The design of pH-sensitive chitosan-based formulations for gastrointestinal delivery

Du, Hongchuan; Liu, Mengrui; Yang, Xiaoye; Zhai, Guangxi

doi:10.1016/j.drudis.2015.03.002

Cited by 131 publications

(46 citation statements)

References 61 publications

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“…3. Chitosan used as a polymer for microparticles becomes soluble under low pH condition due to protonation of amino group that leads to increase the release of drug at lower pH [18]; it was reported that microspheres almost released all entrapped drug at pH 1.2, however, nearly 70% of the drug was released over 3 h at pH 3.0 [18]. These results are in agreement with the current study showing that increase in pH leads to slower release of the drug.…”

Section: In-vitro Drug Releasesupporting

confidence: 92%

Characterization of furazolidone-chitosan based spray dried microparticles regarding their drug release and mucin adsorptive properties

2016

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Section: In-vitro Drug Releasesupporting

confidence: 92%

Characterization of furazolidone-chitosan based spray dried microparticles regarding their drug release and mucin adsorptive properties

2016

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“…Furthermore, the SA layer could have prevented the gastric degradation of CH, because the positive charges from CH reduced solubility at low pH. However, at around neutral pH, a higher amount of negative charges sequester positive CH charges, resulting in dissolution of the CH/SA complex and increase in the release of Zn 2+ in the middle enteric region [19]. ZnO/CA and ZnO/CAT showed good release of Zn 2+ in SEF, triggered by the change in the pH.…”

Section: Discussionmentioning

confidence: 99%

In vitro physiological and antibacterial characterization of ZnO nanoparticle composites in simulated porcine gastric and enteric fluids

et al. 2017

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BackgroundDiarrhea in piglets is one of the main causes of animal death after weaning; zinc oxide (ZnO) has been used in high doses for the control of this sickness. The aim of this study was to determine the physicochemical properties of ZnO nanoparticles synthesized and immobilized on a chitosan/alginate (CH/SA) complex and investigate the antimicrobial activity and in vitro release profile of zinc (Zn2+) from these new compounds. The ZnO nanoparticles composites were prepared and combined with CH/SA or CH/SA and sodium tripolyphosphate (TPP). The structure and morphology of the composites were analyzed by characterization methods such as X-ray diffraction, FTIR spectroscopy, thermogravimetric analysis, atomic absorption spectrophotometry and scanning electron microscopy.ResultsThe crystallite size of ZnO nano was 17 nm and the novel ZnO composites were effective in protecting ZnO in simulated gastric fluid, where Zn2+ reached a concentration six-fold higher than the levels obtained with the unprotected commercial-zinc oxide. In addition, the novel composites suggest effective antimicrobial activity against Escherichia coli and Staphylococcus aureus. ConclusionsThe results described herein suggest that the novel nano composites may work as an alternative product for pig feeding as verified by the in vitro assays, and may also contribute to lower the zinc released in the environment by fecal excretion in animals waste.

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“…Since the microenvironment of the atherosclerotic plaque is mildly acidic [26], drug delivery systems sensitive to changes in pH in lesions are designed to improve the targeted delivery of drugs, thereby enhancing drug efficacy [34]. To investigate the pH sensitivity of RAP@PFN1-CD-MNPs, hydrolysis of these NPs was studied under various pH conditions.…”

Section: In Vitro Drug Release Studiesmentioning

confidence: 99%

Construction of dual nanomedicines for the imaging and alleviation of atherosclerosis

Zhang

Gao

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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Magnetic resonance imaging (MRI) is an essential tool for the diagnosis of atherosclerosis, a chronic cardiovascular disease. MRI primarily uses superparamagnetic iron oxide (SPIO) as a contrast agent. However, SPIO integrated with therapeutic drugs has rarely been studied. In this study, we explored biocompatible paramagnetic iron-oxide nanoparticles (NPs) in a complex with low pH-sensitive cyclodextrin for the diagnostic imaging and treatment of atherosclerosis. The NPs were conjugated with profilin-1 antibody (PFN1) to specifically target vascular smooth muscle cells (VSMCs) in the atherosclerotic plaque and integrated with the anti-inflammatory drug, rapamycin. The PFN1-CD-MNPs were easily binded to the VSMCs, indicating their good biocompatibility and low renal toxicity over the long term. Ex vivo near-infrared fluorescence (NIRF) imaging and in vivo MRI indicated the accumulation of PFN1-CD-MNPs in the atherosclerotic plaque. The RAP@PFN1-CD-MNPs alleviated the progression of arteriosclerosis. Thus, PFN1-CD-MNPs served not only as multifunctional imaging probes but also as nanovehicles for the treatment of atherosclerosis.

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The design of pH-sensitive chitosan-based formulations for gastrointestinal delivery

Cited by 131 publications

References 61 publications

Characterization of furazolidone-chitosan based spray dried microparticles regarding their drug release and mucin adsorptive properties

Characterization of furazolidone-chitosan based spray dried microparticles regarding their drug release and mucin adsorptive properties

In vitro physiological and antibacterial characterization of ZnO nanoparticle composites in simulated porcine gastric and enteric fluids

Construction of dual nanomedicines for the imaging and alleviation of atherosclerosis

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