Synthesis and characterization of collagen/hyaluronan/chitosan composite sponges for potential biomedical applications

<i>IN VITRO</i> TESTING OF MODIFIED COLLAGEN/ HYALURONAN/BETA-GLUCAN SCAFFOLD

“…Similar structural characteristics were observed by other authors in various composite scaffold based on the collagen and hyaluronic acid but also collagen and chitosan (Arana et al, 2013;Lin et al, 2009).…”

Development and Characterization of Acellular Extracellular Matrix Scaffolds from Porcine Menisci for Use in Cartilage Tissue Engineering

“…Formic acid is a well-known decalcifying agent in histology of bone biopsies but was previously reported to cause DNA hydrolysis and degradation. 54 With formic acid treatment for 2 h, the amount of DNA remained was 37.20 -6.53 ng/mg in the dry menisci tissue. According to an accepted criterion for acellularity (less than 50 ng/mg dry tissue weight), 55 formic acid-treated scaffold is considered as an acellular scaffold.…”

The past, present and future in scaffold-based tendon treatments

“…To a smaller extent, chitosan / alginate composites have been assessed for tendon repair, with in vitro data demonstrating adherence of rabbit tendon fibroblast and increased collagen type I expression and mechanical properties [383]. Preclinical data of chitosan and chitosan / HA scaffolds have demonstrated enhanced tissue-specific ECM production and improved mechanical strength, as compared to the control treatments [384][385][386][387]. Polyhydroxyalkanoates, natural polymers produced by bacteria, have also shown great potential in tissue engineering [388].…”