(Bio)degradable and Biocompatible Nano-Objects from Polymerization-Induced and Crystallization-Driven Self-Assembly

Zhu, Chen; Nicolas, Julien

doi:10.1021/acs.biomac.2c00230

Cited by 31 publications

(41 citation statements)

References 192 publications

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“…Indeed, it requires a fine tuning of the chemistry by the RAFT process with the physicochemical aspects of the system. Considering the interest raised by PISA in the recent years, [22] this type of nanoparticles and the way to make them should be considered as additional useful tools for the design of vehicles for drug delivery or nanomedicine applications [4, 39, 40] …”

Section: Discussionmentioning

confidence: 99%

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RAFT‐Mediated Emulsion Polymerization‐Induced Self‐Assembly for the Synthesis of Core‐Degradable Waterborne Particles

et al. 2023

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Poly(N-acryloylmorpholine) (PNAM)-decorated waterborne nanoparticles comprising a core of either degradable polystyrene (PS) or poly(n-butyl acrylate) (PBA) were synthesized by polymerizationinduced self-assembly (PISA) in water. A PNAM bearing a trithiocarbonate chain end (PNAM-TTC) was extended via reversible addition-fragmentation chain transfer (RAFT)-mediated emulsion copolymerization of either styrene (S) or n-butyl acrylate (BA) with dibenzo[c,e]oxepane-5-thione (DOT). Well-defined amphiphilic block copolymers were obtained. The in situ self-assembly of these polymers resulted in the formation of stable nanoparticles. The insertion of thioester units in the vinylic blocks enabled their degradation under basic conditions. The same strategy was then applied to the emulsion copolymerization of BA with DOT using a poly(ethylene glycol) (PEG) equipped with a trithiocarbonate end group, resulting in PEGdecorated nanoparticles with degradable PBA-based cores.

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Section: Discussionmentioning

confidence: 99%

“…Considering the interest raised by PISA in the recent years, [22] this type of nanoparticles and the way to make them should be considered as additional useful tools for the design of vehicles for drug delivery or nanomedicine applications. [4,39,40]…”

Section: Conflict Of Interestmentioning

confidence: 99%

RAFT‐Mediated Emulsion Polymerization‐Induced Self‐Assembly for the Synthesis of Core‐Degradable Waterborne Particles

et al. 2023

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“…This is unfortunate since the polymerization-induced self-assembly (PISA) , of vinyl monomers has been established as a robust, versatile, and surfactant-free one-pot process to produce well-defined multiblock vinyl copolymer nanoparticles at high concentrations for a wide range of applications, spanning from Pickering emulsifiers and lubricants to nanoparticles for catalysis and biomedical applications. − Recent developments were also directed toward photo-PISA, , the tuning of the nanoparticle shape, , and the development of new PISA-based processes, , among other achievements. Conferring degradability to PISA systems has been recently reported by combining PISA and rROP (termed rROPISA). − However, to prevent the early degradation of CKAs, the polymerizations were performed in (non)polar aprotic solvents: (i) in heptane to generate organic dispersions of nanoparticles with CKA in the core and/or in the shell, and (ii) in DMF followed by transfer to water to produce aqueous dispersions of core-degradable nanoparticles via a two-step rROPISA process …”

Section: Introductionmentioning

confidence: 99%

Degradable Vinyl Copolymer Nanoparticles/Latexes by Aqueous Nitroxide-Mediated Polymerization-Induced Self-Assembly

