage, as a response to in ammation in children is limited.…”

Section: Discussionmentioning

confidence: 99%

Chondrocyte Targeting Gold Nanoparticles Protect Growth Plate Against Inflammatory Damage By Maintaining Cartilage Balance

Bai

Sun

Jia

et al. 2021

Preprint

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Background: Cartilage destruction caused by inflammation is a clinical challenge. Many studies have investigated cartilage destruction in adults, but little research was conducted on children. Results: The gaps without chondrocytes and ECM between the proliferative and hypertrophy zones of the GP cartilage were formation after the treatment of LPS, but the gaps were not observed in the AuNPs + LPS group. This finding can be attributed to the capability of AuNPs to target to the chondrocytes and reduce the release of inflammatory cytokines and secretion of ECM degradation factors induced by LPS. And then, the LPS-induced apoptosis rate of mouse chondrocytes and ECM degradation rate were inhibited. Finally, the balance of catabolic and anabolic factors in the ECM was maintained.Conclusion: These findings indicate that AuNPs can partially protect the cartilage of children from inflammatory damage by suppressing chondrocyte apoptosis and ECM degradation.

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Synthesis and characterization of gold nanoparticles combined with curcumin and its effect on experimental osteoarthritis in mice

Abstract: Purpose: There is a high prevalence of osteoarthritis(OA) in old population, and physicans usually treat OA based on the guideline recommended by OARSI. Until now, there is no report about the treatment in Abstracts / Osteoarthritis and Cartilage 23 (2015) A82eA416 A397

Cited by 5 publications

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Gold Nanoparticles of Diameter 13 nm Induce Apoptosis in Rabbit Articular Chondrocytes

Gold Nanoparticles of Diameter 13 nm Induce Apoptosis in Rabbit Articular Chondrocytes

Chondrocyte targeting gold nanoparticles protect growth plate against inflammatory damage by maintaining cartilage balance

Chondrocyte Targeting Gold Nanoparticles Protect Growth Plate Against Inflammatory Damage By Maintaining Cartilage Balance

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