Synthesis and characterization of camptothecin-rhamnolipid-layered double hydroxide nanohybrid and its controlled release property

Li, Yan; Mao, Xiaoming; Liang, Yaqin

doi:10.1080/01932691.2019.1627880

Cited by 11 publications

(10 citation statements)

References 29 publications

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“…The fitting model was chosen according to the correlation coefficient (R 2 ) and rate constant. As illustrated in Figure 6, the correlation coefficient of the Bhaskar model was 0.9908, which was higher than that of the zero‐order (R 2 =0.6122), first‐order (R 2 =0.9542), and Hixson‐Crowell model (R 2 =0.6965), implying that the release of TPL can be divided into two steps: drug diffusion through the intraparticle and diffusion through the liquid around the particle, among which intraparticle diffusion is the rate‐controlling step [45] …”

Section: Resultsmentioning

confidence: 82%

“…As illustrated in Figure 6, the correlation coefficient of the Bhaskar model was 0.9908, which was higher than that of the zero-order (R 2 = 0.6122), first-order (R 2 = 0.9542), and Hixson-Crowell model (R 2 = 0.6965), implying that the release of TPL can be divided into two steps: drug diffusion through the intraparticle and diffusion through the liquid around the particle, among which intraparticle diffusion is the rate-controlling step. [45] Cytotoxicity assay MTS assay was performed to evaluate the cytotoxicity and antitumor activity of TPL@TSCD/MCC NPs, TSCD/MCC NPs, free TPL, and cisplatin were chosen as a control group. As illustrated in Figure 7a, after incubating BEAS-2B cells with 0.16, and 4.00 μg/mL of TPL, TSCD/MCC NPs, and TPL@TSCD/MCC, the cell viability of BEAS-2B cells showed a concentration-dependent decrease, while the relative cell viability of the TSCD/MCC NPs and TPL@TSCD/MCC groups was significantly higher than that of the free TPL group, showing that TSCD/MCC NPs displayed favorable biosafety as well as reduced the toxicity of…”

Section: Tpl Release Kineticsmentioning

confidence: 99%

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A Supramolecular Nanovehicle Featuring a pH/Enzyme Co‐Response for Targeted Delivery of the Antitumor Compound

et al. 2023

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Triptolide (TPL) has gained much attention as an antitumor compound with potential applications. However, TPL suffers from low bioavailability, severe toxic side effects, and limited targeted uptake by tumor cells, thus restricting the conversion of its clinical application. Here, a supramolecular nanovehicle, named TSCD/MCC NPs, featuring pH/AChE co-response was designed and prepared for loading, delivery, and targeted release of TPL. The cumulative release rate of TPL from TPL@TSCD/MCC NPs reached ~90 % within 60 h at pH 5.0 and AChE co-stimulation. Bhaskar model is used to study TPL release procedure. In cell experiments, TPL@TSCD/MCC NPs showed high toxicity to the four tumor cells lines A549, HL-60, MCF-7, and SW480, and favorable biosafety to normal cells BEAS-2B. Furthermore, TPL@TSCD/MCC NPs containing relatively small amounts of TPL presented similar apoptosis rates to those of intrinsic TPL. We anticipate that TPL@TSCD/MCC NPs may facilitate the conversion of TPL into clinical applications through further studies.

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Section: Resultsmentioning

confidence: 82%

Section: Tpl Release Kineticsmentioning

confidence: 99%

A Supramolecular Nanovehicle Featuring a pH/Enzyme Co‐Response for Targeted Delivery of the Antitumor Compound

et al. 2023

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“…(C) After incubation, the mixture was centrifuged at 3000 r min −1 for 5 min, photos were taken, and then 0.2 mL of supernatant was pipetted out into a 96 well plate, and the absorbance value at 545 nm was measured with a microplate reader. The hemolysis ratio (HR) was calculated using the following equation: 34 where D t , D nc , and D pc are the absorbance of the experimental sample, negative control group, and positive control group, respectively.…”

Section: Methodsmentioning

confidence: 99%

β-Cyclodextrin-based supramolecular nanoparticles: pH-sensitive nanocarriers for the sustained release of anti-tumor drugs

Yan²,

Jin

et al. 2022

New J. Chem.

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“…To study the mechanism of HCPT release from HCPT‐loaded NPs, the release data are fitted into different kinetic models, such as the pseudo‐first‐order model, pseudo‐second‐order model, Higuchi model, and Bhaskar model. The kinetic model equations are as follows 36 :…”

Section: Methodsmentioning

confidence: 99%

A dual‐stimuli responsive supramolecular nanovector anchoring folic acid ligands for targeted delivery of anti‐colorectal drug hydroxycamptothecin

Teng

Chen

et al. 2022

J of Applied Polymer Sci

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Hydroxycamptothecin (HCPT) is a first-line anti-colorectal cancer chemotherapeutic agent. Nevertheless, the poor tumor-specific delivery properties of HCPT make it indiscriminate in killing normal and cancer cells, as well as impossible to achieve sustained treatment due to its low cumulative concentration in cancer cells. Here, a pH and temperature co-responsive supramolecular nanocarrier anchoring with folic acid (FA) ligands, termed PEHA-β-CD-FA/SDS NPs, was prepared based on electrostatic interaction between cationic mono-(6-pentaethylenehexamine)-β-CD (PEHA-β-CD-FA) and anionic sodium dodecyl sulfate (SDS). PEHA-β-CD-FA/SDS NPs exhibited assembly/disassembly behavior accompanied by co-regulation of temperature and pH and are therefore employed as nanocarriers to load, deliver, and release HCPT. Notably, the release rate of HCPT achieved 93.6% at pH = 8.5 and T = 45 C which simulates the microenvironment of colon cancer cells. Cell biology experiments demonstrated that the more precise targeting ability of HCPT-loaded NPs resulted in higher cytotoxicity to tumor cells but also less toxicity to normal cells BEAS-2B. Flow cytometry apoptosis analysis also demonstrated that HCPT-loaded NPs had a significant growth-inhibitory effect on SW480 colon cancer cells. We expected that the supramolecular nanoparticles combining active and passive targeting capabilities could be further developed as potential drug carrier formulations for enhancing the clinical efficacy of anti-colon cancer drugs.

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Synthesis and characterization of camptothecin-rhamnolipid-layered double hydroxide nanohybrid and its controlled release property

Cited by 11 publications

References 29 publications

A Supramolecular Nanovehicle Featuring a pH/Enzyme Co‐Response for Targeted Delivery of the Antitumor Compound

A Supramolecular Nanovehicle Featuring a pH/Enzyme Co‐Response for Targeted Delivery of the Antitumor Compound

β-Cyclodextrin-based supramolecular nanoparticles: pH-sensitive nanocarriers for the sustained release of anti-tumor drugs

A dual‐stimuli responsive supramolecular nanovector anchoring folic acid ligands for targeted delivery of anti‐colorectal drug hydroxycamptothecin

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