Synthesis and characterization of antibacterial 2-(pyridin-3-yl)-1H-benzo[d]imidazoles and 2-(pyridin-3-yl)-3H-imidazo[4,5-b]pyridine derivatives

Mallemula, Venkata Ramakrishna; Sanghai, Niraj Nemichand; Himabindu, V.; Chakravarthy, A. Kalyan

doi:10.1007/s11164-013-1335-5

Cited by 18 publications

(8 citation statements)

References 31 publications

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“…All the samples show antifungal activity against C. The results further confirmed that triazole groups grafted into the synthesized chitosan derivatives contribute a lot to the antifungal action and consequently increase the antifungal activity of them. The triazole groups could inhibit synthesis of the cell membrane and cell wall to exhibit antimicrobial activity [39]. At the same time, the inhibitory index of TCTS with DS of 0.86% was slightly inferior to that of CTCTS with DS of 0.78 and BTCTS with DS of 0.82, suggesting that a higher inhibitory index of CTCTS and BTCTS should be possible if TCTS, CTCTS, and BTCTS have the same DS.…”

Section: Water Solubility and Antifungal Activitymentioning

confidence: 99%

Synthesis of water soluble chitosan derivatives with halogeno-1,2,3-triazole and their antifungal activity

Tan

Zhang

et al. 2016

International Journal of Biological Macromolecules

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a b s t r a c tChitosan is an abundant and renewable polysaccharide, which exhibits attractive bioactivities and natural properties. Improvement such as chemical modification of chitosan is often performed prior to further utilization. Three novel water soluble chitosan derivatives containing 1,2,3-triazole with or without halogen was designed and synthesized. Their antifungal activity against three kinds of phytopathogens was estimated by hyphal measurement in vitro. The inhibitory property and water solubility of the synthesized chitosan derivatives exhibited a remarkable improvement over chitosan. It is hypothesized that thiazolyl groups enable the synthesized chitosan to possess obviously better antifungal activity. Moreover, CTCTS and BTCTS, which have halogens at the periphery of polymers, inhibited the growth of tested phytopathogens more effectively with inhibitory indices of 81-93% at 1.0 mg/mL. The halogens could have a synergistic effect with triazole as they exhibited antifungal activity and electron-withdrawing capacity, which improve the antifungal activity of chitosan derivatives.

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Section: Water Solubility and Antifungal Activitymentioning

confidence: 99%

Synthesis of water soluble chitosan derivatives with halogeno-1,2,3-triazole and their antifungal activity

Tan

Zhang

et al. 2016

International Journal of Biological Macromolecules

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“…The antibacterial activity of successive extracts was performed using agar cup-plate method (Mallemula et al, 2013). Twenty milliliter of the sterile nutrient agar medium was poured into sterile Petri-dishes and allowed to solidify.…”

Section: Anti-microbial Activitymentioning

confidence: 99%

In vitro Antimicrobial Activity of Extracts from Careya arborea Roxb Leaves

Mali¹,

Wadje²

2014

Microbiology J.

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Antimicrobial activity of Careya arborea Roxb., leaf extracts was determined using cup-plate diffusion, two-fold serial dilution method. In cup-plate method, inhibition zone sizes were used to determine the susceptibility to extracts. The results showed that C. arborea leaf extracts showed potential antibacterial activity against S. aureus and B. subtilis. Ethyl acetate and ethanol extracts showed the highest zones of inhibition for Gram positive and Gram negative bacteria and for fungus C. albicans. Careya arborea leaf extracts were able to have a MIC range of 0.938-15 mg mLG , in two-fold dilution method. The ethylacetate extract exhibited significantly 1 better inhibition compared to other extracts. Gram-positive B. subtilis, Gram-negative E. coli and fungus C. albicans were found to be most susceptible to ethylacetate extract. The extracts have shown to be bacteriostatic and fungistatic at low concentrations. Phytochemical screening of the extracts revealed the presence of phyto-compounds such as triterpenoids, steroids, flavonoids and tannins as major phytoconstituents with known antimicrobial agents. These phyto-constituents may be responsible for the antimicrobial activity of C. arborea.

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“…It is known that 1,2,3-triazoles are antimicrobial agents per se, because they can inhibit synthesis of the cell membrane, cell wall, and nucleic acids of bacteria [35]. The antimicrobial action is generally caused by ionic and hydrophobic interactions between the biocide and the outer phospholipid membrane of the microorganism [40].…”

Section: Antimicrobial Activitymentioning

confidence: 99%

Hydrophobically Modified Dextran Esters as Potential External Biocides

TUCHILUS¹

2022

FARMACIA

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Amphiphilic dextran-based esters were synthesized by coupling several disubstituted 1,2,3-triazole derivatives on the polysaccharide. The polymers were characterized by elemental analysis and spectroscopy measurements: X-ray photoelectron (XPS), Fourier transform infrared (FTIR), carbon-13 nuclear magnetic resonance ( 13 C NMR). Triazole derivatives and their corresponding dextran esters showed a moderate to good antimicrobial activity, the antifungal activity being stronger than the antibacterial one. Halogenated polymers proved to be potential external biocides due to their both bactericidal and fungicidal activity. RezumatEsterii amfifili bazați pe dextrani au fost sintetizați prin cuplarea pe polizaharida a mai multor derivați disubstituiți ai 1,2,3triazolului. Polimerii au fost caracterizați prin analiza elementală și măsurători spectroscopice (de fotoelectroni cu raze X -XPS, în infraroșu cu transformată Fourier -FTIR, rezonanță magnetică nucleară carbon-13 -13 C RMN). Derivații de triazol și esterii dextranului corespunzători au prezentat o activitate antimicrobiană moderată spre bună, activitatea antifungică fiind mai puternică decât cea antibacteriană. Polimerii halogenați s-au dovedit a fi produse potențiale biocide externe datorită activității lor bactericide și fungicide.

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Synthesis and characterization of antibacterial 2-(pyridin-3-yl)-1H-benzo[d]imidazoles and 2-(pyridin-3-yl)-3H-imidazo[4,5-b]pyridine derivatives

Cited by 18 publications

References 31 publications

Synthesis of water soluble chitosan derivatives with halogeno-1,2,3-triazole and their antifungal activity

Synthesis of water soluble chitosan derivatives with halogeno-1,2,3-triazole and their antifungal activity

In vitro Antimicrobial Activity of Extracts from Careya arborea Roxb Leaves

Hydrophobically Modified Dextran Esters as Potential External Biocides

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