Chondrocyte targeting gold nanoparticles protect growth plate against inflammatory damage by maintaining cartilage balance

Bai, Xue; Sun, Hongyan; Jia, Lina; Xu, Junjie; Zhang, Peng; Zhang, Deyuan; Gu, Yu; Chen, Bo; Feng, Lin

doi:10.1016/j.mtbio.2023.100795

Cited by 5 publications

(2 citation statements)

References 68 publications

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“…Owing to the capability of binding vascular endothelial growth factor (VEGF) and eliminating reactive oxygen species (ROS) that are associated with the onset and progression of joint diseases, AuNPs are known as a promising drug vehicle for the treatment of RA . Bai et al found that AuNPs reduced chondrocyte apoptosis and ECM degradation, efficiently protecting children’s cartilage from inflammatory damage . In addition, due to their properties such as surface plasmon resonance and strong optical absorption, AuNPs are extensively applied for the diagnosis of degenerative joint diseases.…”

Section: Nano Delivery Systems For Cartilage Repairmentioning

confidence: 99%

“…68 Bai et al found that AuNPs reduced chondrocyte apoptosis and ECM degradation, efficiently protecting children's cartilage from inflammatory damage. 69 In addition, due to their properties such as surface plasmon resonance and strong optical absorption, AuNPs are extensively applied for the diagnosis of degenerative joint diseases. By modifying with metalloproteinase-targeting peptide, AuNPs were able to detect the activity of metalloproteinase in human synovial fluid.…”

Section: Nano Delivery Systems For Cartilage Repairmentioning

confidence: 99%

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Harnessing Nanomedicine for Cartilage Repair: Design Considerations and Recent Advances in Biomaterials

Zhou,

Zhang,

et al. 2024

ACS Nano

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Cartilage injuries are escalating worldwide, particularly in aging society. Given its limited self-healing ability, the repair and regeneration of damaged articular cartilage remain formidable challenges. To address this issue, nanomaterials are leveraged to achieve desirable repair outcomes by enhancing mechanical properties, optimizing drug loading and bioavailability, enabling site-specific and targeted delivery, and orchestrating cell activities at the nanoscale. This review presents a comprehensive survey of recent research in nanomedicine for cartilage repair, with a primary focus on biomaterial design considerations and recent advances. The review commences with an introductory overview of the intricate cartilage microenvironment and further delves into key biomaterial design parameters crucial for treating cartilage damage, including microstructure, surface charge, and active targeting. The focal point of this review lies in recent advances in nano drug delivery systems and nanotechnology-enabled 3D matrices for cartilage repair. We discuss the compositions and properties of these nanomaterials and elucidate how these materials impact the regeneration of damaged cartilage. This review underscores the pivotal role of nanotechnology in improving the efficacy of biomaterials utilized for the treatment of cartilage damage.

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Section: Nano Delivery Systems For Cartilage Repairmentioning

confidence: 99%

Section: Nano Delivery Systems For Cartilage Repairmentioning

confidence: 99%

Harnessing Nanomedicine for Cartilage Repair: Design Considerations and Recent Advances in Biomaterials

Zhou,

Zhang,

et al. 2024

ACS Nano

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Electroactive Biomaterials Regulate the Electrophysiological Microenvironment to Promote Bone and Cartilage Tissue Regeneration

Chen,

Yang,

Cai

et al. 2024

Adv Funct Materials

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The incidence of large bone and articular cartilage defects caused by traumatic injury is increasing worldwide; the tissue regeneration process for these injuries is lengthy due to limited self‐healing ability. Endogenous bioelectrical phenomenon has been well recognized to play an important role in bone and cartilage homeostasis and regeneration. Studies have reported that electrical stimulation (ES) can effectively regulate various biological processes and holds promise as an external intervention to enhance the synthesis of the extracellular matrix, thereby accelerating the process of bone and cartilage regeneration. Hence, electroactive biomaterials have been considered a biomimetic approach to ensure functional recovery by integrating various physiological signals, including electrical, biochemical, and mechanical signals. This review will discuss the role of endogenous bioelectricity in bone and cartilage tissue, as well as the effects of ES on cellular behaviors. Then, recent advances in electroactive materials and their applications in bone and cartilage tissue regeneration are systematically overviewed, with a focus on their advantages and disadvantages as tissue repair materials and performances in the modulation of cell fate. Finally, the significance of mimicking the electrophysiological microenvironment of target tissue is emphasized and future development challenges of electroactive biomaterials for bone and cartilage repair strategies are proposed.

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Dynamic Proteinaceous Hydrogel Enables In‐Situ Recruitment of Endogenous TGF‐β1 and Stem Cells for Cartilage Regeneration

Guo,

Yin,

Wang

et al. 2024

Adv Funct Materials

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Articular cartilage is a tissue with relatively poor self‐regeneration capacity due to insufficient blood vessels and chondrocytes in the region. Biomaterial‐assisted tissue engineering has shown great potential in cartilage regeneration. However, there are still many worries over the uses of exogenous growth factors, stem cells and scaffolds. To address these concerns, here a dynamic proteinaceous hydrogel with a self‐recruiting ability of cartilage‐inducing factor for in situ cartilage regeneration is reported. The dynamic hydrogel (Pep‐GelSH) is prepared by using thiol‐modified gelatin and thiol‐capped TGF‐β1‐affinity peptide through the Au‐S coordination. The injectability and self‐recovery of Pep‐GelSH hydrogel enabled not only minimally invasive implantation but also the adaptability of the scaffold to irregular defect shapes. Meanwhile, the dynamic hydrogel showed improved adherence to the host tissue and allowed quick infiltration of host cells. More importantly, the hydrogel significantly enhanced local enrichment of endogenous TGF‐β1 and led to the recruitment of stem cells in vivo. After implantation, the hydrogel scaffold triggered the innate repair capacity of cartilage defects by successively promoting stem cells recruitment, infiltration and differentiation, resulting in significantly enhanced chondrogenesis and improved cartilage repair. Therefore, the study in this work may provide a feasible and promising approach for in situ cartilage regeneration.

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Chondrocyte targeting gold nanoparticles protect growth plate against inflammatory damage by maintaining cartilage balance

Cited by 5 publications

References 68 publications

Harnessing Nanomedicine for Cartilage Repair: Design Considerations and Recent Advances in Biomaterials

Harnessing Nanomedicine for Cartilage Repair: Design Considerations and Recent Advances in Biomaterials

Electroactive Biomaterials Regulate the Electrophysiological Microenvironment to Promote Bone and Cartilage Tissue Regeneration

Dynamic Proteinaceous Hydrogel Enables In‐Situ Recruitment of Endogenous TGF‐β1 and Stem Cells for Cartilage Regeneration

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