Synthesis and characterization of 159 Gd-doped hydroxyapatite nanorods for bioapplications as theranostic systems

89Sr‐doped hydroxyapatite nanoparticles as a potential therapeutic agent for bone tumors

“…20 Finally, it is possible to notice that all the samples presented the characteristic transmittance bands of the matrix material, indicating that the presence of Sr in the system does not alter the formation of HA. 20 Finally, it is possible to notice that all the samples presented the characteristic transmittance bands of the matrix material, indicating that the presence of Sr in the system does not alter the formation of HA.…”

“…22 The bands related to the stretching of the hydroxyl group (OH − ) can be observed at 3575 and 630 cm −1 , 21 and they gradually decrease while the Sr concentration increases. 20 The bands observed in 1419 and 1471 cm −1 can be attributed to the presence of carbonate ions (CO 3 2− ), suggesting the formation of carbonated HA. Consequently, this behavior will lead to disturbance of its vibrational mode, leading to a decrease in transmittance signal.…”

Nanotechnologies for early diagnosis, in situ disease monitoring, and prevention

“…One exception has been the use of commercially available Novasome 7474 (Novavax, Gaithersburg, Maryland, USA and IGI Laboratories, Buena, New Jersey, USA) for the vaginal delivery of −2 RANTES, a truncated fragment of Regulated on Activation, Normal T Expressed and Secreted (RANTES) chemokine presenting high specificity for CCR5 binding. 95,96 Novasome are 200-700 nm nonphospholipidic liposomes comprising monoesters of PEO fatty acids, cholesterol, and free fatty acids. 97 The association of −2 RANTES with Novasome did not affect the native activity of the protein.…”

“…97 The association of −2 RANTES with Novasome did not affect the native activity of the protein. 95,96 Data from an initial study by Kish-Catalone et al 95 were able to indicate that −2 RANTES/ liposome complexes elicited only mild signs of inflammation when administered to mice (single dose) and rabbits (daily administration for 10 consecutive days), thus being considered acceptable for vaginal use. The efficacy of these complexes against vaginal transmission of CCR5-tropic SHIV 162P3 was further tested in cynomolgus macaques.…”

Multifunctional and hybrid systems based on calcium-phosphate and hydroxyapatite for preventive and regenerative medicine

“…Nanocevi HAp-a, zbog svoje potvrđene biokompatibilnosti, bioaktivnosti i osteokonduktivnosti obećavajuće su u dijagnostici i terapiji kancera kao magnetni-radioizotopni nosači. Gd 3+ dopirane nanocevi HAp-a (Gd-HAp) [52], se intenzivno ispituju kao potencijalni nosači radioizotopa za tretman rane faze kancera kroz teragnostički pristup, odnosno za dijagnostiku i lečenje tumora magnetno-rezonantnim imidžingom i tomografijom.…”