Synthesis and characterization of [4-(2,4-dichlorophenoxybutyrate)-zinc layered hydroxide] nanohybrid

Abstract

A new layered organic-inorganic nanohybrid material in which an agrochemical, 4-(2,4dichlorophenoxy)butyrate (DPBA) is intercalated into inorganic interlayers of zinclayeredhydroxide (ZLH) was synthesized by direct reaction of aqueous DPBA solution with zinc oxide. The resulting nanohybrid is composed of the organic moieties, DPBA sandwiched between ZLH inorganic interlayers. The nanohybrid afforded well ordered crystalline layered structure, a basal spacing of 29.6 Å, 23.5% carbon (w/w) and 47.9% (w/w) loading of DPBA. FTIR study shows that the absorption bands of the resulting nanohybrid composed the FTIR characteristics of both the DPBA and ZLH which further confirmed the intercalation episode. The intercalated organic moiety in the form of nanohybrid is thermally more stable than its sodium salt. Scanning electron micrograph shows the ZnO precursor has very fine granular structure and transformed into a flake-like when the nanohybrid is formed. This work shows that the nanohybrid of DPBA-ZLH can be synthesized using simple, direct reaction of ZnO and DPBA under aqueous environment for the formation of a new generation of agrochemical.

Preparation of Fe3O4 magnetic nanoparticles coated with gallic acid for drug delivery

“…It is clear that an ideal level of pH in the blood is about 7.4, and even changing this level slightly may have fatal consequences. Therefore, release of gallic acid from nanoparticles was determined using a 0.0001 M aqueous solution of Na 2 CO 3 32 and Na 3 PO 4 buffered solutions of pH 4.8 [33][34][35][36][37][38][39] and 7.4 37,38,40,41 at 37°C. The gallic acid released was measured at preset times using ultraviolet-visible spectrophotometry at 264 nm.…”

Controlled-release formulation of antihistamine based on cetirizine zinc-layered hydroxide nanocomposites and its effect on histamine release from basophilic leukemia (RBL-2H3) cells

“…The release of cetirizine from CETN into the medium of phosphate buffer solution at pH 7.4 and pH 4.8 [22][23][24] was achieved by adding about 85 mg of CETN into 250 mL buffer solutions. The accumulated amount of cetirizine released into the solutions was measured at different times using a UV-visible spectrophotometer at 231 nm.…”

“…Release profiles for cetirizine from CETN ( Figure 7I) show results similar to those of other drugs, such as 5-flurouracil, camptothecin, naproxen, l-Dopa, and 5-florocytosine, found in the literature. 22,24,[35][36][37][38] Release kinetics of cetirizine from CETN In order to better understand the mechanism of the release of cetirizine from CETN, the results of the kinetic studies were analyzed using pseudo-first order (Equation 1), 39 pseudo-second order (Equation 2), 40 ln (q e −q t ) = ln q e − k 1 t…”

Development of antiproliferative nanohybrid compound with controlled release property using ellagic acid as the active agent

“…However, to the best of our knowledge, little work has been published on the use of ZnO as a starting material to intercalate drug actives. 35,36 Therefore, the main objective of this work was to explore the potential use of ZnO as a starting material for the intercalation of EA for the formation of a new EA-ZLH nanohybrid (EAN). The resulting nanohybrid was then used as a controlled release formulation of drug active EA.…”

“…Total disappearance of the intense peaks of ZnO phase indicated that the sample EAN is pure phase and the ZnO was completely converted to ZLH. 36 The formation of EAN is believed to occur through a dissociation-deposition mechanism 36,49 which takes place in the nonaqueous solution of hydrated EA. The mechanism is composed of three steps: …”