Synthesis and Characterization of 2-Alkylcarbamato -1,2,3,4 - Tetrahydro-1,3,2-Benzodiazaphosphorine 2-Oxides

Rao, L. Nagaprasada; Reddy, C. Devendranath; Raju, C. Naga

doi:10.1515/hc.2000.6.5.431

Cited by 5 publications

(1 citation statement)

References 2 publications

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“…• C under inert anhydrous conditions in dry toluene to afford the corresponding chlorides of carbamidophosphoric acids (3a-j) [11,12]. The reaction products separated from the reaction mixture immediately as crystalline compounds, after complete addition of amines.…”

Section: Resultsmentioning

confidence: 99%

Synthesis and antimicrobial activity of N‐substituted N′‐[6‐methyl‐2‐oxido‐1,3,2‐dioxaphosphinino(5,4‐b)pyridine‐2‐yl]ureas

Reddy

Venugopal

2003

Heteroatom Chemistry

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N‐Substituted N′‐[6‐methyl‐2‐oxido‐1,3,2‐dioxaphosphinino(5,4,‐b)pyridine‐2‐yl]ureas have been accomplished by condensation of equimolar quantities of chlorides of various carbamidophosphoric acids (3) with 3‐hydroxyl‐6‐methyl‐2‐pyridinemethanol (lutidine diol) (4) in the presence of triethylamine in dry toluene–tetrahydrofuran (1:1) mixture at 45–50°C. Their structures were established by elemental analyses, IR, 1H NMR, 13C NMR, and 31P NMR spectral data. Their antifungal and antibacterial activity is also evaluated. Most of these compounds exhibited moderate antimicrobial activity in the assays. © 2003 Wiley Periodicals, Inc. Heteroatom Chem 14:509–512, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.10181

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Section: Resultsmentioning

confidence: 99%

Synthesis and antimicrobial activity of N‐substituted N′‐[6‐methyl‐2‐oxido‐1,3,2‐dioxaphosphinino(5,4‐b)pyridine‐2‐yl]ureas

Reddy

Venugopal

2003

Heteroatom Chemistry

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Synthesis and antimicrobial activity of novel 2‐alkyl/arylcarbamato‐6‐(1,1‐dimethylethyl)‐3‐cyclohexyl‐3,4‐dihydro‐2H‐1,3,2‐benzoxazaphosphorine‐2‐oxides

Babu

Reddy

et al. 2002

Journal of Heterocyclic Chem

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Novel 2-alkyl/arylcarbamato-6-(1,1-dimethylethyl)-3-cyclohexyl-3,4-dihydro-2H-1,3,2-benzoxazaphosphorine-2-oxides (IV) have been synthesized from reactions of 2-cyclohexylaminomethyl-4-t-butylphenol I [8c] with various dichlorophosphinyl carbamates (III) [8a-b] in dry toluene in the presence of triethylamine at 40-50 °C. All the title compounds (IVa-j) at reflux temperature are degraded to 2-amino-6-(1,1-dimethylethyl)-3-cyclohexyl-3,4-dihydro-2H-1,3,2-benzoxazaphosphorine-2-oxide (IVk) exclusively. The structures are determined by ir, nmr and mass spectral studies. They were screened for antifungal activity against Penicillium notatum, Aspergillus niger and Helminthosporium sps, and antibacterial activity on Escherchia coli, Staphylococcus aureus and Pseudomonas aeruginosa. A few of them possess significant activity.

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Nuclear magnetic resonance data of C12H18N3O2PS

Jain

2010

Chemical Shifts and Coupling Constants for Hydrogen-1, Heterocycles

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Synthesis and Characterization of 2-Alkylcarbamato -1,2,3,4 - Tetrahydro-1,3,2-Benzodiazaphosphorine 2-Oxides

Cited by 5 publications

References 2 publications

Synthesis and antimicrobial activity of N‐substituted N′‐[6‐methyl‐2‐oxido‐1,3,2‐dioxaphosphinino(5,4‐b)pyridine‐2‐yl]ureas

Synthesis and antimicrobial activity of N‐substituted N′‐[6‐methyl‐2‐oxido‐1,3,2‐dioxaphosphinino(5,4‐b)pyridine‐2‐yl]ureas

Synthesis and antimicrobial activity of novel 2‐alkyl/arylcarbamato‐6‐(1,1‐dimethylethyl)‐3‐cyclohexyl‐3,4‐dihydro‐2H‐1,3,2‐benzoxazaphosphorine‐2‐oxides

Nuclear magnetic resonance data of C12H18N3O2PS

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