Synthesis and Characterization of Few New Substituted 1,3,4-Oxadiazoles 1,2,4-Triazoles and Schiff Bases via Chalcone Compounds

Ahmed, Amena A.; Mahmood, Intisar Q.; Aziz, Hadil S.

doi:10.25258/ijddt.12.3.27

Cited by 3 publications

(2 citation statements)

References 15 publications

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“…These tests produced data on both the physical and spectral properties of the compounds. In order to validate the structure of the compounds, several experiments were carried out 19 .…”

Section: From Chalconesmentioning

confidence: 99%

Occurrence, Chemistry and Synthesis of Various Novel Methods of Oxadiazole

-¹

2023

IJFMR

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Oxadiazoles are a kind of heterocyclic molecule that can be identified by their five-membered ring structure, two azo groups, and a single oxygen atom in their make-up. These characteristics allow them to be distinguished from other heterocyclic compounds. Because of these features, it is possible to differentiate them from several other heterocyclic compounds. They have the highest importance and relevance in the area of heterocyclic chemistry, which is also where they have the most value. They are of the biggest significance. Research is being conducted on it in substantial amounts due to the fact that it has the potential to function as a starting point for the synthesis of bioactive molecules that are beneficial to the body. This article provides a brief discussion of the physicochemical features of oxadiazole, including its spectra and a few examples of how it may be synthesised. The article can be found here. The pharmacological effects of oxadiazole derivatives were investigated by our team of researchers, and the findings indicated that these compounds had a number of positive benefits, including anti-inflammatory, anti-cancer, anti-fungal, anti-osteoporotic, and anti-microbial properties. In this piece, we will have a brief discussion on both synthetic and naturally occurring medications that include the oxadiazole ring in addition to the moiety. This talk will focus on pharmaceuticals that have been manufactured. The production of these compounds may take place in a laboratory, or they may be found occurring naturally in their natural environments.

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“…These tests produced data on both the physical and spectral properties of the compounds. In order to validate the structure of the compounds, several experiments were carried out 19 .…”

Section: From Chalconesmentioning

confidence: 99%

Occurrence, Chemistry and Synthesis of Various Novel Methods of Oxadiazole

-¹

2023

IJFMR

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“…These compounds were found to possess various pharmacological activities such as anticancer, antimicrobial, anti-inflammatory, anticonvulsant, antimalarial, antischistosomal and antitubercular activities. The Schiff base derivatives like 2,4dinitrophenylhydrazone derivatives-based Schiff bases exhibited potential DNA-damaging action and acts as mutagenic agents with better optical properties 5,6 .…”

Section: Introductionmentioning

confidence: 99%

A Review on Chemistry, Synthesis and Biological Applications of Chalcone-based Schiff Bases

Sekar

Kumar

Raju

2023

J. Drug Delivery Ther.

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Heterocyclic compounds are an important class of compounds in the field of pharmaceutical and synthetic organic chemistry. The Schiff bases contain azomethine linkages which are obtained by the condensation of aldehyde/ketone with amines. Among the various types of Schiff bases, the chalcone-based Schiff bases play a vital role in the treatment of various ailments and various applications, which can be synthesized by using different types of chalcones as the starting materials. These types of compounds were synthesized by using various techniques like conventional means of synthesis, microwave-assisted reaction, heterocyclic catalyst-mediated synthesis and also by means of trituration. The chalcone or bis-chalcone-based Schiff bases and their derivatives contain -C=N linkage which exhibits various activities including antimicrobial, anticancer, antioxidant, antidiabetic and immunosuppressant activities. Beyond these activities, these types of Schiff bases are also used in various chemical industries and fluorescent sensors, which also play a major role in the field of synthetic organic chemistry and coordination chemistry as intermediates. This review discusses the numerous synthetic strategies along with their applications in the field of medicine. Thus, this review will be helpful in developing more effective drug-like scaffolds for use in future drug design. Keywords: Schiff bases, Chalcone-based Schiff bases, Antimicrobial, Anticancer, Antioxidant, Biological Applications

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Synthesis of Some New 1,3,4-Thiadiazole Derivatives Derived from Cholic Acid and Evaluation of their Biological Activity

Alaraj,

Saeed,

Reyadh

et al. 2024

Journal of the Turkish Chemical Society Section A: Chemistry

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In this work, several oxadiazole, thiadiazole, and triazole derivatives, as well as new Schiff bases, were prepared. Cholic acid was used as a starting material to prepare the five-membered heterocyclic compounds. The synthesized compounds were identified by FTIR and 1H,13C-NMR spectroscopy, which elucidated and confirmed the structure of the target molecules. Estimation of the biological activity of the newly produced compounds has been conducted against two types of Gram-positive and Gram-negative pathogenic bacteria.

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Synthesis and Characterization of Few New Substituted 1,3,4-Oxadiazoles 1,2,4-Triazoles and Schiff Bases via Chalcone Compounds

Cited by 3 publications

References 15 publications

Occurrence, Chemistry and Synthesis of Various Novel Methods of Oxadiazole

Occurrence, Chemistry and Synthesis of Various Novel Methods of Oxadiazole

A Review on Chemistry, Synthesis and Biological Applications of Chalcone-based Schiff Bases

Synthesis of Some New 1,3,4-Thiadiazole Derivatives Derived from Cholic Acid and Evaluation of their Biological Activity

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