Synthesis and characteristics of gel-derived SiO2-CaO-P2O5-SrO-Ag2O-ZnO bioactive glass: Bioactivity, biocompatibility, and antibacterial properties

Azizabadi, Negar; Azar, Parviz Aberoomand; Tehrani, Mohammad Saber; Derakhshi, Pirouz

doi:10.1016/j.jnoncrysol.2020.120568

Cited by 22 publications

(18 citation statements)

References 43 publications

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“…The images showed the good survival of cells when exposed to the glass extract. The obtained cytotoxicity evaluation results are quite similar to the previous study, 20,21 conrming the biocompatibility of Agincorporated glasses.…”

Section: Biocompatibility Evaluationsupporting

confidence: 89%

“…The biocompatibility of synthetic glasses was evaluated according to the ISO10993-5 standard as reported in the previous studies. [19][20][21] Briey, the broblast cells (L-929) were cultured in 96 well plates (10 3 cells per well) under standard culturing conditions. Diluted extract solutions (100 mL) of synthetic glasses at various concentrations (0, 12.5, 25, 50, and 100%) were added to cell plates for 24 hours.…”

Section: Biocompatibility Testmentioning

confidence: 99%

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Characteristics of Ag-incorporated bioactive glasses prepared by a modified sol–gel method with a shortened synthesis time and without the use of catalysts

et al. 2022

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Section: Biocompatibility Evaluationsupporting

confidence: 89%

Section: Biocompatibility Testmentioning

confidence: 99%

Characteristics of Ag-incorporated bioactive glasses prepared by a modified sol–gel method with a shortened synthesis time and without the use of catalysts

et al. 2022

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“…In fact, bioactive glass is said to produce higher quantity and quality of bone when compared with synthetic HA [ 167 ] and newer hybrid materials have tailorable degradation, which is attractive [ 168 ]. Bioactive glasses have become a focus of investigations for drug delivery within the last one to two decades [ 166 , 169 , 170 ] because of their strong regenerative qualities, reported biocompatibility [ 171 ], and the initial experimental use of bioactive glasses in the treatment of chronic osteomyelitis [ 172 ]. Hasan et al [ 167 ] created a biodegradable, bioactive glass-based antibiotic-releasing putty designed to be press-fitted into bone defects to provide support for bone growth while delivering antimicrobials (vancomycin) for 4–6 weeks to combat bacterial osteomyelitis.…”

Section: Local Drug Delivery Devices For Bacterial Osteomyelitismentioning

confidence: 99%

“…These results, along with the advantageous bioactive properties of bioactive glasses, leave them as an interesting multifunctional device for treatment of bacterial osteomyelitis. The current challenges lie within the optimal composition and fabrication process of bioactive glasses [ 171 ]. However, with a scalable process, it is likely that these materials will be further investigated for drug delivery in the treatment of bacterial osteomyelitis.…”

Section: Local Drug Delivery Devices For Bacterial Osteomyelitismentioning

confidence: 99%

Role of Implantable Drug Delivery Devices with Dual Platform Capabilities in the Prevention and Treatment of Bacterial Osteomyelitis

Billings

Anderson

2022

Bioengineering

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As medicine advances and physicians are able to provide patients with innovative solutions, including placement of temporary or permanent medical devices that drastically improve quality of life of the patient, there is the persistent, recurring problem of chronic bacterial infection, including osteomyelitis. Osteomyelitis can manifest as a result of traumatic or contaminated wounds or implant-associated infections. This bacterial infection can persist as a result of inadequate treatment regimens or the presence of biofilm on implanted medical devices. One strategy to mitigate these concerns is the use of implantable medical devices that simultaneously act as local drug delivery devices (DDDs). This classification of device has the potential to prevent or aid in clearing chronic bacterial infection by delivering effective doses of antibiotics to the area of interest and can be engineered to simultaneously aid in tissue regeneration. This review will provide a background on bacterial infection and current therapies as well as current and prospective implantable DDDs, with a particular emphasis on local DDDs to combat bacterial osteomyelitis.

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“…These particles, bioactive glasses, stand out. They are characterized by their ability to interact with body tissues/fluids and induce ion release [ 16 ], the formation of calcium and phosphate-based precipitates (bioactivity) [ 17 ], hard tissue remineralization [ 7 ], in addition to showing antibacterial activity [ 18 ]. Different compositions of these materials have been reported [ 19 ],such as niobium-based bioactive phosphate glasses [ 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Apical Sealing and Bioactivity of an Experimental Gutta-Percha Containing Niobium Phosphate Bioglass

et al. 2023

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This study evaluated the apical sealing ability and bioactivity of an experimental gutta-percha containing niobium phosphate bioglass. Thirty-six human premolars were endodontically prepared and divided into three groups: GPC—filling with conventional gutta-percha; GBC—filling with bioceramic gutta-percha (EndoSequence BC); GNB—filling with experimental gutta-percha containing niobophosphate. Teeth were stored in tubes containing 2 mL of simulated body fluid (SBF) solution in an oven for 30 days. Then, the samples were immersed in lanthanum nitrate solution and analyzed for apical nanoleakage (NI) with a scanning electron microscope (SEM/EDS) and transmission electron microscope (TEM). Gutta-percha specimens were immersed for 28 days (SBF) and analyzed in SEM/EDS and X-ray diffraction (XRD) to assess bioactivity. NI data originated from the SEM/EDS were analyzed using the Kruskal–Wallis test (α = 5%). NI data originated from TEM and bioactivity were descriptively reported. Statistical analysis did not detect a significant difference between groups (p = 0.13) for NI. In the bioactivity analysis, an abundant layer of hydroxyapatite was identified only in the surface of the GNB group samples. The gutta-percha containing niobophosphate bioglass promoted an apical sealing similar to EndoSequence BC, in addition to demonstrating bioactivity through the deposition of hydroxyapatite on the surface of the material after immersion in SBF.

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Synthesis and characteristics of gel-derived SiO2-CaO-P2O5-SrO-Ag2O-ZnO bioactive glass: Bioactivity, biocompatibility, and antibacterial properties

Cited by 22 publications

References 43 publications

Characteristics of Ag-incorporated bioactive glasses prepared by a modified sol–gel method with a shortened synthesis time and without the use of catalysts

Characteristics of Ag-incorporated bioactive glasses prepared by a modified sol–gel method with a shortened synthesis time and without the use of catalysts

Role of Implantable Drug Delivery Devices with Dual Platform Capabilities in the Prevention and Treatment of Bacterial Osteomyelitis

Apical Sealing and Bioactivity of an Experimental Gutta-Percha Containing Niobium Phosphate Bioglass

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