Synthesis and Characterization of Fe(III) Complex with N’- (3-Nitrobenzoyl)Isonicotinohydrazide as an Anti-tuberculosis Candidate

Abstract

Recently, we have been conducted synthesis of complex compounds of Fe(III)N’-(3- nitrobenzoyl)isonicotinohydrazideusing refluxing N’-(3 -nitrobenzoyl)isonicotinohydrazideas ligands and FeCl3.6H2O as the metal at 75 °C for 6 hours in ethanol. The synthesis results obtained82.45% recovery, and from the purity test are shown with a narrow melting range is 220-222°C. Based on identification with UV-Visible spectrophotometer, infrared spectrometer and Atomic Absorption Spectrophotometer (AAS) indicate that the complex compound have λmax of 272.00 nm, giving vibration of Fe-O at 495.1 cm−1 and 599.6 cm−1 with formula complex compounds, namely [Fe(C13H10N4O4(H2O)4)Cl3].10 H2O.

Bis(N′-(3-chlorobenzoyl)isonicotinohydrazide)iron(III) Complex

“…MS spectra were recorded by high-resolution mass spectrometry (Waters Corp., Milford, MA, USA). Thermogravimetric analysis was performed using a STA 449 F1 Jupiter analyzer (NETZSCH, Selb, Germany) [27]. As shown in Figure 5, there is one endothermic peak at 383 • C. The thermogram of TG analysis showed the release of molecules marked by a reduction in mass at a certain temperature.…”

“…MS spectra were recorded by high-resolution mass spectrometry (Waters Corp., Milford, MA, USA). Thermogravimetric analysis was performed using a STA 449 F1 Jupiter analyzer (NETZSCH, Selb, Germany) [27].…”

Synthesis and virtual screening of bis-(4-(tert-butyl)-N-(methylcarbamothioyl) benzamide)-Iron (III) complex as an anticancer candidate

“…DMSO with a concentration of 100 ppm and 200 ppm, is used to dematerialize standards and samples. Then used the electronic spectrum from a UV-Vis spectrophotometer to measure it in the 200 nm -800 nm area, and the absorbance was observed based on the maximum wavelength (Ruswanto et al, 2019).…”

“…The 4-(tert-butyl)-N-(methylcarbamothioyl) benzamide is a compound derived from 1-benzoyl-3-methylthiourea (Ruswanto et al, 2018). One of the many advances to drug production is to convert compounds into metal complexes, making their absorption and distribution and their pharmacological activities better (Lin et al, 2008;Mardianingrum et al, 2019;Ruswanto et al, 2019).…”