Synthesis and characterization of Bodipy functionalized magnetic iron oxide nanoparticles for potential bioimaging applications

Topel, Seda Demirel; Topel, Önder; Bostancıoğlu, Rakibe Beklem; Koparal, Ayşe Tansu

doi:10.1016/j.colsurfb.2015.01.043

Cited by 36 publications

(28 citation statements)

References 36 publications

(36 reference statements)

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“…performed a modified coprecipitation method to produced functionalized polyethyleneimine (PEI) coated Fe 3 O 4 nanoparticles, with a diameter of around 10 nm, covalently conjugated with fluorophore molecules. [72] Their investigation from in vitro tests on two human cancer cells showed the easy penetration of the resultant MNPs into cell cytoplasm in the living cells to be very promising for bio-imaging applications. In a very recent study performed by Bhandari et al, [73] a simple coprecipitation method was used to produce curcumin functionalized magnetite nanoparticles and they were analyzed for cell viability assay against an inflammatory agent.…”

Section: Coprecipitationmentioning

confidence: 99%

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Mosayebi

Kiyasatfar

Laurent

2017

Adv Healthcare Materials

187

171

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In order to translate nanotechnology into medical practice, magnetic nanoparticles (MNPs) have been presented as a class of non‐invasive nanomaterials for numerous biomedical applications. In particular, MNPs have opened a door for simultaneous diagnosis and brisk treatment of diseases in the form of theranostic agents. This review highlights the recent advances in preparation and utilization of MNPs from the synthesis and functionalization steps to the final design consideration in evading the body immune system for therapeutic and diagnostic applications with addressing the most recent examples of the literature in each section. This study provides a conceptual framework of a wide range of synthetic routes classified mainly as wet chemistry, state‐of‐the‐art microfluidic reactors, and biogenic routes, along with the most popular coating materials to stabilize resultant MNPs. Additionally, key aspects of prolonging the half‐life of MNPs via overcoming the sequential biological barriers are covered through unraveling the biophysical interactions at the bio–nano interface and giving a set of criteria to efficiently modulate MNPs' physicochemical properties. Furthermore, concepts of passive and active targeting for successful cell internalization, by respectively exploiting the unique properties of cancers and novel targeting ligands are described in detail. Finally, this study extensively covers the recent developments in magnetic drug targeting and hyperthermia as therapeutic applications of MNPs. In addition, multi‐modal imaging via fusion of magnetic resonance imaging, and also innovative magnetic particle imaging with other imaging techniques for early diagnosis of diseases are extensively provided.

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Section: Coprecipitationmentioning

confidence: 99%

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Mosayebi

Kiyasatfar

Laurent

2017

Adv Healthcare Materials

187

171

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“…To eliminate this unwanted process, coating with a biocompatible shell, such as a polymer [92], ceramics [93] or metals [13], is needed in order to prevent conglomeration. In addition, iron oxide NPs can be functionalized with proteins, antibodies, enzymes and anticancer drugs [13] and are investigated for different applications including magnetic hyperthermia [94], contrast agents in MRI (magnetic resonance imaging) [95], targeted drug delivery [96], multimodal imaging and gene therapy [61].…”

Section: Classification Of Npsmentioning

confidence: 99%

Theranostic Nanoparticles and Their Spectrum in Cancer

Onaciu¹,

Jurj²,

Moldovan³

et al. 2020

Engineered Nanomaterials - Health and Safety

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Nanoparticles offer a lot of advantageous backgrounds for many applications due to their physical, chemical and biological properties. Their different composition (metals, lipids, polymers, peptides) and shapes (spheres, rods, pyramids, flowers and so on) are influenced by the synthesis methods and functionalization procedures. However, in the medical field, researchers focus on the biocompatibility and biodegradability of the nanoparticles in their attempts for a targeted therapy in which the nanocarriers need to bypass certain biological barriers. Moreover, the increased interest in molecular imaging has brought nanoparticles in the spotlight for their applications in two distinct directions: therapy and diagnosis. Furthermore, recent advances in nanoparticle designs have introduced novel nano-objects suitable as both detection and delivery systems at the same time, thus providing theranostic applications.

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“…Magnetic NPs can be functionalized with different kinds of biomolecules such as antibodies, oligonucleotides, carbohydrates or enzymes, depending on the targeted application. However, other ligands with additional physico‐chemical properties such as redox probes, fluorescent dyes,, gold colloids, or quantum dots, can also be immobilized onto magnetic NPs.…”

Section: Introductionmentioning

confidence: 99%

Polyamidoamine Dendrimers as Crosslinkers for Efficient Electron Transfer between Redox Probes onto Magnetic Nanoparticles

et al. 2018

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The efficient conjugation of ferrocenecarboxylic acid (Fc), a usual electroactive probe, onto COOH‐modified magnetic nanoparticles (NPs) is reported. Amine crosslinkers were used to couple COOH groups from NPs and from Fc. The coupling efficiencies using different generations of polyamidoamine (PAMAM) dendrimer and ethylenediamine (EDA) were compared through zeta potential measurements, square‐wave voltammetry (SWV) and NH2 titration. Highest PAMAM generations led to NH2‐modified NPs with increased zeta potential and NH2 density compared to lowest ones. Moreover, no aggregation was observed after crosslinker grafting. SWV was applied to characterize Fc‐modified NPs. PAMAM generations 0–3 improved the electrochemical signal in comparison to EDA. However, increasing PAMAM generations led to NPs aggregation. Quantitative results supported the fact that PAMAM generation 0 was the best compromise for large electrochemical signal without NPs aggregation.

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Synthesis and characterization of Bodipy functionalized magnetic iron oxide nanoparticles for potential bioimaging applications

Cited by 36 publications

References 36 publications

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Theranostic Nanoparticles and Their Spectrum in Cancer

Polyamidoamine Dendrimers as Crosslinkers for Efficient Electron Transfer between Redox Probes onto Magnetic Nanoparticles

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