β-Cyclodextrin-based supramolecular nanoparticles: pH-sensitive nanocarriers for the sustained release of anti-tumor drugs

Abstract

Chemotherapy is one of the effective ways to treat cancer because of its ability to control lesions quickly. However, chemotherapy can have many side effects due to chemotherapy indiscriminately...

A temperature-sensitive HA-anchoring supramolecular nanocarrier for targeted delivery of the anti-liver cancer drug doxorubicin

“…17 Our team constructed a pH stimulus-responsive nanocarrier based on modified β-CD and cetyl benzyldimethylammonium chloride for loading the drug celastrol (CSL). 18 At the same time, we also prepared a pH stimulus-responsive nanocarrier based on carboxylated cyclodextrin for loading the anti-colon cancer drug CSL. 19 While single stimulus-responsive supramolecular nanocarriers have been the subject of widespread research, the internal environment of tumor tissues and cells is complex, and a single stimulus-responsive mechanism may not suffice for targeted and controlled drug delivery.…”

“…Cyclodextrins (CDs) are cyclic oligosaccharides that usually contain 6–12 d -glucopyrane units. 18 Due to their unique structure and biocompatibility, they are versatile host molecules for building stimulus-responsive supramolecular nanocarriers through various noncovalent interactions. Hyaluronic acid (HA) is an acidic polysaccharide that is an important part of human tissues, and its unique molecular structure and physicochemical properties endow it with unique physiological functions.…”

Different Drug Mobilities in Hydrophobic Cavities of Host–Guest Complexes between β-Cyclodextrin and 5-Fluorouracil at Different Stoichiometries: A Molecular Dynamics Study in Water

“…Cyclodextrins and materials containing cyclodextrins are likely to find increasing usage in a growing diversity of pharmaceutical applications, most notably those involving macromolecular therapeutics, as an interesting family of cage molecules [ 7 , 8 , 9 ]. Cyclodextrins, as drug delivery systems, have been extensively studied according to differences in the drug therapeutic environment, such as the pH, light, temperature, redox, and enzymes [ 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 ]. Native cyclodextrins and chemically functionalized CDs are smart tools that have been proven to be effective for use in the preparation of drug delivery systems, becoming a new area of research in recent years due to their ability to form stable host–guest inclusion complexes with poorly soluble drugs by encapsulating them in their hydrophobic cavities or interacting with them at the outer surface [ 19 , 20 , 21 , 22 ].…”

A Supramolecular Nanovehicle Featuring a pH/Enzyme Co‐Response for Targeted Delivery of the Antitumor Compound

“…[27] Since supramolecular nanocarriers are assemblies formed by non-covalent interactions between host and guest, such as hydrogen bonds, van der Waals forces, hydrophobic interactions, electrostatic interactions, etc., they can easily respond to external stimuli such as temperature, pH, light, magnetism, enzymes, redox, or even their combinations, and further release the cargo loading in the chamber of nanocarriers. [28][29][30][31][32][33][34] Cyclodextrins (CDs) are a class of natural supramolecular hosts that are favorable build blocks for designing nanocarriers. [35][36][37] For instance, Xue et al prepared a new type of pH-responsive nanogel by using hydrazide-modified CMC and aldehyde-modified β-CD, which could encapsulate the hydrophobic drug CK, control its release, and enhance its anticancer activity.…”