Synthesis and Characterization of Dextran coated Iron Oxide Nanoparticles as a T1 Contrast Agent

Ra’ad, Z; Al-Karam, Logean Qadri; Al-Sahib, Nabeel Kadim Abid

doi:10.1088/1742-6596/2114/1/012037

Cited by 3 publications

(2 citation statements)

References 10 publications

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“…The strong band centered at 3400 cm −1 is representative of the OH bonds, the peaks around 2920 cm −1 and around 2850 cm −1 are due to the asymmetric and symmetric stretching vibration of the CH 2 groups of the Dextran polymer, respectively, and the band located at 1643 cm −1 is assigned to the C-C (in-plane of the ring). The band at 1157 cm −1 is probably related to the C-O stretching vibration of the glycosidic bonds, and the strong and sharp band at 1013 cm −1 is attributed to the C-O stretching vibration of the hydroxyl groups in the Dextran polymer [29]. In the spectra of SPIONs coated with Dextran (SP R/P -Dx and SP pH -DX), distinctive absorption peaks emerge, indicating the successful coating of dextran onto the SPION surface.…”

Section: Uv-vis and Atr-ftirmentioning

confidence: 99%

Influence of SPION Surface Coating on Magnetic Properties and Theranostic Profile

Ferreira-Filho,

Morais,

Vieira

et al. 2024

Molecules

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This study aimed to develop multifunctional nanoplatforms for both cancer imaging and therapy using superparamagnetic iron oxide nanoparticles (SPIONs). Two distinct synthetic methods, reduction–precipitation (MR/P) and co-precipitation at controlled pH (MpH), were explored, including the assessment of the coating’s influence, namely dextran and gold, on their magnetic properties. These SPIONs were further functionalized with gadolinium to act as dual T1/T2 contrast agents for magnetic resonance imaging (MRI). Parameters such as size, stability, morphology, and magnetic behavior were evaluated by a detailed characterization analysis. To assess their efficacy in imaging and therapy, relaxivity and hyperthermia experiments were performed, respectively. The results revealed that both synthetic methods lead to SPIONs with similar average size, 9 nm. Mössbauer spectroscopy indicated that samples obtained from MR/P consist of approximately 11–13% of Fe present in magnetite, while samples obtained from MpH have higher contents of 33–45%. Despite coating and functionalization, all samples exhibited superparamagnetic behavior at room temperature. Hyperthermia experiments showed increased SAR values with higher magnetic field intensity and frequency. Moreover, the relaxivity studies suggested potential dual T1/T2 contrast agent capabilities for the coated SPpH-Dx-Au-Gd sample, thus demonstrating its potential in cancer diagnosis.

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Section: Uv-vis and Atr-ftirmentioning

confidence: 99%

Influence of SPION Surface Coating on Magnetic Properties and Theranostic Profile

Ferreira-Filho,

Morais,

Vieira

et al. 2024

Molecules

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show abstract

“…Dextran contains repeating units of glucose molecules, and the CH2 groups in these units contribute to these peaks. The band at 1110 cm -1 is probably related to the C-O stretching vibration of the glycosidic bonds and the band at 1010 cm -1 is attributed to the C-O stretching vibration of the hydroxyl groups in the Dextran polymer [32].…”

Section: Uv-vis and Atr-ftirmentioning

confidence: 99%

Influence of SPIONs Surface Coating on Magnetic Properties and Theranostic Profile

Ferreira-Filho,

Morais,

Vieira

et al. 2024

Preprint

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This study aimed to develop multifunctional nanoplatforms for both cancer imaging and therapy using superparamagnetic iron oxide nanoparticles (SPIONs). Two distinct synthetic methods, reduction-precipitation (MR/P) and co-precipitation at controlled pH (MpH), were explored, including the assessment of coating’s influence, namely dextran and gold, on their magnetic properties. These SPIONs were further functionalized with gadolinium to act as dual T1/T2 contrast agents for magnetic resonance imaging (MRI). Parameters such as size, stability, morphology, and magnetic behavior were evaluated by a detailed characterization analysis. To assess their efficacy in imaging and therapy, relaxivity and hyperthermia experiments were performed, respectively. The results revealed that both synthetic methods lead to SPIONs with similar average, 9 nm. Mössbauer spectroscopy indicated that samples obtained from MR/P consist of approximately 11-13% of Fe present in magnetite, while samples obtained from MpH have higher content, of 33%-45%. Despite coating and functionalization, all samples exhibited superparamagnetic behavior at room temperature. Hyperthermia experiments showed increased SAR values with higher magnetic field intensity and frequency. Moreover, the relaxivity studies suggested potential dual T1/T2 contrast agent capabilities for the coated SPpH-Dx-Au-Gd sample, thus demonstrating its potential in cancer diagnosis.

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Synthesis and characterization of a novel ternary magnetic composite for the enhanced adsorption capacity to remove organic dyes

Osman,

Alsaiari,

Amari

et al. 2024

Reviews on Advanced Materials Science

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Using an easy mechanical agitation process at room temperature, a metal–organic framework (MOF) based on metallic Zn(ii), organic linker benzene-1,3,5-tricarboxylic acid (Zn-BTC), Fe3O4 nanoparticles, and nanocellulose are combined to create a novel composite material called Fe3O4/NC/MOF. Various tools were used to characterize the created composite. Congo red, Basic Blue 54 (BB 54), Basic Violet 14 (BV 14), and Acid red 88 (AR 88) dyes were effectively eliminated from water using Fe3O4/NC/MOF. A number of variables were investigated, including pH, temperature, contact time, initial dye concentration, and adsorbent dosage. To understand the specific adsorption process, a number of kinetic models were used, including the intra-particle diffusion model, Elovich’s kinetic model, pseudo-first-order, and pseudo-second-order kinetic models. The most accurate description of dye sorption kinetics comes from the pseudo-second-order kinetic model. Also, the Langmuir model is more accurate to describe isotherms than Freundlich and Temkin models. Furthermore, thermodynamic parameters were obtained and examined, including enthalpy (ΔH), Gibbs free energy (ΔG), and entropy (ΔS). After four cycles, the Fe3O4/NC/MOF demonstrated good recyclability. According to experimental research, this adsorbent is promising to enhance the quality of environmental water that has been tainted with organic dyes.

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Synthesis and Characterization of Dextran coated Iron Oxide Nanoparticles as a T1 Contrast Agent

Cited by 3 publications

References 10 publications

Influence of SPION Surface Coating on Magnetic Properties and Theranostic Profile

Influence of SPION Surface Coating on Magnetic Properties and Theranostic Profile

Influence of SPIONs Surface Coating on Magnetic Properties and Theranostic Profile

Synthesis and characterization of a novel ternary magnetic composite for the enhanced adsorption capacity to remove organic dyes

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