Synthesis and characterization of dual responsive sodium alginate-g-acryloyl phenylalanine-poly N -isopropyl acrylamide smart hydrogels for the controlled release of anticancer drug

Jalababu, R.; Veni, S. Satya; Reddy, K.T. Ramakrishna

doi:10.1016/j.jddst.2017.12.013

Cited by 43 publications

(12 citation statements)

References 58 publications

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“…PNIPAM hydrogel is a promising material for drug delivery that can encapsulate drugs easily and give a temperature-dependent drug release in a slow and linear profile [9,[87][88][89]. Recently, PNIPAM-based composite hydrogels have been developed for applications of controlled drug delivery systems, which can overcome the drawbacks of the conventional drug delivery systems by enhancing drug solubility, sustained release time and reducing side effects [14,90,91].…”

Section: Pnipam-based Composite Hydrogels For Drug Deliverymentioning

confidence: 99%

Poly(N-isopropylacrylamide)-Based Thermoresponsive Composite Hydrogels for Biomedical Applications

Liu

Fu³

et al. 2020

Polymers

244

146

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Poly(N-isopropylacrylamide) (PNIPAM)-based thermosensitive hydrogels demonstrate great potential in biomedical applications. However, they have inherent drawbacks such as low mechanical strength, limited drug loading capacity and low biodegradability. Formulating PNIPAM with other functional components to form composited hydrogels is an effective strategy to make up for these deficiencies, which can greatly benefit their practical applications. This review seeks to provide a comprehensive observation about the PNIPAM-based composite hydrogels for biomedical applications so as to guide related research. It covers the general principles from the materials choice to the hybridization strategies as well as the performance improvement by focusing on several application areas including drug delivery, tissue engineering and wound dressing. The most effective strategies include incorporation of functional inorganic nanoparticles or self-assembled structures to give composite hydrogels and linking PNIPAM with other polymer blocks of unique properties to produce copolymeric hydrogels, which can improve the properties of the hydrogels by enhancing the mechanical strength, giving higher biocompatibility and biodegradability, introducing multi-stimuli responsibility, enabling higher drug loading capacity as well as controlled release. These aspects will be of great help for promoting the development of PNIPAM-based composite materials for biomedical applications.

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Section: Pnipam-based Composite Hydrogels For Drug Deliverymentioning

confidence: 99%

Poly(N-isopropylacrylamide)-Based Thermoresponsive Composite Hydrogels for Biomedical Applications

Liu

Fu³

et al. 2020

Polymers

244

146

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“…Water swelling of the CIPA series at 60°C is not notably changed compared with that at 40°C. Poly(IPA) is known to swell in aqueous solution below LCST but shrinks above LCST to show temperature‐sensitive transformation . The transformation of grafted poly(IPA) at 40°C slightly increases water swelling of PU in proportion to IPA content in the IPA series (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Smart polymers have potential applications in smart fabrics that respond to body temperature and humidity , biomedical fields (such as drug delivery systems) , artificial muscles actuated by electric signals , and self‐healing materials for automotive bumpers and side panels . As a temperature‐sensitive smart polymer, poly(N‐isopropylacrylamide; poly[IPA]) has been studied for delivery of anticancer drugs and hydrophobic drugs in biomedical fields because the lower critical solution temperature (LCST) of poly(IPA; 32°C) is close to body temperature, and can transform itself at the approximate LCST. In addition, poly(IPA) can swell in aqueous solution below LCST but shrinks above LCST to release encapsulated drugs.…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of hydrophilic temperature‐dependent polyurethane containing the grafted poly(N‐isopropylacrylamide)

Chung

Bae

Choi

et al. 2019

Polymer Engineering & Sci

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The polyurethane (PU) structure is modified with dimethylolpropionic acid (DMPA) and poly(N‐isopropylacrylamide; poly[IPA]) to prepare hydrophilic temperature‐dependent PU that is investigated with reference to the degree of crosslinking, thermal properties of soft segment, tensile and shape memory performance, hydrophilic conversion of surface, and temperature‐dependent water swelling and water vapor permeability (WVP). The thermal properties of soft segment (melting, crystallization, and glass transition) are significantly affected by poly(IPA). Breaking tensile stress also increases with increasing IPA monomer content due to crosslinking effect but breaking tensile strain does not significantly decrease with increasing IPA monomer content. Shape recovery capability at 10°C steeply inclines to over 90% from 46.9% for unmodified PU by the grafting of poly(IPA), whereas shape retention at −25°C does not decrease below 90% with the increase in IPA content. Poly(IPA)‐grafted PU can display temperature‐dependent control of water swelling and WVP due to transformation of the grafted poly(IPA) depending on the surrounding temperature. POLYM. ENG. SCI., 59:1719–1728 2019. © 2019 Society of Plastics Engineers

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“…Biopolymers are used as nano-and microparticles (for oral and intravenous insertion) and bulky hydrogel matrices (cryogels if the matrix is formed at low temperatures) with controlled drug release for local application [9,10]. The systems based on chitosan, gelatin, and calcium alginate could be also used as possible biopolymer depots for drug substances with their elongated and controlled release [11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Metal Nanoparticle Containing Nanocomposites of Drug Substances and Their Potential Biomedical Applications

et al. 2019

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New hybrid nanosystems containing the antibacterial substances dioxidine or gentamicin sulfate with bioactive metal (Ag, Cu) nanoparticles have been obtained by a cryogenic freeze-drying method and incorporate further the nanocomposites thus obtained into the cryogenically structured biopolymeric matrices based on gelatin, calcium alginate, and chitosan. FTIR, UV-visible, and NMR spectroscopy, TEM and SEM microscopy data show that the resulting systems consist of wide-porous polymer sponges (pore diameters, 10–200 μm) that contain antibacterial drugs and silver (2–30 nm) or copper (1–5 nm) nanoparticles. The investigation showed that these systems ensure a gradual release of dioxidine (from 40 min up to 3 days), depending on the nature of the matrix and its microstructure. The higher activity of hybrid composites based on nanometals and dioxidine or incorporated into cryostructured biopolymer matrices against the bacterial strains of Escherichia coli 52, Staphylococcus aureus 144 is demonstrated as compared to the individual components in the same matrices.

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Synthesis and characterization of dual responsive sodium alginate-g-acryloyl phenylalanine-poly N -isopropyl acrylamide smart hydrogels for the controlled release of anticancer drug

Cited by 43 publications

References 58 publications

Poly(N-isopropylacrylamide)-Based Thermoresponsive Composite Hydrogels for Biomedical Applications

Poly(N-isopropylacrylamide)-Based Thermoresponsive Composite Hydrogels for Biomedical Applications

Preparation and characterization of hydrophilic temperature‐dependent polyurethane containing the grafted poly(N‐isopropylacrylamide)

Metal Nanoparticle Containing Nanocomposites of Drug Substances and Their Potential Biomedical Applications

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