Synthesis and characterization of cationic lipid coated magnetic nanoparticles using multiple emulsions as microreactors

Abstract

The aim of this study was to develop a novel iron oxide nanoparticle synthesis method with in-situ surface coating. For this purpose multiple emulsions were used as microreactors for the first time and magnetic iron oxide particles synthesized in the core of cationic solid lipid nanoparticles. DLS, SEM, TEM, VSM, Raman Spectrometer, XRD, and XPS techniques were performed for characterization of the magnetic nanoparticles. Obtained magnetic nanoparticles are superparamagnetic and no additional process was needed for surface adjustments. They are positively charged as a result of cationic lipid coating and has appropriate particle size (< 30 nm) for drug or nucleic acid delivery. Structure analysis showed that magnetic core material is in the form of magnetite. Saturation magnetization value was measured as 15-17 emu g −1 for lipid coated magnetic nanoparticles obtained by multiple emulsion method which is reasonably sufficient for magnetic targeting.

Relationship between structure and molecular interactions in monolayers of specially designed aminolipids

“… 5–7 Furthermore, cationic lipids are useful tools in materials science. 8–13 Malonic acid diamides are cationic lipids developed in our research groups. 14 The chronology of their development resulted in three “generations” of malonic acid diamides.…”

Preparation and Evaluation of Poly(lactic acid)/Poly(vinyl alcohol) Nanoparticles Using the Quality by Design Approach

“…Nanoparticles are drug delivery systems with sizes ranging from 1 to 1000 nm, which overcome biological barriers and facilitate diagnosis, treatment, follow-up of the disease and treatment responses. − For these reasons, polymeric nanoparticle formulations consisting of PLA and PVA were prepared that can be used as drug delivery systems in this study.…”

Design of Liposome Formulations for CRISPR/Cas9 Enzyme Immobilization: Evaluation of 5-Alpha-Reductase Enzyme Knockout for Androgenic Disorders

“…DLS measurements were performed at 25 °C and reported as mean intensity-weighted distributions of AD measurements. 32,33 A Carl ZEISS Sigma 300 VP scanning electron microscope (SEM�ZEISS Group, Germany) was used for morphological investigations. 34 Samples were coated with a conductive gold layer using a He Quorum Q150R ES (Quorum Technologies, UK) under a high vacuum prior to analysis.…”