Synthesis and Characterization of Chitosan Based Multilayer and pH Sensitive Co-Polymeric System for the Targeted Delivery of 5-Fluorouracil, an In Vitro Study

Abstract

The principle aspiration is to develop a core shell carrier system for 5-Fluorouracil. Trisodiumcitrate crosslinked chitosan containing 5-Fluorouracil coated with cellulose acetate acts as core and copolymer of N-vinyl-2-pyrrolidone, 2-hydroxyethylmethacrylate, and itaconic acid act as shell. SEM, FTIR, and XRD studies were undertaken to characterize the samples. Swelling experiments were performed as a function of time, temperature, pH, and in simulated gastric and intestinal pH. Swelling factor was calculated for three different ions. Drug loading efficiency and in vitro release studies was done and compared. Drug delivery mechanism was found out by using Peppa's equation.

Synthesis and characterization of silane coated magnetic nanoparticles/glycidylmethacrylate-grafted-maleated cyclodextrin composite hydrogel as a drug carrier for the controlled delivery of 5-fluorouracil

“…In the DDS, the peaks corresponding to Si-O-Si, NC_O group were retained, but peaks corresponding to NC_Cb stretching were absent indicating the polymerization between vinylic functionalization of macromonomers in the presence of crosslinker and initiator. In the 5-FU loaded DDS, characteristic peaks of 5-FU at 3387 cm − 1 (N-H stretching) and 1705 and 1578 cm − 1 (due to C_O stretching) were retained with little modification indicating the hydrogen bonding interaction between the drug and DDS [28]. Due to the interaction between drug and DDS, bond length increases, causing decrease in stretching frequency, which resulted in wave number shift from higher to lower frequency region [29].…”

The design of pH-sensitive chitosan-based formulations for gastrointestinal delivery

“…Overall, these polymers can maintain rigid status when passing through the stomach, whereas they become soluble at the higher intestine pH and release the drug core ready for action. Moreover, the presence of coating materials can dramatically increase the entrapment efficiency as well as decrease the release rate of therapeutic agents according to the published literature [58].…”

5-Fluorouracil Encapsulated Chitosan-Cellulose Fiber Bionanocomposites: Synthesis, Characterization and In Vitro Analysis towards Colorectal Cancer Cells

“…The above side-effects can be abated by encapsulation of a minimal drug dosage into a biocompatible drug carrier. Of this, 5FU has been encapsulated in many drug carrier platform, such as, chitosan [ 18 ] and cellulose [ 19 , 20 ]. In this matter, some polysaccharides, including cellulose, chitosan, starch, xanthan gum, hyaluronic acid, and carrageenans can display pH/thermos-responsive properties to control the drug release dosage with effective anticancer actions [ 21 ].…”