Synthesis and Characterization of Divalent Transition Metal Complexes Containing Thiosemicarbazone Ligands

Mishra, Prem Mohan; Jha, M. K.; C, Ram; Kumar, Chandan

doi:10.13005/ojc/290453

Cited by 4 publications

(4 citation statements)

References 7 publications

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“…Therefore, as per literature trends, thiosemicarbazone ligands can function as neutral tridentate chelators in the thione form or anionic chelators in the thiolate forms. [9][10] In 3, the btm chelator functions as a neutral bidentate chelator via the N imino N benzothiazole donor set, which corresponds well with trends found within literature. In particular, ruthenium compounds with benzothiazole moieties have shown tendencies in coordination affinity, whereby the N benzothiazole donor atom bonds to soft acceptor metal centers such as ruthenium(II).…”

Section: Resultssupporting

confidence: 84%

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Biomolecular Interactions of Cytotoxic Ruthenium Compounds with Thiosemicarbazone or Benzothiazole Schiff Base Chelates

et al. 2022

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Herein we illustrate the formation and characterization of new paramagnetic ruthenium compounds, trans-P-[RuCl(PPh 3 ) 2 (pmt)]Cl(1)Agarose gel electrophoresis experiments of the metal compounds illustrated dose-dependent binding to gDNA by 1-3, while methylene blue competition assays suggested that 1 and 2 are also DNA intercalators. Assessment of the effects of the compounds on topoisomerase function indicated that 1-3 are capable of inhibiting topoisomerase I activity in terms of the ability to nick supercoiled plasmid DNA. The cytotoxic activities of the metal complexes were determined against a range of cancer cell lines versus a nontumorigenic control cell line, and the complexes were, in general, more cytotoxic towards the cancer cells, displaying IC 50 values in the low micromolar range. Time-dependent stability studies showed that in the presence of strong nucleophilic species (such as DMSO), the chloride co-ligands of 1-3 are rapidly substituted by the former as proven by the suppression of the substitution reactions in the presence of an excess amount of chloride ions. The metal complexes are significantly stable in both DCM and an aqueous phosphate buffer containing 2 % DMSO.

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Section: Resultssupporting

confidence: 84%

“…[Ru(pybs)(PPh 3 )(CH 3 CN) 2 Cl]Cl (pybs = 2-(2pyridyl)benzothiazole). [10][11] Furthermore, the metal compounds 1-3 are stable in air, soluble in chloroform, dichloromethane, dimethyl sulfoxide and tetrahydrofuran, as well as partially soluble in alcoholic media and acetonitrile.…”

Section: Resultsmentioning

confidence: 99%

Biomolecular Interactions of Cytotoxic Ruthenium Compounds with Thiosemicarbazone or Benzothiazole Schiff Base Chelates

et al. 2022

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“…A broad band at 3400 and a new band at 865 in the spectra of the copper complex were assigned to OH group of a water molecule. 27 The strong band observed at 1609 cm -1 in the spectra of the ligand is characteristic of azomethine stretching vibrations. Upon complexation, this vibration shifted to the lower frequency range of 1585-1592 cm -1 , indicating bonding of unsaturated nitrogen of azomethane group to the metal ions.…”

Section: Infrared Spectramentioning

confidence: 99%

Synthesis, characterization and biological studies of cobalt(II), nickel(II), copper(II) and zinc(II) complexes of vanillin-4-methyl-4-phenyl-3-thiosemicarbazone

Kumar¹,

Nath²

2019

J Chem Sci

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Complexes of vanillin-4-methyl-4-phenyl-3-thiosemicarbazone with cobalt(II), nickel((II), copper(II) and zinc(II) metal ions were synthesized and characterized by elemental analysis, molar conductance, magnetic moment, infrared spectra, electronic spectra, 1 H and 13 C NMR, mass spectrum and thermal analysis. The low molar conductance values indicate that all the complexes are non-electrolytes. Spectral studies indicate that the ligand act in a tridentate manner coordinating with the metal ion through sulphur, oxygen and nitrogen atoms. Based on magnetic moment measurements, spectral studies and thermal analysis, suitable geometry was proposed for the metal complexes. Thermal stability of the complexes was ascertained on the basis of thermo gravimetric analysis and the lattice parameters, space group and grain size of the ligand and complexes were determined by using powder XRD measurements. Surface morphology of ligand and complexes were studied using SEM analysis. Antimicrobial studies were carried out against gram-positive, gram-negative bacteria and two fungal pathogens.

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“…They coordinate to the metal ion through sulfur and nitrogen of the hydrazine (Chandra et al, 2007and Salman et al, 2014. This class of compounds has received great interest from chemist and other scientist due to their bonding modes, biological activities, structural diversity, and ion-sensing ability (Mishra et al, 2013). Moreover, due to the presence of various manageable sets of sulfur and nitrogen atoms capable of donating electrons pair, which makes them useful as chelating ligands in the preparation of metal complexes (Singh et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, and in Vitro Antimicrobial Studies on Nickel (Ii) and Copper (Ii) Complexes of Schiff Base Derived From Isatin (1h-Indole-2,3-Dione) Ands Thiosemicarbazone

Bello,

Aliyu,

Hussaini

2023

FJS

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The Schiff base ligand was obtained from the condensation of Isatin and Thiosemicarbazide. Its Nickel(II) and Copper(II) complexes were synthesized by the solutions of the ligand and that of the chloride of the correspond metal in the ratio of 2:1. The complexes obtained were characterized by FTIR, melting point/decomposition temperature determination, atomic absorption spectroscopy (AAS), magnetic susceptibility, and molar conductance and solubility tests. The complexes showed moderate values of decomposition temperatures. Infrared spectral data of the ligand and the complexes indicated coordination of the ligand to the metal (II) ion via azomethine nitrogen, indole oxygen and thionine sulphur; thus acting as a tridentate ligand. The complexes showed an effective magnetic moments of 3.34 BM and 0.94 BM for the NI(II) and Cu(II) respectively which suggests an octahedral geometry. The molar conductivities of 17.1 Ω -1 cm 2 mol -1 for the Ni(II) and 9.1 Ω -1 cm 2 mol -1 for Cu(II) complexes indicated that these complexes are non-electrolytic. The results of the AAS and the empirical formula indicated that, the Schiff base is monobasic and tridentate towards the metal ions. The ligand and the complexes were tested for antimicrobial activity against Staphylococcus aureus, Salmonella typhimurium, Escherichia coli (bacteria); Aspergillus flavus, Aspergillus fumigatus and Mucor species (fungi). Amoxicillin and Ketoconazole were used as positive control for the bacteria and fungi isolates respectively. The results showed that the complexes are more active than the free ligand but not as active as the standard drugs.

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Synthesis and Characterization of Divalent Transition Metal Complexes Containing Thiosemicarbazone Ligands

Cited by 4 publications

References 7 publications

Biomolecular Interactions of Cytotoxic Ruthenium Compounds with Thiosemicarbazone or Benzothiazole Schiff Base Chelates

Biomolecular Interactions of Cytotoxic Ruthenium Compounds with Thiosemicarbazone or Benzothiazole Schiff Base Chelates

Synthesis, characterization and biological studies of cobalt(II), nickel(II), copper(II) and zinc(II) complexes of vanillin-4-methyl-4-phenyl-3-thiosemicarbazone

Synthesis, Characterization, and in Vitro Antimicrobial Studies on Nickel (Ii) and Copper (Ii) Complexes of Schiff Base Derived From Isatin (1h-Indole-2,3-Dione) Ands Thiosemicarbazone

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