Metal Nanoparticle Containing Nanocomposites of Drug Substances and Their Potential Biomedical Applications

Abstract

New hybrid nanosystems containing the antibacterial substances dioxidine or gentamicin sulfate with bioactive metal (Ag, Cu) nanoparticles have been obtained by a cryogenic freeze-drying method and incorporate further the nanocomposites thus obtained into the cryogenically structured biopolymeric matrices based on gelatin, calcium alginate, and chitosan. FTIR, UV-visible, and NMR spectroscopy, TEM and SEM microscopy data show that the resulting systems consist of wide-porous polymer sponges (pore diameters, 10–200 μm) that contain antibacterial drugs and silver (2–30 nm) or copper (1–5 nm) nanoparticles. The investigation showed that these systems ensure a gradual release of dioxidine (from 40 min up to 3 days), depending on the nature of the matrix and its microstructure. The higher activity of hybrid composites based on nanometals and dioxidine or incorporated into cryostructured biopolymer matrices against the bacterial strains of Escherichia coli 52, Staphylococcus aureus 144 is demonstrated as compared to the individual components in the same matrices.

The emergence of nanocarriers in the management of diseases and disorders

“…Contact aided distribution mixes nanodroplet phospholipid membranes into target cell membranes, releasing their payload directly into the cytoplasm. [23][24][25][26] The Table 3 shows some of the reported researches and reviews on ultrasound mediated nanocarriers. [16][17][18][19][20]…”

“…[47][48][49][50] The Table 5 shows some of the reported researches and reviews on nanocomposites. [26][27][28][29] Protein nanocarriers Proteins are natural molecules with specific biological and manufacturing features. Nanomaterials from protein, albumin, and gelatin.…”

“…No. Author Year Encapsulated material Formulation Description/Applications 1 Shabatina et al [26] 2020 Antibacterial substances dioxidine or gentamicin sulphate Nanocomposites Cu/dioxidine nanocomposites 2 Sharma et al [27] 2018 Ondansetron Nanocomposites Controlled drug delivery 3 Ghaderi-Ghahfarrokhi et al [28] 2018 Diphenhydramine hydrochloride and diclofenac sodium Nanocomposites Modified halloysite nanotubes of targeted delivery 4…”

Cryostructuring of Polymeric Systems. 55. Retrospective View on the More than 40 Years of Studies Performed in the A.N.Nesmeyanov Institute of Organoelement Compounds with Respect of the Cryostructuring Processes in Polymeric Systems

“…Beyond these variants, in the case of the sponge-like cryogenically-structured matrices that possess the system of a capillary size (cross-section of tens and hundreds microns) interconnected wide pores, there is the possibility to soak the polymeric carrier with some suspensions of the micro- or nanoparticles that, owing to capillary forces, will penetrate into the matrix bulk. Subsequent drying of thus filler-loaded cryogels or cryostructurates will yield the composite materials (e.g., see [ 68 , 272 , 388 , 389 , 391 , 395 ]).…”