Synthesis and characterization of ferrocenyl camphor compounds

Ferreira, Ana Sofia; Schulz, Jiří; Galvão, Adelino M.; Roseiro, Alexandra P. S.; Štěpnička, Petr; Veiros, Luı́s F.; Carvalho, M. Fernanda N. N.

doi:10.1016/j.jorganchem.2013.11.039

Cited by 7 publications

(4 citation statements)

References 37 publications

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“…3 L differs from 1 L and 2 L in an extra ring annulated to the camphor skeleton. Camphor sulphonylimines can coordinate transition metals through the hydrazone (Fe(II)) 38 or the sulphonylimine (Pd(II)) 35 groups. In what concerns coordination to silver the SO 2 group of camphorsulfonic acid 39 is also feasible.…”

Section: Dalton Transactions Papermentioning

confidence: 99%

Antibacterial activity of silver camphorimine coordination polymers

et al. 2016

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Five new silver camphorimine complexes of general formula [Ag(NO3)(Y)L] were synthesized and fully characterized using spectroscopic and analytical techniques. The structure of [Ag(NO3)(OC10H14NC6H4NC10H14O)] () was analyzed using single crystal X-ray diffraction, showing that it arranges as a coordination polymer formed by sequential Ag(NO3) units bridged by the bi-camphor ligand (). The antimicrobial properties of the new complexes were screened using the disk diffusion method and their Minimal Inhibitory Concentrations (MIC) were assessed against selected bacterial strains of the Gram-positive Staphylococcus aureus and the Gram-negative Escherichia coli, Pseudomonas aeruginosa, and Burkholderia contaminans. The lowest MICs were observed for , with estimated values of 72, 20, 32 and 19 μg mL(-1) for S. aureus, E. coli, B. contaminans, and P. aeruginosa, respectively. In the case of S. aureus, similar MIC values were obtained for silver nitrate and compound . All five compounds were bactericidal when used in concentrations equal or above the MIC value, as found by enumerating the total colony forming units (CFUs) after incubation in their presence.

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Section: Dalton Transactions Papermentioning

confidence: 99%

Antibacterial activity of silver camphorimine coordination polymers

et al. 2016

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“…51 Compound 1 was prepared from camphor (Aldrich) following the procedure in ref. 52. The solvents ( p.a.…”

Section: Methodsmentioning

confidence: 99%

Oxygen activation by copper camphor complexes

Roseiro

Adão

Galvão

et al. 2015

Inorg. Chem. Front.

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“…CO 2 was purchased from Air Liquid. Camphorsulphonyl chloride (CS-Cl) was purchased from Fluka and the camphor compounds CCA-H, CCA-Li, 39 isonitrosocamphor (CI-OH) 40 and 3-oxocamphor-sulfonimide (CSI) 41,42 were prepared according to published procedures.…”

Section: Synthesis Of Camphor Compoundsmentioning

confidence: 99%

“…7) were purchased (CSI) or synthesized according to published procedures (see below). [39][40][41][42] The synthesized compounds are paradigms of the ligands tested in the docking studies: CC-NLi represents scaffolds 7 and 10, CSI corresponds to scaffold 4 with R 1 ¼ R 2 ¼ H, CI-OH corresponds to scaffold 1 with R 1 ¼ R 2 ¼ H, CC-NH is the nonlithiated version of CC-NLi, and C-phenaz represents scaffolds 8 and 9, which are two of the scaffolds with a higher correlation to a stronger binding ability. Besides these, CCA-H, the precursor of the synthetic pathways used, and CS-Cl, a simpler analogue of scaffold 4, were also tested.…”

Section: Synthetic Approachmentioning

confidence: 99%

Camphor-based CCR5 blocker lead compounds – a computational and experimental approach

et al. 2016

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The C-C chemokine receptor type 5 (CCR5) is a transmembrane receptor that plays a pivotal role as a HIV anchor to human cell membranes, mediating viral entry. CCR5 antagonists, acting by blocking the receptor and preventing its interaction with the HIV proteins, are key agents towards effective anti-viral therapy. This work describes the computational study, synthesis and viral inhibition assay of a number of camphor derivatives as a first step towards new drug leads to block this specific entry pathway. Viral inhibition assays have identified three molecules, camphor carboxylic acid, its tri(hydroxymethyl)aminomethane amide derivative, and an hydroxyl-imide camphor derivative as promising agents to develop new drugs, with IC 50 values (0.16, 0.22 and 1.02 mM, respectively) one order below that of maraviroc (0.02 mM), a clinically used CCR5 antagonist.

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Synthesis and characterization of ferrocenyl camphor compounds

Cited by 7 publications

References 37 publications

Antibacterial activity of silver camphorimine coordination polymers

Antibacterial activity of silver camphorimine coordination polymers

Oxygen activation by copper camphor complexes

Camphor-based CCR5 blocker lead compounds – a computational and experimental approach

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