Synthesis and Characterization of Carborane Functionalized Dendronized Polymers as Potential Boron Neutron Capture Therapy Agents

Benhabbour, S. Rahima; Adronov, Alex

doi:10.1021/bk-2008-0977.ch014

Cited by 4 publications

(4 citation statements)

References 22 publications

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“…Adronov et al utilized an RDRP method, nitroxide mediated polymerization (NMP) to synthesize carborane functionalized dendronized polymers. 72 In a first step, carborane-functionalized styrene was polymerized. Dendronization of the resulting polymer was accomplished through the divergent growth of bis-MPA to the [G4].…”

Section: Dendronized Polymer Hybridsmentioning

confidence: 99%

Dendritic architectures based on bis-MPA: functional polymeric scaffolds for application-driven research

2013

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Dendritic polymers are highly branched, globular architectures with multiple representations of functional groups. These nanoscale organic frameworks continue to fascinate researchers worldwide and are today under intensive investigation in application-driven research. A large number of potential application areas have been suggested for dendritic polymers, including theranostics, biosensors, optics, adhesives and coatings. The transition from potential to real applications is strongly dictated by their commercial accessibility, scaffolding ability as well as biocompatibility. A dendritic family that fulfills these requirements is based on the 2,2-bismethylolpropionic acid (bis-MPA) monomer. This critical review is the first of its kind to cover most of the research activities generated on aliphatic polyester dendritic architectures based on bis-MPA. It is apparent that these scaffolds will continue to be in the forefront of cutting-edge research as their structural variations are endless including dendrons, dendrimers, hyperbranched polymers, dendritic-linear hybrids and their hybridization with inorganic surfaces.

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Section: Dendronized Polymer Hybridsmentioning

confidence: 99%

Dendritic architectures based on bis-MPA: functional polymeric scaffolds for application-driven research

2013

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“…In 2008, Adronov and co-workers extended their library of synthons containing carborane units by functionalising one side of the carborane with a styrene entity and the other side with the aliphatic polyester dendrimer backbone, which is water soluble, biocompatible and biodegradable. 46 After nitroxide-mediated polymerisation and divergent growth of the dendrons, high-molecular-weight polymers with narrow dispersity were obtained, with a theoretical boron content of around 12% and a water solubility of around 1 mg mL −1 (Fig. 11).…”

Section: Polymer Chemistrymentioning

confidence: 99%

Polymers and boron neutron capture therapy (BNCT): a potent combination

Pitto-Barry

2021

Polym. Chem.

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“…The Adronov group at McMaster University creatively employed NMP to functionalize carbon nanotubes [ 114 ] and to dendronize carborane functionalized styrene precursors for cancer therapy agents. [ 115,116 ] In the first case, poly(styrene) (PS) and poly(styrene‐ block ‐acrylic acid) (PS‐ b ‐PAA; derived from the PS‐ b ‐poly( tert ‐butyl acrylate)) were prepared using a TIPNO‐derived unimolecular initiator. The TIPNO‐terminated PS or PS‐ b ‐PtBA were heated to 125°C with the cleaved polymer radical attaching to single walled carbon nanotubes (SWNT) through radical coupling.…”

Section: The 2000smentioning

confidence: 99%

“…Carborane functionalized styrene is polymerized using a TIPNO‐based initiator, which is further functionalized to produce various generations of dendronized polymers for application as boron neutron therapy agents. Reprinted with permission from Benhabbour et al [ 116 ] Copyright 2008, American Chemical Society…”

Section: The 2000smentioning

confidence: 99%

History of nitroxide mediated polymerization in Canada

Marić

2021

Can J Chem Eng

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Nitroxide mediated polymerization (NMP), sometimes known as stable free radical polymerization (SFRP), is considered one of the main types of reversible deactivation radical polymerization (RDRP) that have emerged as a major advance in polymer synthesis in the past 30 years. This review examines NMP's development from a uniquely Canadian perspective. Inspired by reports of a reversible equilibrium between the TEMPO persistent radical and a growing polymeric radical chain, researchers at the Xerox Research Centre of Canada (XRCC) reported radical polymerizations of styrene with hallmarks typically associated with living polymerizations: linear degree of polymerization of with conversion, narrow molecular weight distributions, and ability to re‐initiate the chain end with additional monomer. This effort expanded to polymerizations in dispersed aqueous media (eg, miniemulsion) and to polymerizations directed for various architectures (block, graft, star), but NMP was ultimately generally limited to styrenic monomers. Consequently, NMP trailed other RDRP methods, such as atom transfer radical polymerization (ATRP) and reversible addition fragmentation transfer polymerization (RAFT), due to its limited monomer choice. With the advent of second‐generation alkoxyamine initiators, however, the range of monomers polymerizable in a controlled manner greatly expanded to include acrylates, acrylamides, and eventually methacrylates (under certain conditions), providing renewed impetus towards using NMP. Consequently, Canadian researchers applied these new alkoxyamines for more versatile polymers, resulting in products such as stimuli‐responsive polymers, CO2‐switchable latexes, bio‐hybrid composites, organic photovoltaic materials, and photolithographic materials. The chronological progression of the developments in NMP from various Canadian laboratories highlights these achievements in new polymeric materials.

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Synthesis and Characterization of Carborane Functionalized Dendronized Polymers as Potential Boron Neutron Capture Therapy Agents

Cited by 4 publications

References 22 publications

Dendritic architectures based on bis-MPA: functional polymeric scaffolds for application-driven research

Dendritic architectures based on bis-MPA: functional polymeric scaffolds for application-driven research

Polymers and boron neutron capture therapy (BNCT): a potent combination

History of nitroxide mediated polymerization in Canada

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