Synthesis and characterization of arginine-NIPAAm hybrid hydrogel as wound dressing: In vitro and in vivo study

Wu, Dequn; Zhu, Jing; Han, Hua; Zhang, Junzhi; Wu, Feifei; Qin, Xiaohong; Yu, Jianyong

doi:10.1016/j.actbio.2017.08.048

Cited by 111 publications

(87 citation statements)

References 48 publications

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“…The biomedical application of hydrogel began at the 1960s (first used for contact lens) and have since been applied as drug delivery, wound dressing, tissue scaffold, and body implant . In these applications, implant and artificial tissue are the preferred applications of high‐strength hydrogels.…”

Section: Applicationsmentioning

confidence: 99%

High‐strength hydrogels: Microstructure design, characterization and applications

Hua

Fei

2018

J Polym Sci B Polym Phys

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Hydrogels are a class of polymeric network materials embedded in a water-rich environment. They are widely applied in drug delivery, actuator, and sensor. However, conventional hydrogels encountered limits from their poor mechanical property. Recent researches in hydrogels have been focusing on mechanical enhancement, ranging from design of microstructures to adjustment of compositions in hydrogels. Here, the design and fabrication strategies of high-strength hydrogels, as well as major progress in their typical strength-support applications are systemically reviewed.

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Section: Applicationsmentioning

confidence: 99%

High‐strength hydrogels: Microstructure design, characterization and applications

Hua

Fei

2018

J Polym Sci B Polym Phys

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“…PNIPAAm has been used for smart materials, which mainly utilizes surface property changes and volume phase transitions with response to ambient temperature. The versatility of PNIPAAm has led to finding uses in cell culture [4], tissue engineering [5], enzymatic immobilization [6], drug delivery [7], wound dressing [8], biosensors [9], etc. One of the most important applications of PNIPAAm is cell culture.…”

Section: Preparation Of Pnipaam Medicated Substrates For Cell Culturementioning

confidence: 99%

Preparation and Characterization of Thermoresponsive Poly(N-Isopropylacrylamide) for Cell Culture Applications

et al. 2020

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Poly(N-isopropylacrylamide) (PNIPAAm) is a typical thermoresponsive polymer used widely and studied deeply in smart materials, which is attractive and valuable owing to its reversible and remote "on-off" behavior adjusted by temperature variation. PNIPAAm usually exhibits opposite solubility or wettability across lower critical solution temperature (LCST), and it is readily functionalized making it available in extensive applications. Cell culture is one of the most prospective and representative applications. Active attachment and spontaneous detachment of targeted cells are easily tunable by surface wettability changes and volume phase transitions of PNIPAAm modified substrates with respect to ambient temperature. The thermoresponsive culture platforms and matching thermal-liftoff method can effectively substitute for the traditional cell harvesting ways like enzymatic hydrolysis and mechanical scraping, and will improve the stable and high quality of recovered cells. Therefore, the establishment and detection on PNIPAAm based culture systems are of particular importance. This review covers the important developments and recommendations for future work of the preparation and characterization of temperature-responsive substrates based on PNIPAAm and analogues for cell culture applications.

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“…Moreover, some types of hydrogels exhibit specific outstanding characteristics, such as good biocompatibility, biodegradation, tunable mechanical properties, and good elasticity . Therefore, they are widely applied in the biomedical studies, such as tissue engineering, drug/gene vehicles, and wound dressing …”

Section: Introductionmentioning

confidence: 99%

Hydrogels based on chitosan in tissue regeneration: How do they work? A mini review

Jiao

Huang

Zhang

2018

J of Applied Polymer Sci

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The repair of tissue defects after injury is of significant clinical and research importance. A variety of chitosan‐based hydrogels have been investigated and applied to address this problem. By using different synthetic methods, the hydrogels exhibit distinct physical properties, including porosity, adhesion, and stiffness. These properties are considered important factors affecting cell proliferation and tissue regeneration. Meanwhile, drug delivery and cell delivery are the two main strategies to improve the therapeutic effects of chitosan‐based hydrogels, but the choices of cells or drugs are quite varied and largely depend on the specificity of the treated tissues. The present review summarizes the physicochemical properties of chitosan‐based hydrogels and their influences on cells, and lists specific ways to promote the tissue regeneration in different systems of the human body. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47235.

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Synthesis and characterization of arginine-NIPAAm hybrid hydrogel as wound dressing: In vitro and in vivo study

Cited by 111 publications

References 48 publications

High‐strength hydrogels: Microstructure design, characterization and applications

High‐strength hydrogels: Microstructure design, characterization and applications

Preparation and Characterization of Thermoresponsive Poly(N-Isopropylacrylamide) for Cell Culture Applications

Hydrogels based on chitosan in tissue regeneration: How do they work? A mini review

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