Polymers and boron neutron capture therapy (BNCT): a potent combination

Pitto-Barry, Anaïs

doi:10.1039/d0py01392g

Cited by 36 publications

(30 citation statements)

References 55 publications

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“…Most of them consist of one or multiple boron clusters attached to the tumor-targeting molecule: Boron-loaded constructs can be addressed to tumor cells through specific peptides, antibodies, or other biomolecules affine to the cell surface proteins [ 2 , 9 ]. The use of dendrimers, liposomes, or nanotubes allows obtaining high boron-loaded agents [ 8 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Tumor Cell-Specific 2′-Fluoro RNA Aptamer Conjugated with Closo-Dodecaborate as A Potential Agent for Boron Neutron Capture Therapy

Vorobyeva

Дымова

Новопашина

et al. 2021

IJMS

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Boron neutron capture therapy (BNCT) is a binary radiotherapeutic approach to the treatment of malignant tumors, especially glioblastoma, the most frequent and incurable brain tumor. For successful BNCT, a boron-containing therapeutic agent should provide selective and effective accumulation of 10B isotope inside target cells, which are then destroyed after neutron irradiation. Nucleic acid aptamers look like very prospective candidates for carrying 10B to the tumor cells. This study represents the first example of using 2′-F-RNA aptamer GL44 specific to the human glioblastoma U-87 MG cells as a boron delivery agent for BNCT. The closo-dodecaborate residue was attached to the 5′-end of the aptamer, which was also labeled by the fluorophore at the 3′-end. The resulting bifunctional conjugate showed effective and specific internalization into U-87 MG cells and low toxicity. After incubation with the conjugate, the cells were irradiated by epithermal neutrons on the Budker Institute of Nuclear Physics neutron source. Evaluation of the cell proliferation by real-time cell monitoring and the clonogenic test revealed that boron-loaded aptamer decreased specifically the viability of U-87 MG cells to the extent comparable to that of 10B-boronophenylalanine taken as a control. Therefore, we have demonstrated a proof of principle of employing aptamers for targeted delivery of boron-10 isotope in BNCT. Considering their specificity, ease of synthesis, and large toolkit of chemical approaches for high boron-loading, aptamers provide a promising basis for engineering novel BNCT agents.

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Section: Introductionmentioning

confidence: 99%

Tumor Cell-Specific 2′-Fluoro RNA Aptamer Conjugated with Closo-Dodecaborate as A Potential Agent for Boron Neutron Capture Therapy

Vorobyeva

Дымова

Новопашина

et al. 2021

IJMS

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“…At a dose of 20 mg/kg, 1 @FMX localized in tissues ranging from 0 to 65 μg of B per gram of tissue, suggesting that encapsulation of dodecaborate-based compounds in a polymer matrix can potentially have favorable effects on the biodistribution results. More broadly, this work suggests the potential importance of noncovalent interaction between boron clusters and polymers stemming from nonelectrostatic interactions and points to new avenues for creating hybrid boron-cluster-based nanomaterials without covalent attachment. − …”

Section: Discussionmentioning

confidence: 90%

Ex Vivo and In Vivo Evaluation of Dodecaborate-Based Clusters Encapsulated in Ferumoxytol Nanoparticles

et al. 2021

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Host-guest interactions represent a growing research area with recent work demonstrating an ability to chemically manipulate both host molecules as well as guest molecules to vary the type and strength of bonding. Much less is known about the interactions of guest molecules and hybrid materials containing similar chemical features to typical macrocyclic hosts. This work uses in vitro and in vivo kinetic analyses to investigate the interaction of closo-dodecahydrododecaborate derivatives with ferumoxytol, an iron oxide nanoparticle with a carboxylated dextran coating. We find that several boron cluster derivatives can become encapsulated into ferumoxytol and the lack of pH dependence in these interactions suggests that ion pairing, hydrophobic/hydrophilic, or hydrogen bonding are not the driving force for encapsulation in this system. Biodistribution experiments in BALB/c mice show that this system is nontoxic at the reported dosage and demonstrate that encapsulation of dodecaborate-based clusters in ferumoxytol can alter the biodistribution of guest molecules.

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“…Boron neutron capture therapy (BNCT) is a binary radiotherapeutic modality that relies on the injection of 10 Bcontaining compounds into tumors followed by thermal neutron beam irradiation. This approach has attracted considerable attention in the field of polymer science, 90 for instance through the design of boron-containing nanoparticles. However, traditional approaches result in low boron contents and tedious synthesis procedures.…”

Section: Poly(ethylene Glycol)-based Polymersmentioning

confidence: 99%

(Bio)degradable and Biocompatible Nano-Objects from Polymerization-Induced and Crystallization-Driven Self-Assembly

Zhu

Nicolas

2022

Biomacromolecules

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Polymerization-induced self-assembly (PISA) and crystallization-driven self-assembly (CDSA) techniques have emerged as powerful approaches to produce a broad range of advanced synthetic nano-objects with high potential in biomedical applications. PISA produces nano-objects of different morphologies (e.g., spheres, vesicles and worms), with high solids content (∼10−50 wt %) and without additional surfactant. CDSA can finely control the self-assembly of block copolymers and readily forms nonspherical crystalline nano-objects and more complex, hierarchical assemblies, with spatial and dimensional control over particle length or surface area, which is typically difficult to achieve by PISA. Considering the importance of these two assembly techniques in the current scientific landscape of block copolymer self-assembly and the craze for their use in the biomedical field, this review will focus on the advances in PISA and CDSA to produce nano-objects suitable for biomedical applications in terms of (bio)degradability and biocompatibility. This review will therefore discuss these two aspects in order to guide the future design of block copolymer nanoparticles for future translation toward clinical applications.

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Polymers and boron neutron capture therapy (BNCT): a potent combination

Abstract: This review describes the latest polymeric systems used as boron transporters for boron neutron capture therapy.

Cited by 36 publications

References 55 publications

Tumor Cell-Specific 2′-Fluoro RNA Aptamer Conjugated with Closo-Dodecaborate as A Potential Agent for Boron Neutron Capture Therapy

Tumor Cell-Specific 2′-Fluoro RNA Aptamer Conjugated with Closo-Dodecaborate as A Potential Agent for Boron Neutron Capture Therapy

Ex Vivo and In Vivo Evaluation of Dodecaborate-Based Clusters Encapsulated in Ferumoxytol Nanoparticles

(Bio)degradable and Biocompatible Nano-Objects from Polymerization-Induced and Crystallization-Driven Self-Assembly

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