Synthesis and characterization of chitosan-g-poly(ethylene glycol)-folate as a non-viral carrier for tumor-targeted gene delivery

Synthesis of folate- pegylated polyester nanoparticles encapsulating ixabepilone for targeting folate receptor overexpressing breast cancer cells

“…Furthermore, due to its low melting point (T m = 44°C), which is close to the physiological body temperature [9,10], PPSu could be used as drug nanocarrier appropriate for selective drug release at the tumor site using local hyperthermia. In order to avoid the rapid removal of these nanoparticles from systemic circulation after intravenous administration, due to rapid uptake by reticular endothelial system (RES), pegylated PPSu nanoparticles based on PEG-PPSu copolymers have been developed [11][12][13][14][15][16][17][18]. Although pegylation of nanoparticles surface can lead to their preferential accumulation in tumor tissue due to the enhanced permeability and retention (EPR) phenomenon, it does not appear to increase the uptake of nanoparticles, and consequently of their drug load, by cancer cells [19].…”

Efficient Synthesis and Characterization of Monoprotected Symmetrical Poly(Ethylene Glycol) Diamine

“…[4][5][6][7] Versatile functional groups at the terminal sites of PEG polymers enable the attachment of various biomolecules such as proteins, nucleic acids, and carbohydrates. [8][9][10][11] Of the numerous functional PEG polymers, heterobifunctional PEG derivatives are often used as cross-linkers or spacers between two biomolecules. [12][13][14] The monofunctionalization of symmetric bifunctional PEG derivatives by solution-phase method results in a mixture of the desired monofunctional product as well as bifunctional substituted side product.…”

Preparation and characterization of FA conjuagted MPEG-PLA polymer nanoparticles loaded with 10-hydroxycamptothecin for sustained drug release

“…It has long been believed that folate (FA) is a good target molecule because of the over-expression FA receptors in cancer cells. [8,9] The NPs with the functionalization of FA could latch onto FA receptors of the cancer and thus enhance their cellular uptake. Herein, we used a dialysis technique to prepared the HCPT loaded, MPEG-PLA-FA (monomethoxy polyethylene glycol-polylactide-folate) modified polymeric NPs, which possessed improved the drug sustained release properties.…”