et al. 2022

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The synthesis of degradable vinyl polymer nanoparticles/latexes in aqueous dispersed media is receiving much attention, particularly for biomedical applications and plastic pollution control, as it can circumvent the severe limitations associated with the emulsification of preformed degradable polymers. Polymerization-induced self-assembly (PISA), which enables the in situ formation of aqueous suspensions of diblock copolymer nano-objects of high solids content, has become a very popular polymerization process due to its many advantages in terms of simplicity, robustness, scalability, and versatility. However, the preparation of degradable vinyl polymer nanoparticles by direct aqueous PISA has never been reported. This severely limits the use of PISA in biomedical and environmental applications. Herein, we report the first aqueous emulsion PISA able to generate degradable vinyl polymer nanoparticles. It relies on radical ring-opening polymerization-induced self-assembly (rROPISA) of traditional vinyl monomers (n-butyl acrylate or styrene) with dibenzo[c,e]oxepane-5-thione (DOT), a thionolactone that features high stability in protic solvents and favorable reactivity with many vinyl monomers and is a precursor of labile thioester groups in the main chain. Stable aqueous suspensions of thioester-containing diblock copolymer nanoparticles were obtained with both vinyl monomers. Extensive degradation of the copolymers and the nanoparticles was successfully demonstrated under aminolytic or basic conditions. Given the success of the PISA process within the polymer community, this work has the potential to greatly expand its use in many areas, from nanomedicine (providing applicability to biocompatible vinyl polymers) to degradable coatings and sustained materials.

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“…Recent development in PISA techniques has allowed for the access to a variety of core-degradable diblock copolymer nanoparticles. 32,[98][99][100][101][102] For example, Nicolas group was able to integrate polycaprolactone-like degradable units into the polymer nanoparticle core by using cyclic ketene acetals as core-forming monomers in radical ROPISA. 98 It would be highly impactful to translate those novel PISA technique and core-forming monomers into the synthesis of next-generation biomolecule-polymer nanoparticles with biodegradable cores.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

“…To address this issue, biodegradable synthetic polymer materials should be considered for the future design of biomolecule‐polymer nanoparticles. Recent development in PISA techniques has allowed for the access to a variety of core‐degradable diblock copolymer nanoparticles 32,98–102 . For example, Nicolas group was able to integrate polycaprolactone‐like degradable units into the polymer nanoparticle core by using cyclic ketene acetals as core‐forming monomers in radical ROPISA 98 .…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Assembling the best of two worlds: Biomolecule‐polymer nanoparticles via polymerization‐induced self‐assembly

Shirinichi

Ibrahim

Rodriguez

et al. 2022

Journal of Polymer Science

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Biomolecule-polymer nanoparticles are recently emerging as a new class of biomolecule-polymer conjugates. They represent promising nanomaterials in a wide range of applications including but not limited to therapeutics, drug delivery systems, antimicrobial agents, sensors, and catalysis. In the past 5 years, there has been a significant effort applied to expand the family of biomolecule-polymer nanoparticles via polymerization-induced self-assembly (PISA) approach. Given the excellent functional group tolerance of PISA process which relies on controlled polymerization methods, a broad spectrum of biomolecules has been incorporated into polymer nanoparticles with various morphologies. In this mini-review, we will highlight the biomolecule-polymer nanoparticles that have been achieved by PISA approach, including (1) protein-polymer nanoparticles, (2) oligopeptide-polymer nanoparticles, (3) nucleic acid-polymer nanoparticles, as well as (4) polysaccharide-polymer nanoparticles. In addition, various PISA strategies based on different controlled polymerization methods will be covered. Potential applications, challenges, and future perspectives of this new library of biomolecule-polymer conjugates are discussed. It is clear from recent research in this field that PISA represents a powerful synthetic tool towards biomolecule-polymer nanoparticles with novel structures and properties previously inaccessible by other synthetic approaches.

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(Bio)degradable and Biocompatible Nano-Objects from Polymerization-Induced and Crystallization-Driven Self-Assembly

Cited by 31 publications

References 192 publications

RAFT‐Mediated Emulsion Polymerization‐Induced Self‐Assembly for the Synthesis of Core‐Degradable Waterborne Particles

RAFT‐Mediated Emulsion Polymerization‐Induced Self‐Assembly for the Synthesis of Core‐Degradable Waterborne Particles

Degradable Vinyl Copolymer Nanoparticles/Latexes by Aqueous Nitroxide-Mediated Polymerization-Induced Self-Assembly

Assembling the best of two worlds: Biomolecule‐polymer nanoparticles via polymerization‐induced self‐assembly

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