Synthesis and Characterization of Acylated Low Molecular Weight Chitosan and Acylated Low Molecular Weight Phthaloyl Chitosan

Permadi, Rahadian; Suk, Vicit Rizal Eh; Misran, Misni

doi:10.17576/jsm-2020-4909-22

Cited by 3 publications

(2 citation statements)

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“…Chitosan has a more sloughy structure, and the synthesized product is a more flaky/sheet-like structure. CS is more porous than CM-CS. , From this FESEM study, it may be inferred that the carboxymethylation of chitosan is successfully done.…”

Section: Resultsmentioning

confidence: 99%

Development of a High-Performance Drilling Fluid Additive for Application in Indian Shale Gas Formations

et al. 2023

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With increasing energy demand, it has become pertinent to develop high-performing drilling fluids and additives with environmental compatibility for troublesome shale gas formations. In this research work, carboxymethyl chitosan (CM-CS) was synthesized using carboxymethylation reactions and characterized using advanced analytical techniques. The synthesized CM-CS was used as an additive in a water-based drilling fluid system comprising clay, carboxymethyl cellulose, polyanionic cellulose, and xanthan gum. The experimental investigation results of the drilling fluid properties, including the filtration and rheological tests, showed improvement compared with poly-(ethylene glycol) (PEG), a conventional shale inhibitor. At 0.3, 0.6, and 0.9 (w/v%) CM-CS, the filtrate loss was reduced by 38.75, 50, and 53.12% in comparison to the base fluid. Other tests included ζ-potential and shale recovery tests. The ζ-potential was used to determine the suspension stability of the drilling fluid. Shale recovery tests were conducted to assess the effectiveness of the fluid to address the wellbore instability issues for the chosen shale samples. The primary shale recovery percentages of CM-CS and PEG in drilling fluids were compared. Results show that the primary recovery factors increased by 32.42, 33.81, and 34.12 (wt%) when 0.3, 0.6, and 0.9 (w/v%) CM-CS was used as an additive. CM-CS shows minimum interaction of the fluid with the Indian shale samples based on shale recovery tests and filtration studies, which suggests that it can be better suited for the drilling fluid application in troublesome shale gas formation.

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Section: Resultsmentioning

confidence: 99%

Development of a High-Performance Drilling Fluid Additive for Application in Indian Shale Gas Formations

et al. 2023

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“…Completely deacetylated CS polymer reacted by phthalic anhydride yields N-phthaloyl CS derivative which has a high solubility in polar-organic solvents [19]. Permadi et al [30] acylated a CS protected with phthalic anhydride (N-phtaloylated CS) and unprotected CS (without phthalic anhydride) via acylation on both primary hydroxyl and amine groups on the backbone of CS. This chemically modified CS was proposed to enhance the drug solubilization as well as improving biocompatibility and degradability.…”

Section: Chitosan Derivative Groups/derivatives Formulamentioning

confidence: 99%

Advances in Chitosan-Based Nanoparticles for Drug Delivery

Mikušová

Mikuš

2021

IJMS

196

120

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Nanoparticles (NPs) have an outstanding position in pharmaceutical, biological, and medical disciplines. Polymeric NPs based on chitosan (CS) can act as excellent drug carriers because of some intrinsic beneficial properties including biocompatibility, biodegradability, non-toxicity, bioactivity, easy preparation, and targeting specificity. Drug transport and release from CS-based particulate systems depend on the extent of cross-linking, morphology, size, and density of the particulate system, as well as physicochemical properties of the drug. All these aspects have to be considered when developing new CS-based NPs as potential drug delivery systems. This comprehensive review is summarizing and discussing recent advances in CS-based NPs being developed and examined for drug delivery. From this point of view, an enhancement of CS properties by its modification is presented. An enhancement in drug delivery by CS NPs is discussed in detail focusing on (i) a brief summarization of basic characteristics of CS NPs, (ii) a categorization of preparation procedures used for CS NPs involving also recent improvements in production schemes of conventional as well as novel CS NPs, (iii) a categorization and evaluation of CS-based-nanocomposites involving their production schemes with organic polymers and inorganic material, and (iv) very recent implementations of CS NPs and nanocomposites in drug delivery.

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Biomedical Applications of Carbohydrate-based Polyurethane: From Biosynthesis to Degradation

Batool

Rehman

Qader

et al. 2022

CPD

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The foremost common natural polymers are carbohydrate-based polymers or polysaccharides, having a long chain of monosaccharide or disaccharide units linked together via a glycosidic linkage to form a complex structure. There are several uses of carbohydrate-based polymers in biomedical sector due to its attractive features including less toxicity, biocompatibility, biodegradability, high reactivity, availability, and relatively inexpensive. The aim of our study was to explore the synthetic approaches for the preparation of numerous carbohydrate-based polyurethanes (PUs) and their wide range of pharmaceutical and biomedical applications. The data summarized in this study shows that the addition of carbohydrates in the structural skeleton of PUs not only improve their suitability but also effect the applicability for employing them in biological applications. Carbohydrate-based units are incorporated into the PUs, which is the most convenient method for the synthesis of novel biocompatible and biodegradable carbohydrate-based PUs to use in various biomedical applications.

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Synthesis and Characterization of Acylated Low Molecular Weight Chitosan and Acylated Low Molecular Weight Phthaloyl Chitosan

Cited by 3 publications

References 0 publications

Development of a High-Performance Drilling Fluid Additive for Application in Indian Shale Gas Formations

Development of a High-Performance Drilling Fluid Additive for Application in Indian Shale Gas Formations

Advances in Chitosan-Based Nanoparticles for Drug Delivery

Biomedical Applications of Carbohydrate-based Polyurethane: From Biosynthesis to Degradation

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