Synthesis and characterization of chitosan‐polycaprolactone blended with organoclay for control release of doxycycline

Sahoo, Sarmila; Sasmal, Abhisek; Nayak, Padma L.

doi:10.1002/app.32474

Cited by 49 publications

(19 citation statements)

References 47 publications

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“…11b) was well in agreement with reported data (Sahoo et al 2010;Wu, 2003). The characteristic peaks of polycaprolactone (PCL) at 3300-3700, 1730.15, 850-1480, and 731.02 cm -1 all appeared in its spectrum.…”

Section: Infrared Spectroscopysupporting

confidence: 91%

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Unveiling the compatibility of eugenol with formulation excipients by systematic drug-excipient compatibility studies

et al. 2015

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Background: The drug-excipient compatibility studies were carried out with the possible excipients viz. Tween 80, Carbopol 940, chitosan, sodium alginate, and polycaprolactone (PCL) for their possible use in the formulation of eugenol loaded nanoemulsion gels and nanoparticles. Methods: The eugenol-excipient compatibility studies were carried out by visual observations, differential scanning calorimetry (DSC), infrared spectroscopy (FTIR), and high-performance thin-layer chromatography (HPTLC). Results: No notable change was observed in the samples on visual observation. From the results of the DSC studies, to a much extent, it was assumed that eugenol was not subjected to any interaction with the selected excipients for the proposed nanoemulsion gel and nanoparticles. But in some cases viz. polycaprolactone and Carbopol, though not to a significant level, slight deviation of the nature and position of the endothermic peaks of eugenol were observed. The results of the IR spectroscopy confirmed the compatibility of eugenol with Tween 80, Carbopol 940, chitosan, sodium alginate, and polycaprolactone. The retention factor of the HPTLC densitogram peaks for all the physical mixtures was well within the retention factor (R f ) value range observed for pure eugenol. Conclusions: The study results confirmed that eugenol is compatible with the selected excipients for the development of nanoemulsion gels and nanoparticles.

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Section: Infrared Spectroscopysupporting

confidence: 91%

“…9b) was well in agreement with reported data (Lawrie et al 2007;Sahoo et al 2010). The FTIR spectrum of chitosan showed its characteristic peaks at 3275.13 (O-H and N-H stretch) ) were present in the physical mixture (Fig.…”

Section: Infrared Spectroscopysupporting

confidence: 91%

Unveiling the compatibility of eugenol with formulation excipients by systematic drug-excipient compatibility studies

et al. 2015

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“…Doxycycline is a non-charged antibiotic belonging to the tetracycline family that has recently been incorporated to chitosan composites incorporating an organoclay [115]. The only objection of these DDS systems can be related to the use of organoclays that contain toxic alkylammonium species (cationic surfactants), which can produce mild skin and respiratory irritation or anaphylactic reactions amongst other health effects.…”

Section: Chitosan-clay Composites As Drug Delivery Systemsmentioning

confidence: 99%

Chitosan-Clay Bio-Nanocomposites

Darder

Ruiz‐Hitzky

2012

Environmental Silicate Nano-Biocomposites

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The present review chapter includes an overview on the current state-of-art of chitosan-clay based bio-nanocomposites. In the same way than conventional nanocomposites, these biohybrid materials also exhibit both structural and functional properties together with biocompatibility and biodegradability, which can be of great interest for different applications. Four main areas of interest have been identified showing examples of applications as green nanocomposites, bio-nanocomposites addressed to biomedical purposes (tissue engineering and drug delivery), environmental remediation and electroanalytical devices. Finally, examples of bio-nanocomposites based on chitosan assembled to other inorganic solids have been introduced to show the versatility of this biopolymer for development of diverse type of advanced functional materials.

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“…Significant areas where advanced biomaterials are applied involve the production of nano-and micro-particles for drug delivery and controlled release applications [229], two-dimensional structures, e.g. membranes for…”

Section: Biosourced Polymers Blends and Compositesmentioning

confidence: 99%

Recent Strategies for the Development of Biosourced-Monomers, Oligomers and Polymers-Based Materials: A Review with an Innovation and a Bigger Data Focus

Rebouillat¹,

Pla²

2016

JBNB

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After setting the ground of the quantum innovation potential of biosourced entities and outlining the inventive spectrum of adjacent technologies that can derive from those, the current review highlights, with the support of Bigger Data approaches, and a fairly large number of articles, more than 250 and 10,000 patents, the following. It covers an overview of biosourced chemicals and materials, mainly biomonomers, biooligomers and biopolymers; these are produced today in a way that allows reducing the fossil resources depletion and dependency, and obtaining environmentallyfriendlier goods in a leaner energy consuming society. A process with a realistic productivity is underlined thanks to the implementation of recent and specifically effective processes where engineered microorganisms are capable to convert natural non-fossil goods, at industrial scale, into fuels and useful high-value chemicals in good yield. Those processes, further detailed, integrate: metabolic engineering involving 1) system biology, 2) synthetic biology and 3) evolutionary engineering. They enable acceptable production yield and productivity, meet the targeted chemical profiles, minimize the consumption of inputs, reduce the production of by-products and further diminish the overall operation costs. As generally admitted the properties of most natural occurring biopolymers (e.g., starch, poly (lactic acid), PHAs.) are often inferior to those of the polymers derived from petroleum; blends and composites, exhibiting improved properties, are now successfully produced. Specific attention is paid to these aspects. Then further evidence is provided to support the important potential and role of products deriving from the biomass in general. The need to en- ter into the era of Bigger Data, to grow and increase the awareness and multidimensional role and opportunity of biosourcing serves as a conclusion and future prospects. Although providing a large reference database, this review is largely initiatory, therefore not mimicking previous classic reviews but putting them in a multiplying synergistic prospective.

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Synthesis and characterization of chitosan‐polycaprolactone blended with organoclay for control release of doxycycline

Cited by 49 publications

References 47 publications

Unveiling the compatibility of eugenol with formulation excipients by systematic drug-excipient compatibility studies

Unveiling the compatibility of eugenol with formulation excipients by systematic drug-excipient compatibility studies

Chitosan-Clay Bio-Nanocomposites

Recent Strategies for the Development of Biosourced-Monomers, Oligomers and Polymers-Based Materials: A Review with an Innovation and a Bigger Data Focus

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