“…Many of the conventional devices and techniques, including nuclear magnetic resonance [178] , surface plasmon resonance [179] and mass spectrometry [180] , however, requiring time -consuming purifi cation of samples, may lack the ability for multiplexed measurements that are desirable in identifying complex diseases, or may be uncontrollable for easy point -of -care translation [3,175] . In contrast, biosensors enable direct, sensitive, selective, and rapid analysis of biological and chemical species, and thus are widely used in many areas of healthcare and life sciences, ranging from uncovering and diagnosing disease to the discovery and screening of new drugs and biomolecules [20,181,182] . For example, in brain monitoring, l -glutamate is the most widespread excitatory neurotransmitter in the mammalian central nervous system, plays a important role in a broad range of brain functions, and has been implicated in a number of neurological disorders [33,183] .…”